Orchestra BioMed Holdings, Inc. (OBIO) Ownership
OBIO ownership summary
as of October 17, 2026- Institutions
- 47.8% of shares outstanding
- Insiders
- 24.42% of shares outstanding
- Shares outstanding
- 60.1M
- Float
- 33.0M shares available to trade
- Short interest
- 6.88% 2.5M shares short
- Days to cover
- 7.00 short interest up 7.4% vs prior month
- Institutions 47.77%
- Insiders 24.42%
- Other investors 27.81%
OBIO top institutional holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LLC | 15.90% | 9.6M | $52.1M | +1.2M (+15.0%) | June 30, 2026 |
| 2 | Perceptive Advisors LLC | 8.38% | 5.0M | $27.5M | — | June 30, 2026 |
| 3 | BlackRock Inc | 4.18% | 2.5M | $13.7M | +1.9M (+294.9%) | June 30, 2026 |
| 4 | Vanguard Capital Management, LLC | 3.37% | 2.0M | $11.0M | −181,403 (−8.2%) | June 30, 2026 |
| 5 | Geode Capital Management, LLC | 1.68% | 1.0M | $5.5M | +522,416 (+107.6%) | June 30, 2026 |
| 6 | Alyeska Investment Group, L.P. | 1.66% | 1.0M | $5.5M | — | June 30, 2026 |
| 7 | Propel Bio Management LLC | 1.49% | 897K | $4.9M | — | June 30, 2026 |
| 8 | UBS Asset Mgmt Americas Inc | 1.07% | 642K | $3.5M | +642,154 (0.0%) | June 30, 2026 |
| 9 | State Street Corp | 0.86% | 516K | $2.8M | +346,640 (+204.6%) | June 30, 2026 |
| 10 | Rice Hall James & Associates, LLC | 0.71% | 424K | $2.3M | +404,999 (+2,131.5%) | June 30, 2026 |
| 11 | Charles Schwab Investment Management Inc | 0.58% | 350K | $1.9M | +84,045 (+31.7%) | June 30, 2026 |
| 12 | Northern Trust Corp | 0.57% | 344K | $1.9M | +225,366 (+190.5%) | June 30, 2026 |
| 13 | UBS Group AG | 0.54% | 326K | $1.8M | +275,463 (+547.5%) | June 30, 2026 |
| 14 | Vanguard Fiduciary Trust Co | 0.49% | 292K | $1.6M | +57,039 (+24.2%) | June 30, 2026 |
| 15 | Vanguard Portfolio Management, LLC | 0.46% | 275K | $1.5M | +274,973 (0.0%) | June 30, 2026 |
| 16 | Knott David M Jr | 0.42% | 254K | $1.4M | — | June 30, 2026 |
| 17 | Flat Footed LLC | 0.42% | 251K | $1.4M | +251,372 (0.0%) | June 30, 2026 |
| 18 | Simplify Asset Management Inc. | 0.36% | 219K | $1.2M | — | June 30, 2026 |
| 19 | 683 Capital Management LLC | 0.31% | 185K | $1.0M | −19,076 (−9.3%) | March 31, 2026 |
| 20 | The Goldman Sachs Group Inc | 0.30% | 180K | $978,853 | +24,364 (+15.7%) | June 30, 2026 |
Value at the latest close. Change = shares bought or sold in the latest quarterly filing (13F). In the top 20, 13 holders added 6.2M shares and 2 cut 200K.
OBIO top mutual fund and ETF holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | Vanguard MStar Total Stk Mkt Idx Invest | 2.45% | 1.5M | $8.0M | — | August 31, 2026 |
| 2 | iShares Russell 2000 ETF | 1.64% | 986K | $5.4M | −11,392 (−1.1%) | September 30, 2026 |
| 3 | Fidelity Small Cap Index | 0.71% | 429K | $2.3M | −528 (−0.1%) | July 31, 2026 |
| 4 | iShares Russell 2000 Growth ETF | 0.63% | 378K | $2.1M | −478 (−0.1%) | September 30, 2026 |
| 5 | UBS(Lux)EF Sust Hlth Trnsfm $ P | 0.57% | 344K | $1.9M | +68,749 (+24.9%) | June 30, 2026 |
| 6 | UBS (Lux) EF Biotech (USD) P-acc | 0.50% | 298K | $1.6M | +297,737 (0.0%) | June 30, 2026 |
| 7 | Schwab US Small-Cap ETF™ | 0.38% | 231K | $1.3M | +153 (+0.1%) | September 30, 2026 |
| 8 | Vanguard Russell 2000 ETF | 0.38% | 230K | $1.3M | +6,461 (+2.9%) | August 31, 2026 |
| 9 | Simplify Propel Opportunities ETF | 0.36% | 219K | $1.2M | — | September 30, 2026 |
| 10 | BlackRock Health Sciences Opps Inv A | 0.34% | 206K | $1.1M | — | August 31, 2026 |
| 11 | Fidelity Extended Market Index | 0.22% | 135K | $734,764 | −725 (−0.5%) | August 31, 2026 |
| 12 | iShares Micro-Cap ETF | 0.21% | 126K | $684,340 | −866 (−0.7%) | September 30, 2026 |
| 13 | Schwab Small Cap Index | 0.16% | 97K | $530,034 | — | August 31, 2026 |
| 14 | iShares Russell 2000 Small-Cap Idx Instl | 0.12% | 75K | $406,030 | — | August 31, 2026 |
| 15 | Fidelity Total Market Index | 0.12% | 73K | $397,310 | +120 (+0.2%) | August 31, 2026 |
| 16 | EA Bridgeway Ultra-Small Company Mkt ETF | 0.12% | 73K | $395,212 | — | September 30, 2026 |
| 17 | Goldman Sachs ActiveBeta® US SmCp Eq ETF | 0.12% | 71K | $384,307 | — | September 30, 2026 |
| 18 | Fidelity Series Total Market Index | 0.11% | 65K | $352,413 | +5,641 (+9.6%) | August 31, 2026 |
| 19 | iShares Nasdaq US Biotech ETF USD Acc | 0.09% | 55K | $299,690 | +472 (+0.9%) | September 30, 2026 |
| 20 | Nuveen Small Cap Blend Idx R6 | 0.09% | 52K | $284,043 | — | August 31, 2026 |
Funds report holdings monthly or quarterly; dates differ by fund.
OBIO insider transactions
latest 9| Date | Name | Transaction | Price | Shares | Value |
|---|---|---|---|---|---|
| 2026-03-13 | David P Hochman | Buy | $4.29 | 10,000 | $42,900 |
| 2025-11-14 | David P Hochman | Buy | $4.07 | 5,000 | $20,350 |
| 2025-09-19 | Jason Aryeh | Buy | $2.45 | 1,000 | $2,450 |
| 2025-08-25 | Andrew Lawrence Taylor | Buy | $2.55 | 2,000 | $5,100 |
| 2025-08-25 | Darren Sherman | Buy | $2.62 | 3,000 | $7,860 |
| 2025-08-25 | Eric S Fain | Buy | $2.61 | 5,760 | $15,034 |
| 2025-08-21 | David P Hochman | Buy | $2.49 | 6,000 | $14,940 |
| 2025-08-04 | David P Hochman | Buy | $2.75 | 20,000 | $55,000 |
| 2025-06-26 | Eric S Fain | Sell | $3.05 | 2,683 | $8,183 |
Reported trades by company officers, directors and other filers (including disclosures by members of Congress where EODHD lists them). "—" where the filing gives no share count.
OBIO shares outstanding
Year-end shares outstanding, adjusted for splits.
Who owns OBIO
Institutional investors own 47.8% of Orchestra BioMed's shares and insiders 24.42%. The largest holder is RTW INVESTMENTS, LLC with 15.90% of the shares (9.6M), as of June 30, 2026. Among the top 20 institutions, 13 added shares and 2 reduced their stake in the latest filings. Short interest is 6.88% of the float, or 7.00 days of average trading volume. The share count rose 144.3% since 2020.
Related: OBIO analyst forecast, OBIO key metrics. See the OBIO stock overview for the latest quote and news.
OBIO ownership FAQ
Who owns the most Orchestra BioMed stock?
The largest shareholders of Orchestra BioMed are RTW INVESTMENTS, LLC (15.90%), Perceptive Advisors LLC (8.38%), BlackRock Inc (4.18%), Vanguard Capital Management, LLC (3.37%), Geode Capital Management, LLC (1.68%).
What percentage of Orchestra BioMed is owned by institutions?
Institutions hold 47.8% of Orchestra BioMed's shares outstanding; insiders hold 24.42%.
Which funds own Orchestra BioMed?
The largest fund holders of Orchestra BioMed are Vanguard MStar Total Stk Mkt Idx Invest (2.45%), iShares Russell 2000 ETF (1.64%), Fidelity Small Cap Index (0.71%), iShares Russell 2000 Growth ETF (0.63%), UBS(Lux)EF Sust Hlth Trnsfm $ P (0.57%).
What is Orchestra BioMed's short interest?
2.5M shares of Orchestra BioMed were sold short, 6.88% of the float; at the average daily volume it would take 7.00 days to cover.
Are insiders buying or selling Orchestra BioMed?
Of the latest 9 reported insider transactions in Orchestra BioMed (since June 26, 2025), 8 were purchases and 1 were sales.
How many shares of Orchestra BioMed are outstanding?
Orchestra BioMed has 60.1M shares outstanding, of which 33.0M are in the public float.