Orchestra BioMed Holdings, Inc. (OBIO) Key Metrics

NASDAQ: OBIOValuation, returns, debt and efficiency ratios over 6 years.

OBIO valuation today

Trailing 12 months · as of October 17, 2026
Market cap
$327.6M
Enterprise value
$282.1M
P/E (TTM)
—
Forward P/E
—
PEG ratio
—
Price / sales
10.2
10-yr median 55.8
Price / book
18.4
10-yr median 4.5
EV / EBITDA
—
Dividend yield
—
Beta
0.52

OBIO key metrics, 2020–2025

Fiscal year ended December 31, 2025 · U.S. dollars

OBIO valuation Price multiples at each fiscal year-end price.

Price / sales−89.4%
5.9
2025 · hover or tap a bar for each year
2020: 45.92022: 72.02023: 109.9 (+52.7%)2024: 55.8 (−49.2%)2025: 5.9 (−89.4%)
20202025
Price / book−30.0%
3.1
2025 · hover or tap a bar for each year
2022: 4.82023: 4.5 (−7.9%)2024: 4.5 (+0.2%)2025: 3.1 (−30.0%)
20202025
Free cash flow yield+9.6 pts
−25.0%
2025 · hover or tap a bar for each year
2020: −10.2%2021: −9.6% (+0.6 pts)2022: −11.8% (−2.2 pts)2023: −15.2% (−3.5 pts)2024: −34.5% (−19.3 pts)2025: −25.0% (+9.6 pts)
20202025

OBIO valuation history

Fiscal year-endToday6-year median

OBIO returns on capital

ROEROICROA

Net income (ROE, ROA) or after-tax operating income (ROIC) divided by the average of the opening and closing balance.

OBIO debt vs cash

Total debtCash & short-term investments

Debt includes short- and long-term borrowings and, where reported, lease liabilities.

OBIO cash returned to shareholders

DividendsBuybacksFree cash flow

OBIO price vs earnings per share

Share price at year-endEPS (right axis)

OBIO key metrics

2020–2025
Orchestra BioMed Holdings, Inc. key metrics by fiscal year
202520242023202220212020
Valuation
Market capitalization$198.2M$147.3M$303.3M$254.2M$206.1M$262.0M
Enterprise value$107.6M$97.0M$217.4M$182.3M$200.9M$235.6M
Price / sales5.955.8109.972.0—45.9
Price / book3.14.54.54.8——
EV / sales3.236.878.851.6—41.3
Earnings yield−26.6%−41.4%−16.2%−13.2%−11.2%−8.2%
Free cash flow yield−25.0%−34.5%−15.2%−11.8%−9.6%−10.2%
Shareholder yield (dividends + buybacks)———36.4%——
Share price at fiscal year-end$4.15$4.00$9.13$9.98$10.08$12.81
Per share
Revenue per share$0.70$0.07$0.08$0.14$0.00$0.28
Earnings per share−$1.10−$1.66−$1.48−$1.32−$1.13−$1.04
Operating cash flow per share−$1.03−$1.37−$1.39−$1.15−$0.95−$1.28
Free cash flow per share−$1.04−$1.38−$1.39−$1.17−$0.96−$1.31
Cash per share$2.23$1.81$2.64$3.29$0.53$1.75
Book value per share$1.33$0.90$2.05$2.06−$3.48−$2.37
Tangible book value per share$1.33$0.90$2.05$2.06−$3.48−$2.37
Capex per share$0.01$0.01$0.00$0.02$0.01$0.03
Debt per share$0.33$0.45$0.05$0.47$0.28$0.46
Shares outstanding47.7M36.8M33.2M25.5M20.4M20.4M
Change in shares outstanding+29.7%+10.8%+30.4%+24.6%0.0%—
Returns & profitability
Return on equity (ROE)−109.4%−120.8%−81.5%———
Return on assets (ROA)−55.2%−71.2%−51.5%−61.6%−89.2%−56.1%
Return on tangible assets−45.9%−80.1%−51.6%−35.2%−170.1%−56.1%
Free cash flow margin−147.7%——−845.7%—−468.6%
Financial health
Total debt$16.0M$16.5M$1.7M$11.9M$5.7M$9.5M
Cash & short-term investments$106.5M$66.8M$87.6M$83.8M$10.9M$35.8M
Net debt−$90.6M−$50.3M−$85.9M−$71.9M−$5.2M−$26.3M
Debt / equity0.250.500.020.23——
Debt / assets0.140.220.020.120.420.25
Current ratio6.454.277.954.560.922.52
Quick ratio6.434.267.944.550.922.52
Interest coverage-45.1———-23.5—
Working capital$91.2M$53.0M$77.9M$66.1M−$921,000$21.9M
Invested capital−$27.2M−$17.3M−$17.9M−$19.4M−$76.5M−$74.9M
Tangible asset value$63.4M$33.0M$68.0M$52.5M−$71.2M−$48.5M
Net current asset value$56.4M$26.0M$61.9M$41.7M−$73.4M−$50.4M
Graham net-net per share$1.16$0.65$1.82$1.61−$3.61−$2.48
Capital allocation
Share buybacks (net)———$92.6M——
Capex / revenue1.5%11.0%2.8%16.7%—9.5%
Capex / depreciation1.500.940.272.661.513.93
Stock-based compensation / revenue35.8%402.4%276.3%96.6%—3.9%
R&D / revenue173.8%1,622.6%1,225.4%621.1%—236.3%
SG&A / revenue80.4%907.2%734.0%397.2%—190.0%
Efficiency
Days sales outstanding1.013.212.911.2—10.8
Days of inventory on hand463.9285.4414.1195.0125.6173.7
Days payables outstanding10,785.87,187.36,738.83,398.93,487.74,465.6
Cash conversion cycle (days)-10,320.8-6,888.7-6,311.8-3,192.7—-4,281.1
Receivables turnover358.1027.6228.3132.560.0033.95
Payables turnover0.030.050.050.110.100.08
Inventory turnover0.791.280.881.872.912.10
Asset turnover0.350.030.030.060.000.15
Average receivables$93,500$95,500$97,500$108,500$144,500$168,000
Average payables$5.6M$4.0M$3.4M$3.0M$1.9M$1.8M
Average inventory$241,500$159,500$211,000$172,000$68,500$69,000
Intangibles / total assets0.0%0.0%0.0%0.0%0.0%0.0%

Computed from OBIO's annual financial statements (latest annual report filed March 12, 2026) and the closing share price on each fiscal year-end, adjusted for stock splits. Figures in U.S. dollars; data from EODHD. Averages use the opening and closing balance of each year.

OBIO valuation and financial ratios

Orchestra BioMed earned a return on equity of −109.4% in fiscal 2025. It ended the year with $16.0 million of debt and $106.5 million in cash and short-term investments, a net cash position of $90.6 million. The share count rose 133.5% from 20.4M to 47.7M over 5 years.

See the OBIO income statement, the OBIO chart for price history, or the OBIO stock overview for the latest quote and news.

OBIO key metrics FAQ

What is Orchestra BioMed's return on equity?

Orchestra BioMed's return on equity (ROE) was −109.4% in fiscal 2025: net income of -$52.7 million on average shareholders' equity of $48.2 million.

How much debt does Orchestra BioMed have?

Orchestra BioMed had total debt of $16.0 million at the end of fiscal 2025, a debt-to-equity ratio of 0.25 and more cash than debt.

What is Orchestra BioMed's free cash flow yield?

Orchestra BioMed generated -$49.5 million of free cash flow in fiscal 2025, a free cash flow yield of −25.0% on its market value at year-end ($198.2 million).

What is Orchestra BioMed's current ratio?

Orchestra BioMed's current ratio was 6.45 at the end of fiscal 2025: current assets were 6.45 times current liabilities.

Biotechnology key metrics