Vertex Pharmaceuticals Incorporated (VRTX) Key Metrics
VRTX valuation today
Trailing 12 months · as of October 18, 2026- Market cap
- $126.66B
- Enterprise value
- $125.00B
- P/E (TTM)
- 28.9 10-yr median 26.8
- Forward P/E
- 24.1
- PEG ratio
- 1.90
- Price / sales
- 10.1 10-yr median 10.3
- Price / book
- 6.5 10-yr median 6.7
- EV / EBITDA
- 24.5 10-yr median 29.0
- Dividend yield
- —
- Beta
- 0.28
VRTX key metrics, 2016–2025
Fiscal year ended December 31, 2025 · U.S. dollarsVRTX valuation Price multiples at each fiscal year-end price.
VRTX returns How much profit the business earns on the capital it uses.
VRTX per-share figures Results divided by the shares outstanding at year-end.
VRTX financial health Debt, liquidity and how easily interest is covered.
VRTX efficiency & capital use Working capital cycle and where the cash goes.
VRTX valuation history
VRTX returns on capital
Net income (ROE, ROA) or after-tax operating income (ROIC) divided by the average of the opening and closing balance.
VRTX debt vs cash
Debt includes short- and long-term borrowings and, where reported, lease liabilities.
VRTX cash returned to shareholders
VRTX price vs earnings per share
VRTX key metrics
2016–2025| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Valuation | ||||||||||
| Market capitalization | $116.97B | $103.86B | $105.99B | $74.82B | $57.07B | $62.25B | $57.07B | $42.95B | $37.95B | $18.03B |
| Enterprise value | $114.24B | $99.49B | $95.58B | $64.94B | $50.52B | $56.52B | $53.93B | $40.37B | $36.47B | $17.43B |
| P/E ratio | 29.6 | — | 29.3 | 22.5 | 24.4 | 23.0 | 48.5 | 20.5 | 144.0 | — |
| Price / sales | 9.7 | 9.4 | 10.7 | 8.4 | 7.5 | 10.0 | 13.7 | 14.1 | 15.2 | 10.6 |
| Price / book | 6.3 | 6.3 | 6.0 | 5.4 | 5.7 | 7.2 | 9.4 | 9.7 | 18.6 | 13.5 |
| Price / free cash flow | 36.6 | — | 32.3 | 19.1 | 23.7 | 20.8 | 38.2 | 36.6 | 64.8 | 100.4 |
| Price / operating cash flow | 32.2 | — | 30.0 | 18.1 | 21.6 | 19.1 | 36.4 | 33.8 | 44.9 | 76.3 |
| EV / sales | 9.5 | 9.0 | 9.7 | 7.3 | 6.7 | 9.1 | 13.0 | 13.2 | 14.7 | 10.2 |
| EV / EBITDA | 23.5 | 204.6 | 20.8 | 14.6 | 17.3 | 17.2 | 34.6 | 57.1 | 353.2 | 231.0 |
| EV / free cash flow | 35.8 | — | 29.2 | 16.5 | 21.0 | 18.9 | 36.1 | 34.4 | 62.3 | 97.1 |
| Earnings yield | 3.4% | −0.5% | 3.4% | 4.4% | 4.1% | 4.4% | 2.1% | 4.9% | 0.7% | −0.6% |
| Free cash flow yield | 2.7% | −0.8% | 3.1% | 5.2% | 4.2% | 4.8% | 2.6% | 2.7% | 1.5% | 1.0% |
| Dividend yield | — | — | — | — | 0.2% | 0.4% | 0.0% | 0.0% | 0.0% | 0.0% |
| Shareholder yield (dividends + buybacks) | 1.7% | 1.1% | 0.4% | 0.2% | 2.9% | 1.6% | 0.4% | 0.9% | 0.0% | 0.0% |
| Share price at fiscal year-end | $453.36 | $402.70 | $406.89 | $288.78 | $219.60 | $236.34 | $218.95 | $165.71 | $149.86 | $73.67 |
| Per share | ||||||||||
| Revenue per share | $46.80 | $42.73 | $37.89 | $34.47 | $29.14 | $23.56 | $15.97 | $11.76 | $9.83 | $6.96 |
| Earnings per share | $15.32 | −$2.08 | $13.89 | $12.82 | $9.01 | $10.30 | $4.51 | $8.09 | $1.04 | −$0.46 |
| Operating cash flow per share | $14.08 | −$1.91 | $13.58 | $15.94 | $10.17 | $12.35 | $6.02 | $4.90 | $3.34 | $0.96 |
| Free cash flow per share | $12.38 | −$3.06 | $12.59 | $15.15 | $9.27 | $11.37 | $5.73 | $4.53 | $2.31 | $0.73 |
| Cash per share | $25.62 | $23.71 | $43.06 | $41.60 | $28.95 | $25.28 | $14.61 | $12.22 | $8.25 | $5.86 |
| Book value per share | $72.35 | $63.63 | $67.49 | $53.70 | $38.86 | $32.98 | $23.34 | $17.11 | $8.07 | $5.47 |
| Tangible book value per share | $66.49 | $56.21 | $60.09 | $47.17 | $33.47 | $27.66 | $17.97 | $16.72 | $7.75 | $4.10 |
| Dividends per share | — | — | — | — | $0.39 | $1.01 | $0.04 | $0.08 | $0.00 | $0.00 |
| Capex per share | $1.70 | $1.15 | $0.99 | $0.79 | $0.90 | $0.99 | $0.29 | $0.37 | $1.02 | $0.23 |
| Debt per share | $15.05 | $6.78 | $3.10 | $3.47 | $3.72 | $3.54 | $2.54 | $2.28 | $2.39 | $3.44 |
| Shares outstanding | 258.0M | 257.9M | 260.5M | 259.1M | 259.9M | 263.4M | 260.7M | 259.2M | 253.2M | 244.7M |
| Change in shares outstanding | +0.0% | −1.0% | +0.5% | −0.3% | −1.3% | +1.0% | +0.6% | +2.4% | +3.5% | +1.4% |
| Returns & profitability | ||||||||||
| Return on equity (ROE) | 22.5% | −3.2% | 23.0% | 27.7% | 24.9% | 36.7% | 22.4% | 64.7% | 15.6% | −9.2% |
| Return on invested capital (ROIC) | 29.0% | −1.2% | 56.5% | 89.2% | 73.4% | 84.3% | 42.1% | 52.5% | 14.9% | 1.0% |
| Return on assets (ROA) | 16.2% | −2.4% | 17.7% | 21.0% | 18.6% | 27.0% | 16.2% | 42.8% | 8.2% | −4.2% |
| Return on tangible assets | 16.0% | −2.6% | 17.4% | 20.2% | 19.5% | 26.2% | 17.0% | 34.1% | 7.6% | −4.4% |
| Free cash flow margin | 26.5% | −7.2% | 33.2% | 44.0% | 31.8% | 48.2% | 35.9% | 38.5% | 23.5% | 10.5% |
| Income quality (OCF / net income) | 0.92 | — | 0.98 | 1.24 | 1.13 | 1.20 | 1.33 | 0.61 | 3.21 | — |
| Financial health | ||||||||||
| Total debt | $3.88B | $1.75B | $808.4M | $899.7M | $967.4M | $931.9M | $661.7M | $591.4M | $606.4M | $840.8M |
| Cash & short-term investments | $6.61B | $6.12B | $11.22B | $10.78B | $7.52B | $6.66B | $3.81B | $3.17B | $2.09B | $1.43B |
| Net debt | −$2.73B | −$4.37B | −$10.41B | −$9.88B | −$6.56B | −$5.73B | −$3.15B | −$2.58B | −$1.48B | −$593.8M |
| Debt / equity | 0.21 | 0.11 | 0.05 | 0.06 | 0.10 | 0.11 | 0.11 | 0.13 | 0.30 | 0.63 |
| Debt / assets | 0.15 | 0.08 | 0.04 | 0.05 | 0.07 | 0.08 | 0.08 | 0.09 | 0.17 | 0.29 |
| Net debt / EBITDA | −0.56 | −8.98 | −2.26 | −2.23 | −2.25 | −1.74 | −2.02 | −3.65 | −14.35 | −7.87 |
| Current ratio | 2.90 | 2.69 | 3.99 | 4.83 | 4.46 | 4.33 | 3.61 | 5.17 | 3.08 | 221.40 |
| Quick ratio | 2.46 | 2.35 | 3.78 | 4.66 | 4.30 | 4.18 | 3.49 | 5.00 | 2.94 | 211.64 |
| Interest coverage | 357.9 | -7.6 | 86.9 | 78.6 | 45.2 | 49.1 | 20.5 | 18.6 | 1.8 | 0.1 |
| Working capital | $7.34B | $6.03B | $10.60B | $10.49B | $7.42B | $6.26B | $3.49B | $2.99B | $1.68B | $1.75B |
| Invested capital | $15.94B | $12.04B | $7.17B | $4.03B | $3.54B | $2.96B | $2.94B | $1.86B | $560.1M | $744.4M |
| Tangible asset value | $17.15B | $14.50B | $15.65B | $12.22B | $8.70B | $7.28B | $4.68B | $4.33B | $1.96B | $1.00B |
| Net current asset value | $3.72B | $3.47B | $8.99B | $9.00B | $6.23B | $5.07B | $2.59B | $1.89B | $979.6M | $205.4M |
| Graham number | $157.93 | — | $145.25 | $124.46 | $88.77 | $87.40 | $48.70 | $55.81 | $13.74 | — |
| Graham net-net per share | $5.88 | $6.99 | $29.21 | $30.31 | $20.09 | $16.70 | $8.19 | $6.66 | $3.36 | $0.28 |
| Capital allocation | ||||||||||
| Dividends paid | — | — | — | — | $102.0M | $264.9M | $10.0M | $20.8M | $0 | $0 |
| Share buybacks (net) | $2.02B | $1.18B | $427.6M | $172.0M | $1.56B | $739.4M | $192.0M | $350.0M | $0 | $0 |
| Dividend payout ratio | — | — | — | — | 4.4% | 9.8% | 0.9% | 1.0% | 0.0% | — |
| Dividends + buybacks / free cash flow | 63.2% | — | 13.0% | 4.4% | 69.1% | 33.5% | 13.5% | 31.6% | 0.0% | 0.0% |
| Capex / revenue | 3.6% | 2.7% | 2.6% | 2.3% | 3.1% | 4.2% | 1.8% | 3.1% | 10.4% | 3.3% |
| Capex / operating cash flow | 12.1% | — | 7.3% | 5.0% | 8.9% | 8.0% | 4.8% | 7.5% | 30.7% | 24.0% |
| Capex / depreciation | 2.09 | 1.44 | 1.43 | 1.38 | 1.87 | 2.37 | 0.71 | 1.32 | 4.23 | 0.92 |
| Stock-based compensation / revenue | 5.7% | 6.3% | 5.9% | 5.5% | 5.8% | 6.9% | 8.7% | 10.7% | 11.7% | 14.0% |
| R&D / revenue | 31.1% | 32.9% | 32.0% | 29.7% | 40.3% | 29.5% | 42.1% | 46.5% | 53.2% | 61.6% |
| SG&A / revenue | 14.5% | 13.3% | 11.5% | 9.9% | 11.1% | 12.4% | 15.8% | 18.3% | 19.9% | 25.4% |
| Efficiency | ||||||||||
| Days sales outstanding | 55.4 | 52.5 | 55.6 | 52.7 | 48.7 | 44.7 | 45.7 | 41.4 | 35.4 | 40.6 |
| Days of inventory on hand | 292.1 | 231.8 | 173.4 | 137.5 | 127.9 | 111.1 | 97.2 | 105.3 | 125.7 | 115.9 |
| Days payables outstanding | 88.3 | 92.8 | 96.7 | 84.3 | 70.7 | 60.2 | 66.2 | 82.4 | 89.8 | 118.3 |
| Cash conversion cycle (days) | 259.1 | 191.6 | 132.3 | 105.9 | 106.0 | 95.6 | 76.8 | 64.2 | 71.2 | 38.3 |
| Receivables turnover | 6.59 | 6.95 | 6.57 | 6.93 | 7.49 | 8.17 | 7.98 | 8.82 | 10.32 | 8.99 |
| Payables turnover | 4.13 | 3.93 | 3.77 | 4.33 | 5.17 | 6.07 | 5.52 | 4.43 | 4.06 | 3.09 |
| Inventory turnover | 1.25 | 1.57 | 2.10 | 2.66 | 2.85 | 3.29 | 3.75 | 3.47 | 2.90 | 3.15 |
| Asset turnover | 0.50 | 0.49 | 0.48 | 0.57 | 0.60 | 0.62 | 0.57 | 0.62 | 0.77 | 0.63 |
| Average receivables | $1.83B | $1.59B | $1.50B | $1.29B | $1.01B | $759.5M | $521.6M | $345.5M | $241.2M | $189.4M |
| Average payables | $437.4M | $388.9M | $334.4M | $249.4M | $175.1M | $121.4M | $99.3M | $92.5M | $67.7M | $68.2M |
| Average inventory | $1.45B | $972.1M | $599.7M | $406.9M | $316.9M | $224.1M | $145.9M | $118.1M | $94.7M | $66.8M |
| Intangibles / total assets | 5.8% | 8.5% | 8.5% | 9.3% | 10.4% | 11.9% | 16.9% | 1.6% | 2.2% | 11.6% |
Computed from VRTX's annual financial statements (latest annual report filed February 13, 2026) and the closing share price on each fiscal year-end, adjusted for stock splits. Figures in U.S. dollars; data from EODHD. Averages use the opening and closing balance of each year.
VRTX valuation and financial ratios
At the end of fiscal 2025 (December 31, 2025), Vertex traded at 29.6 times earnings, against a 10-year median of 26.8. Based on the latest twelve months, the trailing P/E is 28.9 and the forward P/E is 24.1. Vertex earned a return on equity of 22.5% and a return on invested capital of 29.0% in fiscal 2025. It ended the year with $3.9 billion of debt and $6.6 billion in cash and short-term investments, a net cash position of $2.7 billion. It returned $2.0 billion to shareholders: $0 in dividends and $2.0 billion in share buybacks, 63% of free cash flow. The share count rose 5.4% from 244.7M to 258.0M over 9 years.
See the VRTX income statement, the VRTX chart for price history, or the VRTX stock overview for the latest quote and news.
VRTX key metrics FAQ
What is Vertex's P/E ratio?
Vertex's trailing P/E ratio is 28.9 based on the last twelve months of earnings (as of October 18, 2026), and its forward P/E is 24.1. At the end of fiscal 2025 it was 29.6, compared with a 10-year median of 26.8.
What is Vertex's EV/EBITDA?
Vertex's enterprise value was 23.5 times EBITDA at the end of fiscal 2025 (enterprise value $114.2 billion, EBITDA $4.9 billion); the current EV/EBITDA is 24.5.
What is Vertex's return on equity?
Vertex's return on equity (ROE) was 22.5% in fiscal 2025: net income of $4.0 billion on average shareholders' equity of $17.5 billion.
What is Vertex's ROIC?
Vertex's return on invested capital was 29.0% in fiscal 2025, using after-tax operating income divided by average debt plus equity minus cash.
How much debt does Vertex have?
Vertex had total debt of $3.9 billion at the end of fiscal 2025, a debt-to-equity ratio of 0.21 and more cash than debt.
Does Vertex buy back its shares?
Yes. Vertex spent $2.0 billion on net share repurchases in fiscal 2025 Shares outstanding changed +0.0% over the year, to 258.0M..
What is Vertex's free cash flow yield?
Vertex generated $3.2 billion of free cash flow in fiscal 2025, a free cash flow yield of 2.7% on its market value at year-end ($117.0 billion).
What is Vertex's current ratio?
Vertex's current ratio was 2.90 at the end of fiscal 2025: current assets were 2.90 times current liabilities.