Vertex Pharmaceuticals Incorporated (VRTX) Cash Flow Statement
Where VRTX’s cash came from and went, 2025
December 31, 2025 · U.S. dollars- Cash from operations
- $3.63B
- Capital expenditures
- $437.6M 3.6% of revenue
- Free cash flow
- $3.19B 26.5% margin
- Returned to shareholders
- $2.02B 63% of free cash flow
- Change in cash
- $515.6M cash at year-end $5.09B
Cash from operations
$3.63B
Capital expenditures
−$437.6M
Investments (net)
−$483.1M
Acquisitions & other
−$24.7M
Share buybacks (net)
−$2.02B
Other financing
−$238.5M
Currency & other
+$85.5M
Change in cash
$515.6M
Drawn to scale: where the cash came from and how it was used. Hover for values.
VRTX operating cash flow, capex and free cash flow
Operating cash flowCapital expendituresFree cash flowFCF margin (right axis)
VRTX cash flow trends, 2016–2025
| Metric | Trend | Then | Latest | Change |
|---|---|---|---|---|
| Operating cash flow | $236.1M2016 | $3.63B2025 | +35.5%/yr | |
| Capital expenditures | $56.6M2016 | $437.6M2025 | +25.5%/yr | |
| Free cash flow | $179.5M2016 | $3.19B2025 | +37.7%/yr | |
| Free cash flow margin | 10.5%2016 | 26.5%2025 | +15.9 pts | |
| Operating cash flow / net income | 9.222017 | 0.922025 | −8.30 | |
| Stock-based compensation | $237.7M2016 | $685.9M2025 | +12.5%/yr | |
| Dividends paid | $02016 | $102.0M2021 | — | |
| Share buybacks (net) | $02016 | $2.02B2025 | — | |
| Capex / revenue | 3.3%2016 | 3.6%2025 | +0.3 pts |
Change is the average annual growth (CAGR) or the difference between the first and latest year.
VRTX cash flow by activity
OperatingInvestingFinancingChange in cash
VRTX net income vs operating cash flow
Net incomeOperating cash flow
Operating cash flow above net income usually means earnings are backed by cash (depreciation and stock-based pay are non-cash expenses).
VRTX cash flow statement
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Operating activities | ||||||||||
| Net income | $3.95B | −$535.6M | $3.62B | $3.32B | $2.34B | $2.71B | $1.18B | $2.09B | $91.6M | −$84.0M |
| Depreciation & amortization | $209.8M | $207.2M | $181.3M | $148.3M | $125.6M | $109.5M | $106.9M | $72.4M | $61.4M | $61.4M |
| Stock-based compensation | $685.9M | $698.5M | $581.2M | $491.3M | $441.4M | $429.5M | $360.5M | $325.0M | $290.7M | $237.7M |
| Change in working capital | −$1.20B | −$514.8M | −$265.7M | $340.8M | −$105.2M | −$54.5M | −$66.1M | $238.0M | $15.3M | −$2.1M |
| Other non-cash items | −$18.4M | −$347.9M | −$579.1M | −$172.5M | −$160.4M | $57.3M | −$8.8M | −$1.45B | $385.9M | $23.1M |
| Cash from operating activities | $3.63B | −$492.6M | $3.54B | $4.13B | $2.64B | $3.25B | $1.57B | $1.27B | $844.9M | $236.1M |
| Investing activities | ||||||||||
| Capital expenditures | −$437.6M | −$297.7M | −$258.4M | −$204.7M | −$235.0M | −$259.8M | −$75.5M | −$95.5M | −$259.4M | −$56.6M |
| Investments (net) | −$483.1M | −$3.77B | −$2.08B | $227.3M | −$28.9M | $378.5M | $33.7M | −$15.3M | −$163.4M | $120.9M |
| Acquisitions & other investing | −$24.7M | $297.7M | −$803.7M | −$343.7M | −$77.0M | −$19.3M | −$1.19B | −$91.3M | −$14.9M | $40.1M |
| Cash from investing activities | −$945.4M | −$3.77B | −$3.14B | −$321.1M | −$340.9M | $99.4M | −$1.24B | −$202.2M | −$437.7M | $104.5M |
| Financing activities | ||||||||||
| Dividends paid | — | — | — | — | −$102.0M | −$264.9M | −$10.0M | −$20.8M | $0 | $0 |
| Share repurchases & issuance (net) | −$2.02B | −$1.18B | −$427.6M | −$172.0M | −$1.56B | −$739.4M | −$192.0M | −$350.0M | $344.8M | $68.2M |
| Net borrowing (repayment) | −$5.4M | −$33.6M | −$44.9M | −$85.5M | −$24.4M | −$29.0M | −$35.0M | −$7.1M | −$284.1M | −$9.5M |
| Shares issued | $0 | $0 | $0 | $0 | $0 | $0 | $343.2M | $289.3M | $0 | $0 |
| Other financing | −$238.5M | −$284.2M | −$89.7M | $189.8M | $209.7M | $528.1M | $20.6M | $17.5M | $7.7M | $74.6M |
| Cash from financing activities | −$2.26B | −$1.49B | −$562.2M | −$67.7M | −$1.48B | −$505.3M | $126.8M | −$71.2M | $68.4M | $133.3M |
| Summary | ||||||||||
| Net change in cash | $515.6M | −$5.80B | −$139.7M | $3.71B | $811.2M | $2.87B | $462.4M | $990.7M | $481.5M | $469.2M |
| Cash at end of period | $5.09B | $4.57B | $10.37B | $10.51B | $6.80B | $5.99B | $3.12B | $2.66B | $1.67B | $1.18B |
| Free cash flow | $3.19B | −$790.3M | $3.28B | $3.93B | $2.41B | $2.99B | $1.49B | $1.17B | $585.5M | $179.5M |
| Free cash flow margin | 26.5% | −7.2% | 33.2% | 44.0% | 31.8% | 48.2% | 35.9% | 38.5% | 23.5% | 10.5% |
| Capex / revenue | 3.6% | 2.7% | 2.6% | 2.3% | 3.1% | 4.2% | 1.8% | 3.1% | 10.4% | 3.3% |
| Operating cash flow / net income | 0.92 | — | 0.98 | 1.24 | 1.13 | 1.20 | 1.33 | 0.61 | 9.22 | — |
| Jun '26 | Mar '26 | Dec '25 | Sep '25 | Jun '25 | Mar '25 | Dec '24 | Sep '24 | Jun '24 | Mar '24 | Dec '23 | Sep '23 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating activities | ||||||||||||
| Net income | $1.10B | $1.03B | $1.19B | $1.08B | $1.03B | $646.3M | $913.0M | $1.05B | −$3.59B | $1.10B | $968.8M | $1.04B |
| Depreciation & amortization | $56.5M | $55.9M | $55.7M | $54.0M | $51.7M | $48.4M | $46.5M | $53.2M | $54.0M | $53.5M | $59.0M | $42.1M |
| Stock-based compensation | $170.2M | $166.4M | $157.6M | $194.9M | $167.3M | $166.1M | $167.8M | $184.6M | $154.2M | $191.9M | $208.6M | $130.9M |
| Change in working capital | −$115.0M | $244.7M | −$947.8M | $149.6M | −$132.4M | −$268.5M | −$560.2M | $157.5M | −$241.4M | $129.3M | −$838.9M | $188.9M |
| Other non-cash items | −$86.1M | −$70.3M | $41.4M | −$240.0M | −$46.4M | $226.6M | $17.5M | −$70.9M | −$126.8M | −$167.7M | −$162.9M | −$128.8M |
| Cash from operating activities | $1.13B | $1.43B | $498.0M | $1.24B | $1.07B | $818.9M | $584.6M | $1.37B | −$3.75B | $1.31B | $234.6M | $1.27B |
| Investing activities | ||||||||||||
| Capital expenditures | −$112.2M | −$133.4M | −$149.4M | −$101.8M | −$145.7M | −$40.7M | −$92.6M | −$67.7M | −$76.7M | −$248.4M | −$58.1M | −$40.6M |
| Investments (net) | $68.1M | −$298.5M | −$122.8M | −$117.0M | −$484.5M | −$55.8M | −$821.9M | −$348.0M | −$463.7M | −$2.14B | −$886.5M | −$117.7M |
| Acquisitions & other investing | −$1.7M | $0 | −$15.9M | $101.8M | $145.7M | $40.7M | $92.6M | $67.7M | $76.7M | $248.4M | $58.1M | $40.6M |
| Cash from investing activities | −$45.8M | −$431.9M | −$288.1M | −$117.0M | −$484.5M | −$55.8M | −$821.9M | −$348.0M | −$463.7M | −$2.14B | −$886.5M | −$117.7M |
| Financing activities | ||||||||||||
| Dividends paid | — | — | — | — | — | — | — | — | — | — | — | −$15.4M |
| Share repurchases & issuance (net) | −$473.8M | −$565.4M | −$130.9M | −$1.07B | −$391.8M | −$426.1M | −$417.9M | −$307.7M | −$320.3M | −$131.2M | −$149.5M | −$117.0M |
| Net borrowing (repayment) | — | — | −$1.4M | −$1.4M | −$1.3M | −$1.3M | −$1.3M | −$5.4M | — | — | — | — |
| Shares issued | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other financing | $47.1M | $26.6M | $55.1M | −$82.0M | $43.9M | −$253.0M | $27.9M | −$74.4M | −$38.3M | −$226.3M | $29.7M | −$32.6M |
| Cash from financing activities | −$426.7M | −$538.8M | −$77.2M | −$1.15B | −$349.2M | −$680.4M | −$391.3M | −$387.5M | −$358.6M | −$357.5M | −$119.8M | −$165.0M |
| Summary | ||||||||||||
| Net change in cash | $649.2M | $417.1M | $140.0M | −$34.2M | $296.6M | $113.2M | −$675.9M | $657.1M | −$4.58B | −$1.20B | −$744.3M | $963.2M |
| Cash at end of period | $6.15B | $5.50B | $5.09B | $4.95B | $4.98B | $4.69B | $4.57B | $5.25B | $4.58B | $9.17B | $10.37B | $11.12B |
| Free cash flow | $1.01B | $1.29B | $348.6M | $1.14B | $927.4M | $778.2M | $492.0M | $1.30B | −$3.83B | $1.06B | $176.5M | $1.23B |
| Free cash flow margin | 30.4% | 43.3% | 10.8% | 37.0% | 31.3% | 28.1% | 16.9% | 47.0% | −144.8% | 39.4% | 7.0% | 49.4% |
| Capex / revenue | 3.4% | 4.5% | 4.6% | 3.3% | 4.9% | 1.5% | 3.2% | 2.4% | 2.9% | 9.2% | 2.3% | 1.6% |
| Operating cash flow / net income | 1.02 | 1.38 | 0.42 | 1.15 | 1.04 | 1.27 | 0.64 | 1.31 | — | 1.19 | 0.24 | 1.23 |
Negative numbers are cash paid out. Quarterly columns are labeled by the month the quarter ended. Figures in U.S. dollars as reported; data from EODHD.
VRTX cash generation
In fiscal 2025 (ended December 31, 2025), Vertex generated $3.6 billion of cash from operations and spent $437.6 million on capital expenditures, leaving free cash flow of $3.2 billion, 26.5% of revenue. It returned $2.0 billion to shareholders through dividends ($0) and net share buybacks ($2.0 billion). Cash and equivalents rose by $515.6 million over the year.
Related: VRTX income statement, VRTX balance sheet. See the VRTX stock overview for the latest quote and news.
VRTX cash flow FAQ
What is Vertex's free cash flow?
Vertex's free cash flow was $3.2 billion in fiscal 2025: $3.6 billion of operating cash flow minus $437.6 million of capital expenditures It was -$790.3 million a year earlier..
How much cash does Vertex generate from operations?
Vertex generated $3.6 billion of cash from operating activities in fiscal 2025, 0.92 times its net income of $4.0 billion.
How much does Vertex spend on capital expenditures?
Vertex spent $437.6 million on capital expenditures in fiscal 2025, 3.6% of revenue, compared with $297.7 million the year before.
How much stock does Vertex buy back?
Vertex spent $2.0 billion on net share repurchases in fiscal 2025.