Agios Pharmaceuticals, Inc. (AGIO) Ownership

NASDAQ: AGIOTop holders, insider trades and short interest.

AGIO ownership summary

as of October 18, 2026
Institutions
115.5%
of shares outstanding
Insiders
1.07%
of shares outstanding
Shares outstanding
59.7M
Float
50.0M
shares available to trade
Short interest
11.87%
7.0M shares short
Days to cover
7.21
short interest down 7.2% vs prior month
  • Institutions 115.45%
  • Insiders 1.07%

AGIO top institutional holders

20 largest
Agios Pharmaceuticals, Inc. top institutional holders
#Holder% of sharesSharesValueChangeReported
1BlackRock Inc10.81%6.5M$202.2M+701,040 (+12.2%)June 30, 2026
2Farallon Capital Management, L.L.C.9.91%5.9M$185.3M+233,400 (+4.1%)June 30, 2026
3State Street Corp5.92%3.5M$110.7M+168,754 (+5.0%)June 30, 2026
4Lynx1 Capital Management, LP5.71%3.4M$106.8M+797,369 (+30.5%)June 30, 2026
5D. E. Shaw & Co LP5.20%3.1M$97.3M+425,836 (+15.9%)June 30, 2026
6Vanguard Portfolio Management, LLC4.85%2.9M$90.8M+287,162 (+11.0%)June 30, 2026
7Vanguard Capital Management, LLC4.49%2.7M$84.0M+49,529 (+1.9%)June 30, 2026
8Armistice Capital, LLC4.02%2.4M$75.2M−316,000 (−11.6%)June 30, 2026
9Erste Asset Management GmbH3.61%2.2M$67.5M−550,000 (−20.3%)June 30, 2026
10Delaware Management Holdings Inc3.54%2.1M$66.1M+616,374 (+41.2%)June 30, 2026
11Geode Capital Management, LLC2.64%1.6M$49.3M+106,358 (+7.2%)June 30, 2026
12Susquehanna International Group, LLP2.30%1.4M$43.1M+30,605 (+2.3%)June 30, 2026
13ADAR1 Capital Management LLC2.16%1.3M$40.3M+1.1M (+815.6%)June 30, 2026
14BNP Paribas Investment Partners SA2.14%1.3M$40.1M−300,796 (−19.0%)June 30, 2026
15Dimensional Fund Advisors, Inc.2.09%1.2M$39.1M+97,124 (+8.4%)June 30, 2026
16GW&K Investment Management, LLC2.02%1.2M$37.8M−8,286 (−0.7%)June 30, 2026
17The Goldman Sachs Group Inc1.93%1.2M$36.0M+345,156 (+42.8%)June 30, 2026
18UBS Group AG1.65%986K$30.9M+853,291 (+643.8%)June 30, 2026
19Morgan Stanley - Brokerage Accounts1.61%963K$30.2M−4,269 (−0.4%)June 30, 2026
20Nuveen, LLC1.46%874K$27.4M+151,212 (+20.9%)June 30, 2026

Value at the latest close. Change = shares bought or sold in the latest quarterly filing (13F). In the top 20, 15 holders added 6.0M shares and 5 cut 1.2M.

AGIO top mutual fund and ETF holders

20 largest
Agios Pharmaceuticals, Inc. top fund holders
#Holder% of sharesSharesValueChangeReported
1Vanguard MStar Total Stk Mkt Idx Invest3.18%1.9M$59.4M−3,480 (−0.2%)August 31, 2026
2State Street® SPDR® S&P® Biotech ETF2.87%1.7M$53.7M−32,750 (−1.9%)September 30, 2026
3Nomura Small Cap Core I2.84%1.7M$53.1M—August 31, 2026
4iShares Russell 2000 ETF2.56%1.5M$47.9M−17,600 (−1.1%)September 30, 2026
5Vanguard Small Cap Index2.29%1.4M$42.8M+826 (+0.1%)August 31, 2026
6Vanguard MStar Small Cap Growth Indx Inv1.31%783K$24.5M−6,316 (−0.8%)August 31, 2026
7Fidelity Small Cap Index1.08%646K$20.2M+5,515 (+0.9%)July 31, 2026
8BNP Paribas US Small Cap ClassicC1.05%625K$19.6M−1,198 (−0.2%)August 31, 2026
9Strategic Advisers U.S. Total Stock0.90%540K$16.9M+13,439 (+2.6%)August 31, 2026
10iShares Russell 2000 Value ETF0.87%522K$16.3M+790 (+0.2%)September 30, 2026
11iShares Biotechnology ETF0.76%455K$14.2M−3,440 (−0.8%)September 30, 2026
12BNP Paribas Health Cr Innovtr Cl Cap0.75%450K$14.1M−82 (−0.0%)August 31, 2026
13Vanguard Russell 2000 ETF0.57%340K$10.6M+8,116 (+2.4%)August 31, 2026
14Schwab US Small-Cap ETF™0.53%314K$9.8M+207 (+0.1%)September 30, 2026
15Nuveen Quant Small Cap Equity R60.52%308K$9.6M—August 31, 2026
16Fidelity Extended Market Index0.49%293K$9.2M−2,804 (−0.9%)August 31, 2026
17DFA US Small Cap I0.43%258K$8.1M—August 31, 2026
18BlackRock Advantage Small Cap Core Instl0.42%248K$7.8M+32,591 (+15.1%)August 31, 2026
19DFA US Micro Cap I0.41%245K$7.7M—August 31, 2026
20AMG GW&K Small Cap Core N0.38%225K$7.0M+31,962 (+16.6%)August 31, 2026

Funds report holdings monthly or quarterly; dates differ by fund.

AGIO insider transactions

latest 20
Agios Pharmaceuticals, Inc. insider transactions
DateNameTransactionPriceSharesValue
2026-04-02James William BurnsSell$34.713,280$113,849
2026-04-02Sarah GheuensSell$34.712,940$102,047
2026-04-02Tsveta MilanovaSell$34.713,262$113,224
2026-04-02Cecilia JonesSell$34.713,141$109,024
2026-03-05Krishnan ViswanadhanSell$27.802,959$82,260
2026-03-03Gilbert Ray Cisneros, Jr.Buy$28.48——
2026-01-05Tsveta MilanovaSell$27.022,872$77,601
2025-12-30Brian GoffSell$27.0918,703$506,664
2025-12-30Cecilia JonesSell$27.092,932$79,428
2025-12-30James William BurnsSell$27.092,932$79,428
2025-12-30Sarah GheuensSell$27.092,932$79,428
2025-12-30Tsveta MilanovaSell$27.092,932$79,428
2025-12-11Gilbert Ray Cisneros, Jr.Buy$27.46——
2025-11-12David ScaddenSell$43.84200$8,768
2025-10-30Sarah GheuensSell$43.81200$8,762
2025-10-27Sarah GheuensSell$43.923,302$145,024
2025-10-08David ScaddenSell$41.00200$8,200
2025-09-26Cecilia JonesSell$36.773,651$134,247
2025-09-05Theodore James Jr. WashburnSell$36.878,546$315,091
2025-08-08Brian GoffSell$36.6711,085$406,487

Reported trades by company officers, directors and other filers (including disclosures by members of Congress where EODHD lists them). "—" where the filing gives no share count.

AGIO shares outstanding

Shares outstanding

Year-end shares outstanding, adjusted for splits.

Who owns AGIO

Institutional investors own 115.5% of Agios Pharmaceuticals's shares and insiders 1.07%. The largest holder is BlackRock Inc with 10.81% of the shares (6.5M), as of June 30, 2026. Among the top 20 institutions, 15 added shares and 5 reduced their stake in the latest filings. Short interest is 11.87% of the float, or 7.21 days of average trading volume. The share count rose 66.1% since 2014.

Related: AGIO analyst forecast, AGIO key metrics. See the AGIO stock overview for the latest quote and news.

AGIO ownership FAQ

Who owns the most Agios Pharmaceuticals stock?

The largest shareholders of Agios Pharmaceuticals are BlackRock Inc (10.81%), Farallon Capital Management, L.L.C. (9.91%), State Street Corp (5.92%), Lynx1 Capital Management, LP (5.71%), D. E. Shaw & Co LP (5.20%).

What percentage of Agios Pharmaceuticals is owned by institutions?

Institutions hold 115.5% of Agios Pharmaceuticals's shares outstanding; insiders hold 1.07%.

Which funds own Agios Pharmaceuticals?

The largest fund holders of Agios Pharmaceuticals are Vanguard MStar Total Stk Mkt Idx Invest (3.18%), State Street® SPDR® S&P® Biotech ETF (2.87%), Nomura Small Cap Core I (2.84%), iShares Russell 2000 ETF (2.56%), Vanguard Small Cap Index (2.29%).

What is Agios Pharmaceuticals's short interest?

7.0M shares of Agios Pharmaceuticals were sold short, 11.87% of the float; at the average daily volume it would take 7.21 days to cover.

Are insiders buying or selling Agios Pharmaceuticals?

Of the latest 20 reported insider transactions in Agios Pharmaceuticals (since August 8, 2025), 2 were purchases and 18 were sales.

How many shares of Agios Pharmaceuticals are outstanding?

Agios Pharmaceuticals has 59.7M shares outstanding, of which 50.0M are in the public float.

Biotechnology: ownership