Agios Pharmaceuticals, Inc. (AGIO) Key Metrics
AGIO valuation today
Trailing 12 months · as of October 18, 2026- Market cap
- $1.87B
- Enterprise value
- $1.45B
- P/E (TTM)
- —
- Forward P/E
- 2.5
- PEG ratio
- —
- Price / sales
- 19.0 10-yr median 29.2
- Price / book
- 2.0 10-yr median 2.7
- EV / EBITDA
- —
- Dividend yield
- —
- Beta
- 0.63
AGIO key metrics, 2016–2025
Fiscal year ended December 31, 2025 · U.S. dollarsAGIO valuation Price multiples at each fiscal year-end price.
Price / sales−44.0%
29.2
2025 · hover or tap a bar for each year
20162025
Price / book+7.1%
1.3
2025 · hover or tap a bar for each year
20162025
Free cash flow yield−3.3 pts
−23.9%
2025 · hover or tap a bar for each year
20162025
AGIO returns How much profit the business earns on the capital it uses.
Return on equity−87.5 pts
−30.2%
2025 · hover or tap a bar for each year
20162025
Return on invested capital+29.7 pts
−68.9%
2025 · hover or tap a bar for each year
20162025
Return on assets−79.7 pts
−27.9%
2025 · hover or tap a bar for each year
20162025
Free cash flow margin
−698.3%
2025 · hover or tap a bar for each year
20162025
Asset turnover+30.0%
0.04
2025 · hover or tap a bar for each year
20162025
AGIO per-share figures Results divided by the shares outstanding at year-end.
Revenue per share+47.8%
$0.93
2025 · hover or tap a bar for each year
20162025
Earnings per share
−$7.12
2025 · hover or tap a bar for each year
20162025
Free cash flow per share
−$6.51
2025 · hover or tap a bar for each year
20162025
Book value per share−22.7%
$20.58
2025 · hover or tap a bar for each year
20162025
Shares outstanding+0.1%
58.0M
2025 · hover or tap a bar for each year
20162025
AGIO financial health Debt, liquidity and how easily interest is covered.
Debt / equity−8.9%
0.03
2025 · hover or tap a bar for each year
20162025
Net debt+$22.5M
−$814.2M
2025 · hover or tap a bar for each year
20162025
Current ratio−3.7%
11.46
2025 · hover or tap a bar for each year
20162025
Debt / assets−9.5%
0.03
2025 · hover or tap a bar for each year
20162025
AGIO efficiency & capital use Working capital cycle and where the cash goes.
Days sales outstanding+15 days
50 days
2025 · hover or tap a bar for each year
20162025
Days of inventory−1,087 days
959 days
2025 · hover or tap a bar for each year
20162025
Days payables outstanding−603 days
554 days
2025 · hover or tap a bar for each year
20162025
Cash conversion cycle−469 days
454 days
2025 · hover or tap a bar for each year
20162025
Capex / revenue+3.4 pts
8.0%
2025 · hover or tap a bar for each year
20162025
AGIO valuation history
Fiscal year-endToday10-year median
AGIO returns on capital
ROEROICROA
Net income (ROE, ROA) or after-tax operating income (ROIC) divided by the average of the opening and closing balance.
AGIO debt vs cash
Total debtCash & short-term investments
Debt includes short- and long-term borrowings and, where reported, lease liabilities.
AGIO cash returned to shareholders
DividendsBuybacksFree cash flow
AGIO price vs earnings per share
Share price at year-endEPS (right axis)
AGIO key metrics
2016–2025| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Valuation | ||||||||||
| Market capitalization | $1.58B | $1.90B | $1.24B | $1.54B | $1.99B | $2.99B | $2.86B | $2.65B | $2.66B | $1.63B |
| Enterprise value | $763.8M | $1.07B | $534.4M | $841.0M | $1.06B | $2.52B | $2.41B | $1.90B | $2.22B | $1.21B |
| P/E ratio | — | 2.8 | — | — | 1.2 | — | — | — | — | — |
| Price / sales | 29.2 | 52.1 | 46.2 | 108.0 | — | 14.7 | 24.3 | 28.1 | 61.9 | 23.4 |
| Price / book | 1.3 | 1.2 | 1.5 | 1.4 | 1.5 | 7.5 | 4.5 | 3.9 | 7.1 | 4.6 |
| Price / free cash flow | — | — | — | — | — | — | — | — | — | 57.0 |
| Price / operating cash flow | — | — | — | — | — | — | — | — | — | 42.3 |
| EV / sales | 14.1 | 29.2 | 19.9 | 59.1 | — | 12.4 | 20.5 | 20.2 | 51.6 | 17.4 |
| EV / EBITDA | — | 1.5 | — | — | — | — | — | — | — | — |
| EV / free cash flow | — | — | — | — | — | — | — | — | — | 42.4 |
| Earnings yield | −26.2% | 35.4% | −28.4% | −15.1% | 80.8% | −11.0% | −14.4% | −13.1% | −11.8% | −12.2% |
| Free cash flow yield | −23.9% | −20.6% | −24.0% | −20.4% | −20.8% | −10.2% | −13.4% | −11.8% | −10.9% | 1.8% |
| Dividend yield | — | — | — | — | 1.9% | — | — | — | 0.0% | 0.0% |
| Shareholder yield (dividends + buybacks) | — | — | 0.0% | 0.0% | 42.3% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Share price at fiscal year-end | $27.22 | $32.86 | $22.27 | $28.08 | $32.87 | $43.33 | $47.75 | $46.11 | $57.17 | $41.73 |
| Per share | ||||||||||
| Revenue per share | $0.93 | $0.63 | $0.48 | $0.26 | $0.00 | $2.94 | $1.97 | $1.64 | $0.92 | $1.79 |
| Earnings per share | −$7.12 | $11.64 | −$6.33 | −$4.23 | $26.55 | −$4.74 | −$6.86 | −$6.03 | −$6.75 | −$5.07 |
| Operating cash flow per share | −$6.43 | −$6.73 | −$5.32 | −$5.65 | −$6.74 | −$4.21 | −$6.18 | −$5.30 | −$6.12 | $0.99 |
| Free cash flow per share | −$6.51 | −$6.76 | −$5.34 | −$5.74 | −$6.83 | −$4.42 | −$6.38 | −$5.42 | −$6.22 | $0.73 |
| Cash per share | $14.74 | $15.44 | $13.96 | $14.29 | $16.87 | $8.30 | $9.42 | $14.03 | $12.19 | $14.66 |
| Book value per share | $20.58 | $26.62 | $14.57 | $20.09 | $21.37 | $5.79 | $10.68 | $11.97 | $8.06 | $9.16 |
| Tangible book value per share | $20.58 | $26.62 | $14.57 | $20.09 | $21.37 | $5.79 | $10.68 | $11.97 | $8.06 | $9.16 |
| Dividends per share | — | — | — | — | $0.62 | — | — | — | $0.00 | $0.00 |
| Capex per share | $0.07 | $0.03 | $0.02 | $0.09 | $0.09 | $0.20 | $0.20 | $0.12 | $0.10 | $0.25 |
| Debt per share | $0.69 | $0.98 | $1.29 | $1.56 | $1.61 | $1.52 | $1.89 | $1.04 | $2.70 | $3.94 |
| Shares outstanding | 58.0M | 57.9M | 55.7M | 54.8M | 60.4M | 69.0M | 60.0M | 57.4M | 46.6M | 39.1M |
| Change in shares outstanding | +0.1% | +4.0% | +1.6% | −9.4% | −12.4% | +15.0% | +4.5% | +23.2% | +19.1% | +4.5% |
| Returns & profitability | ||||||||||
| Return on equity (ROE) | −30.2% | 57.3% | −36.8% | −19.4% | 189.7% | −63.0% | −62.0% | −65.1% | −85.7% | −56.4% |
| Return on invested capital (ROIC) | −68.9% | −98.6% | −121.4% | −79.6% | −198.8% | — | −513.3% | — | — | — |
| Return on assets (ROA) | −27.9% | 51.8% | −32.4% | −17.3% | 140.1% | −37.5% | −47.0% | −47.0% | −51.0% | −38.2% |
| Return on tangible assets | −31.8% | 40.5% | −37.6% | −18.7% | 111.6% | −38.4% | −46.2% | −40.3% | −51.2% | −32.1% |
| Free cash flow margin | −698.3% | — | — | — | — | −150.0% | −324.6% | −329.9% | −673.9% | 41.0% |
| Income quality (OCF / net income) | — | −0.58 | — | — | −0.25 | — | — | — | — | — |
| Financial health | ||||||||||
| Total debt | $40.2M | $57.0M | $72.0M | $85.7M | $97.1M | $105.2M | $113.7M | $59.8M | $125.8M | $154.3M |
| Cash & short-term investments | $854.4M | $893.7M | $776.9M | $783.1M | $1.02B | $572.9M | $564.9M | $805.4M | $567.8M | $573.6M |
| Net debt | −$814.2M | −$836.7M | −$704.9M | −$697.5M | −$922.9M | −$467.7M | −$451.2M | −$745.6M | −$442.0M | −$419.3M |
| Debt / equity | 0.03 | 0.04 | 0.09 | 0.08 | 0.08 | 0.26 | 0.18 | 0.09 | 0.34 | 0.43 |
| Debt / assets | 0.03 | 0.03 | 0.08 | 0.07 | 0.07 | 0.12 | 0.13 | 0.07 | 0.20 | 0.25 |
| Net debt / EBITDA | — | −1.16 | — | — | — | — | — | — | — | — |
| Current ratio | 11.46 | 11.90 | 12.27 | 13.30 | 17.79 | 6.74 | 6.59 | 6.56 | 4.69 | 6.33 |
| Quick ratio | 11.06 | 11.56 | 11.99 | 13.16 | 17.52 | 6.59 | 6.51 | 6.55 | 6.20 | 6.70 |
| Interest coverage | — | — | — | -30.4 | -452.7 | -18.8 | -28.7 | -22.0 | -52.4 | -79.9 |
| Working capital | $859.8M | $884.4M | $765.9M | $770.1M | $1.00B | $542.3M | $518.8M | $520.3M | $350.3M | $471.5M |
| Invested capital | $378.9M | $704.2M | $106.1M | $403.4M | $369.1M | −$68.2M | $189.3M | −$58.1M | −$66.4M | −$60.7M |
| Tangible asset value | $1.19B | $1.54B | $811.0M | $1.10B | $1.29B | $399.5M | $640.5M | $687.5M | $375.5M | $358.6M |
| Net current asset value | $837.9M | $843.4M | $707.7M | $694.9M | $918.5M | $183.2M | $361.5M | $442.9M | $206.4M | $299.4M |
| Graham number | — | $83.49 | — | — | $112.99 | — | — | — | — | — |
| Graham net-net per share | $13.36 | $13.62 | $11.90 | $11.88 | $14.65 | $2.11 | $5.50 | $11.19 | $5.58 | $7.75 |
| Capital allocation | ||||||||||
| Dividends paid | — | — | — | — | $37.3M | — | — | — | $0 | $0 |
| Share buybacks (net) | — | — | $0 | $0 | $802.5M | $0 | $0 | $0 | $0 | $0 |
| Dividend payout ratio | — | — | — | — | 2.3% | — | — | — | — | — |
| Dividends + buybacks / free cash flow | — | — | — | — | — | — | — | — | — | 0.0% |
| Capex / revenue | 8.0% | 4.6% | 3.7% | 34.3% | 13,864.1% | 6.9% | 10.3% | 7.4% | 10.8% | 14.2% |
| Capex / operating cash flow | — | — | — | — | — | — | — | — | — | 25.7% |
| Capex / depreciation | 0.83 | 0.30 | 0.15 | 0.57 | 0.62 | 0.75 | 1.50 | 0.97 | 0.72 | 1.74 |
| Stock-based compensation / revenue | 97.3% | 117.4% | 166.9% | 346.2% | 129,218.3% | 30.3% | 61.4% | 77.7% | 111.2% | 60.2% |
| R&D / revenue | 618.9% | 825.5% | 1,077.1% | 1,965.7% | 620,572.8% | 103.9% | 348.5% | 361.6% | 680.5% | 315.0% |
| SG&A / revenue | 333.7% | 429.6% | 447.0% | 854.4% | 293,281.7% | 73.4% | 112.0% | 120.9% | 165.4% | 72.6% |
| Efficiency | ||||||||||
| Days sales outstanding | 49.6 | 34.6 | 34.1 | 84.4 | 131,234.8 | 36.6 | 39.9 | 27.6 | 51.6 | 52.0 |
| Days of inventory on hand | 958.8 | 2,045.9 | 529.4 | 2,643.5 | 300.2 | 214.2 | 1,136.3 | -18,673.9 | -109.8 | -75.6 |
| Days payables outstanding | 554.3 | 1,157.8 | 545.3 | 3,782.4 | 334.6 | 385.2 | 5,511.9 | 5,310.0 | 24.9 | 26.4 |
| Cash conversion cycle (days) | 454.1 | 922.7 | 18.2 | -1,054.5 | 131,200.4 | -134.4 | -4,335.7 | -23,956.3 | -83.1 | -50.0 |
| Receivables turnover | 7.36 | 10.55 | 10.69 | 4.33 | 0.00 | 9.98 | 9.15 | 13.22 | 7.08 | 7.02 |
| Payables turnover | 0.66 | 0.32 | 0.67 | 0.10 | 1.09 | 0.95 | 0.07 | 0.07 | 14.68 | 13.82 |
| Inventory turnover | 0.38 | 0.18 | 0.69 | 0.14 | 1.22 | 1.70 | 0.32 | — | — | — |
| Asset turnover | 0.04 | 0.03 | 0.02 | 0.01 | 0.00 | 0.23 | 0.13 | 0.13 | 0.07 | 0.13 |
| Average receivables | $7.3M | $3.5M | $2.5M | $3.3M | $14.9M | $20.4M | $12.9M | $7.1M | $6.1M | $10.0M |
| Average payables | $17.5M | $13.2M | $14.2M | $17.7M | $17.2M | $19.8M | $19.9M | $20.3M | $19.9M | $15.9M |
| Average inventory | $30.3M | $23.3M | $13.8M | $12.3M | $15.4M | $11.0M | $4.1M | −$71.5M | −$88.0M | −$45.6M |
| Intangibles / total assets | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
Computed from AGIO's annual financial statements (latest annual report filed February 12, 2026) and the closing share price on each fiscal year-end, adjusted for stock splits. Figures in U.S. dollars; data from EODHD. Averages use the opening and closing balance of each year.
AGIO valuation and financial ratios
Agios Pharmaceuticals earned a return on equity of −30.2% and a return on invested capital of −68.9% in fiscal 2025. It ended the year with $40.2 million of debt and $854.4 million in cash and short-term investments, a net cash position of $814.2 million. The share count rose 48.2% from 39.1M to 58.0M over 9 years.
See the AGIO income statement, the AGIO chart for price history, or the AGIO stock overview for the latest quote and news.
AGIO key metrics FAQ
What is Agios Pharmaceuticals's return on equity?
Agios Pharmaceuticals's return on equity (ROE) was −30.2% in fiscal 2025: net income of -$412.8 million on average shareholders' equity of $1.4 billion.
What is Agios Pharmaceuticals's ROIC?
Agios Pharmaceuticals's return on invested capital was −68.9% in fiscal 2025, using after-tax operating income divided by average debt plus equity minus cash.
How much debt does Agios Pharmaceuticals have?
Agios Pharmaceuticals had total debt of $40.2 million at the end of fiscal 2025, a debt-to-equity ratio of 0.03 and more cash than debt.
What is Agios Pharmaceuticals's free cash flow yield?
Agios Pharmaceuticals generated -$377.3 million of free cash flow in fiscal 2025, a free cash flow yield of −23.9% on its market value at year-end ($1.6 billion).
What is Agios Pharmaceuticals's current ratio?
Agios Pharmaceuticals's current ratio was 11.46 at the end of fiscal 2025: current assets were 11.46 times current liabilities.