Spruce Biosciences, Inc. (SPRB) Ownership
SPRB ownership summary
as of October 18, 2026- Institutions
- 76.9% of shares outstanding
- Insiders
- 3.37% of shares outstanding
- Shares outstanding
- 2.9M
- Float
- 2.0M shares available to trade
- Short interest
- 15.17% 432K shares short
- Days to cover
- 4.02 short interest up 3.7% vs prior month
- Institutions 76.87%
- Insiders 3.37%
- Other investors 19.76%
SPRB top institutional holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | AIGH Capital Management, LLC | 8.70% | 250K | $9.9M | +250,000 (0.0%) | June 30, 2026 |
| 2 | Orbimed Advisors LLC | 6.96% | 200K | $7.9M | +200,000 (0.0%) | June 30, 2026 |
| 3 | BlackRock Inc | 6.54% | 188K | $7.4M | +170,898 (+1,009.0%) | June 30, 2026 |
| 4 | Millennium Management LLC | 5.60% | 161K | $6.4M | +49,093 (+43.9%) | June 30, 2026 |
| 5 | Ikarian Capital, LLC | 4.22% | 121K | $4.8M | — | June 30, 2026 |
| 6 | Vanguard Capital Management, LLC | 4.15% | 119K | $4.7M | +100,994 (+550.8%) | June 30, 2026 |
| 7 | Alyeska Investment Group, L.P. | 2.84% | 82K | $3.2M | +30,000 (+58.1%) | June 30, 2026 |
| 8 | Geode Capital Management, LLC | 2.45% | 71K | $2.8M | +57,659 (+447.4%) | June 30, 2026 |
| 9 | ADAR1 Capital Management LLC | 2.36% | 68K | $2.7M | +9,117 (+15.6%) | June 30, 2026 |
| 10 | Cable Car Capital LLC | 2.09% | 60K | $2.4M | +60,000 (0.0%) | June 30, 2026 |
| 11 | Citadel Advisors Llc | 1.81% | 52K | $2.1M | −18,094 (−25.8%) | June 30, 2026 |
| 12 | State Street Corp | 1.76% | 50K | $2.0M | +45,050 (+834.3%) | June 30, 2026 |
| 13 | BOOTHBAY FUND MANAGEMENT, LLC | 1.46% | 42K | $1.7M | — | June 30, 2026 |
| 14 | StemPoint Capital LP | 1.44% | 41K | $1.6M | +28,668 (+225.4%) | June 30, 2026 |
| 15 | Eversept Partners, LP | 1.39% | 40K | $1.6M | +40,000 (0.0%) | June 30, 2026 |
| 16 | The Carlyle Group Inc | 1.34% | 39K | $1.5M | — | June 30, 2026 |
| 17 | The Goldman Sachs Group Inc | 1.13% | 32K | $1.3M | +26,842 (+487.5%) | June 30, 2026 |
| 18 | Affinity Asset Advisors, LLC | 1.04% | 30K | $1.2M | +30,000 (0.0%) | June 30, 2026 |
| 19 | Diadema Partners LP | 1.04% | 30K | $1.2M | +20,000 (+200.0%) | June 30, 2026 |
| 20 | Stonepine Capital Management Llc | 1.00% | 29K | $1.1M | +28,795 (0.0%) | June 30, 2026 |
Value at the latest close. Change = shares bought or sold in the latest quarterly filing (13F). In the top 20, 16 holders added 1.1M shares and 1 cut 18K.
SPRB top mutual fund and ETF holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | Vanguard MStar Total Stk Mkt Idx Invest | 2.96% | 85K | $3.4M | — | August 31, 2026 |
| 2 | iShares Russell 2000 ETF | 2.40% | 69K | $2.7M | −768 (−1.1%) | September 30, 2026 |
| 3 | Biotech Growth Ord | 2.36% | 68K | $2.7M | — | June 30, 2026 |
| 4 | Fidelity Small Cap Index | 1.03% | 30K | $1.2M | +260 (+0.9%) | July 31, 2026 |
| 5 | iShares Russell 2000 Value ETF | 0.62% | 18K | $706,960 | +28 (+0.2%) | September 30, 2026 |
| 6 | Vanguard Russell 2000 ETF | 0.54% | 16K | $618,421 | +360 (+2.4%) | August 31, 2026 |
| 7 | Fidelity Extended Market Index | 0.46% | 13K | $520,723 | −71 (−0.5%) | August 31, 2026 |
| 8 | iShares Micro-Cap ETF | 0.27% | 7,853 | $311,371 | −54 (−0.7%) | September 30, 2026 |
| 9 | Schwab Small Cap Index | 0.24% | 6,797 | $269,501 | — | August 31, 2026 |
| 10 | iShares Russell 2000 Growth ETF | 0.23% | 6,587 | $261,175 | −8 (−0.1%) | September 30, 2026 |
| 11 | Fidelity Total Market Index | 0.22% | 6,370 | $252,570 | — | August 31, 2026 |
| 12 | iShares Russell 2000 Small-Cap Idx Instl | 0.18% | 5,082 | $201,501 | — | August 31, 2026 |
| 13 | Fidelity Series Total Market Index | 0.15% | 4,256 | $168,750 | −649 (−13.2%) | August 31, 2026 |
| 14 | Dimensional US Small Cap ETF | 0.13% | 3,751 | $148,727 | — | September 30, 2026 |
| 15 | Nuveen Small Cap Blend Idx R6 | 0.13% | 3,660 | $145,119 | — | August 31, 2026 |
| 16 | EQ/2000 Managed Volatility IB | 0.10% | 2,934 | $116,333 | — | August 31, 2026 |
| 17 | Fidelity Small Cap Value Index | 0.10% | 2,837 | $112,487 | — | July 31, 2026 |
| 18 | Xtrackers Russell 2000 ETF 1C | 0.09% | 2,489 | $98,689 | +105 (+4.4%) | August 31, 2026 |
| 19 | DFA US Micro Cap I | 0.08% | 2,219 | $87,983 | +251 (+12.8%) | August 31, 2026 |
| 20 | LVIP SSgA Small Cap Index Std | 0.07% | 2,100 | $83,265 | +2,100 (0.0%) | June 30, 2026 |
Funds report holdings monthly or quarterly; dates differ by fund.
SPRB insider transactions
latest 2| Date | Name | Transaction | Price | Shares | Value |
|---|---|---|---|---|---|
| 2025-10-06 | Parkman Healthcare Partners Ll | Buy | $17.91 | 256 | $4,585 |
| 2025-10-06 | Parkman Healthcare Partners Ll | Sell | $19.14 | 257 | $4,919 |
Reported trades by company officers, directors and other filers (including disclosures by members of Congress where EODHD lists them). "—" where the filing gives no share count.
SPRB shares outstanding
Year-end shares outstanding, adjusted for splits.
Who owns SPRB
Institutional investors own 76.9% of Spruce Biosciences's shares and insiders 3.37%. The largest holder is AIGH Capital Management, LLC with 8.70% of the shares (250K), as of June 30, 2026. Among the top 20 institutions, 16 added shares and 1 reduced their stake in the latest filings. Short interest is 15.17% of the float, or 4.02 days of average trading volume. The share count rose 29.5% since 2019.
Related: SPRB analyst forecast, SPRB key metrics. See the SPRB stock overview for the latest quote and news.
SPRB ownership FAQ
Who owns the most Spruce Biosciences stock?
The largest shareholders of Spruce Biosciences are AIGH Capital Management, LLC (8.70%), Orbimed Advisors LLC (6.96%), BlackRock Inc (6.54%), Millennium Management LLC (5.60%), Ikarian Capital, LLC (4.22%).
What percentage of Spruce Biosciences is owned by institutions?
Institutions hold 76.9% of Spruce Biosciences's shares outstanding; insiders hold 3.37%.
Which funds own Spruce Biosciences?
The largest fund holders of Spruce Biosciences are Vanguard MStar Total Stk Mkt Idx Invest (2.96%), iShares Russell 2000 ETF (2.40%), Biotech Growth Ord (2.36%), Fidelity Small Cap Index (1.03%), iShares Russell 2000 Value ETF (0.62%).
What is Spruce Biosciences's short interest?
432K shares of Spruce Biosciences were sold short, 15.17% of the float; at the average daily volume it would take 4.02 days to cover.
Are insiders buying or selling Spruce Biosciences?
Of the latest 2 reported insider transactions in Spruce Biosciences (since October 6, 2025), 1 were purchases and 1 were sales.
How many shares of Spruce Biosciences are outstanding?
Spruce Biosciences has 2.9M shares outstanding, of which 2.0M are in the public float.