Karyopharm Therapeutics Inc. (KPTI) Ownership
KPTI ownership summary
as of October 18, 2026- Institutions
- 95.8% of shares outstanding
- Insiders
- 4.67% of shares outstanding
- Shares outstanding
- 22.7M
- Float
- 17.3M shares available to trade
- Short interest
- 26.84% 6.1M shares short
- Days to cover
- 4.17 short interest down 23.0% vs prior month
- Institutions 95.82%
- Insiders 4.67%
KPTI top institutional holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 8.45% | 1.9M | $747,768 | — | June 30, 2026 |
| 2 | Adage Capital Partners Gp LLC | 6.71% | 1.5M | $593,316 | −285,000 (−15.8%) | June 30, 2026 |
| 3 | The Goldman Sachs Group Inc | 6.28% | 1.4M | $555,617 | +477,079 (+50.3%) | June 30, 2026 |
| 4 | BlackRock Inc | 6.26% | 1.4M | $553,332 | +1.2M (+479.3%) | June 30, 2026 |
| 5 | Kalehua Capital Management LLC | 6.05% | 1.4M | $534,802 | +1.4M (0.0%) | June 30, 2026 |
| 6 | Vanguard Capital Management, LLC | 4.23% | 959K | $374,002 | +219,234 (+29.6%) | June 30, 2026 |
| 7 | Catalio Capital Management, LP | 4.15% | 941K | $366,933 | +43,146 (+4.8%) | June 30, 2026 |
| 8 | Avidity Partners Management LP | 4.08% | 924K | $360,550 | −2,995 (−0.3%) | June 30, 2026 |
| 9 | T. Rowe Price Investment Management,Inc. | 3.47% | 786K | $306,661 | −755,781 (−49.0%) | June 30, 2026 |
| 10 | Two Sigma Investments LLC | 3.07% | 695K | $271,153 | +544,032 (+359.7%) | June 30, 2026 |
| 11 | NEA Management Company, LLC | 2.54% | 577K | $224,944 | +576,780 (0.0%) | June 30, 2026 |
| 12 | Geode Capital Management, LLC | 2.34% | 531K | $207,180 | +325,098 (+157.7%) | June 30, 2026 |
| 13 | Ghisallo Capital Management LLC | 2.20% | 500K | $195,000 | +500,000 (0.0%) | June 30, 2026 |
| 14 | Soleus Capital Management, L.P. | 1.94% | 440K | $171,600 | — | June 30, 2026 |
| 15 | UBS Group AG | 1.56% | 354K | $137,883 | +159,528 (+82.2%) | June 30, 2026 |
| 16 | State Street Corp | 1.44% | 326K | $127,136 | +245,249 (+303.7%) | June 30, 2026 |
| 17 | Affinity Asset Advisors, LLC | 1.38% | 312K | $121,875 | −187,500 (−37.5%) | June 30, 2026 |
| 18 | Brevan Howard Capital Management LP | 1.37% | 310K | $120,829 | +97,450 (+45.9%) | June 30, 2026 |
| 19 | Millennium Management LLC | 1.35% | 306K | $119,214 | −114,895 (−27.3%) | June 30, 2026 |
| 20 | Boxer Capital Management, LLC | 1.33% | 303K | $117,989 | — | June 30, 2026 |
Value at the latest close. Change = shares bought or sold in the latest quarterly filing (13F). In the top 20, 12 holders added 5.7M shares and 5 cut 1.3M.
KPTI top mutual fund and ETF holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | Vanguard MStar Total Stk Mkt Idx Invest | 2.99% | 678K | $264,314 | — | August 31, 2026 |
| 2 | iShares Russell 2000 ETF | 2.17% | 493K | $192,196 | −5,696 (−1.1%) | September 30, 2026 |
| 3 | Fidelity Small Cap Index | 0.95% | 216K | $84,244 | +1,410 (+0.7%) | July 31, 2026 |
| 4 | Fidelity Enhanced Small Cap Core ETF | 0.80% | 181K | $70,446 | +378 (+0.2%) | September 30, 2026 |
| 5 | iShares Russell 2000 Value ETF | 0.68% | 154K | $60,154 | +234 (+0.2%) | September 30, 2026 |
| 6 | Vanguard Russell 2000 ETF | 0.51% | 115K | $44,998 | +1,596 (+1.4%) | September 30, 2026 |
| 7 | Fidelity Extended Market Index | 0.48% | 110K | $42,825 | −590 (−0.5%) | August 31, 2026 |
| 8 | Abante Quant Value FI | 0.44% | 100K | $39,130 | +30,743 (+44.2%) | August 31, 2026 |
| 9 | C WorldWide Healthcare Select 1A | 0.44% | 100K | $39,000 | — | June 30, 2026 |
| 10 | iShares Micro-Cap ETF | 0.28% | 64K | $24,905 | −440 (−0.7%) | September 30, 2026 |
| 11 | Invesco NASDAQ Future Gen 200 ETF | 0.26% | 58K | $22,572 | — | September 30, 2026 |
| 12 | Bridgeway Ultra-Small Company | 0.22% | 50K | $19,450 | — | June 30, 2026 |
| 13 | Schwab Small Cap Index | 0.21% | 49K | $18,923 | — | August 31, 2026 |
| 14 | Fidelity VIP Disciplined Small Cap Init | 0.21% | 48K | $18,673 | +39,827 (+494.6%) | July 31, 2026 |
| 15 | Fidelity Total Market Index | 0.18% | 40K | $15,503 | — | August 31, 2026 |
| 16 | iShares Russell 2000 Small-Cap Idx Instl | 0.16% | 37K | $14,520 | — | August 31, 2026 |
| 17 | Invesco Russell 2000® Dynamic Mltfct ETF | 0.16% | 36K | $13,921 | — | September 30, 2026 |
| 18 | Fidelity Series Total Market Index | 0.15% | 35K | $13,607 | — | August 31, 2026 |
| 19 | Nomura Healthcare Fund Class I | 0.15% | 33K | $13,000 | — | August 31, 2026 |
| 20 | Invesco RAFI US 1500 Small-Mid ETF | 0.14% | 32K | $12,594 | — | September 30, 2026 |
Funds report holdings monthly or quarterly; dates differ by fund.
KPTI insider transactions
latest 12| Date | Name | Transaction | Price | Shares | Value |
|---|---|---|---|---|---|
| 2026-04-21 | Reshma Rangwala | Sell | $8.94 | 449 | $4,014 |
| 2026-01-28 | Kristin Abate | Sell | $7.03 | 50 | $352 |
| 2026-01-21 | Kristin Abate | Sell | $5.96 | 265 | $1,579 |
| 2025-10-01 | Kristin Abate | Sell | $6.30 | 362 | $2,281 |
| 2025-09-15 | Kristin Abate | Sell | $6.43 | 23 | $148 |
| 2025-09-15 | Michael Mano | Sell | $6.43 | 234 | $1,505 |
| 2025-09-15 | Reshma Rangwala | Sell | $6.43 | 408 | $2,623 |
| 2025-09-15 | Sohanya Roshan Cheng | Sell | $6.43 | 325 | $2,090 |
| 2025-09-15 | Stuart Poulton | Sell | $6.43 | 401 | $2,578 |
| 2025-09-03 | Kristin Abate | Sell | $6.78 | 12 | $81 |
| 2025-07-29 | Stuart Poulton | Sell | $4.37 | 191 | $835 |
| 2025-07-22 | Kristin Abate | Sell | $4.00 | 238 | $952 |
Reported trades by company officers, directors and other filers (including disclosures by members of Congress where EODHD lists them). "—" where the filing gives no share count.
KPTI shares outstanding
Year-end shares outstanding, adjusted for splits.
Who owns KPTI
Institutional investors own 95.8% of Karyopharm Therapeutics's shares and insiders 4.67%. The largest holder is RA Capital Management, LLC with 8.45% of the shares (1.9M), as of June 30, 2026. Among the top 20 institutions, 12 added shares and 5 reduced their stake in the latest filings. Short interest is 26.84% of the float, or 4.17 days of average trading volume. The share count rose 736.4% since 2014.
Related: KPTI analyst forecast, KPTI key metrics. See the KPTI stock overview for the latest quote and news.
KPTI ownership FAQ
Who owns the most Karyopharm Therapeutics stock?
The largest shareholders of Karyopharm Therapeutics are RA Capital Management, LLC (8.45%), Adage Capital Partners Gp LLC (6.71%), The Goldman Sachs Group Inc (6.28%), BlackRock Inc (6.26%), Kalehua Capital Management LLC (6.05%).
What percentage of Karyopharm Therapeutics is owned by institutions?
Institutions hold 95.8% of Karyopharm Therapeutics's shares outstanding; insiders hold 4.67%.
Which funds own Karyopharm Therapeutics?
The largest fund holders of Karyopharm Therapeutics are Vanguard MStar Total Stk Mkt Idx Invest (2.99%), iShares Russell 2000 ETF (2.17%), Fidelity Small Cap Index (0.95%), Fidelity Enhanced Small Cap Core ETF (0.80%), iShares Russell 2000 Value ETF (0.68%).
What is Karyopharm Therapeutics's short interest?
6.1M shares of Karyopharm Therapeutics were sold short, 26.84% of the float; at the average daily volume it would take 4.17 days to cover.
Are insiders buying or selling Karyopharm Therapeutics?
Of the latest 12 reported insider transactions in Karyopharm Therapeutics (since July 22, 2025), 0 were purchases and 12 were sales.
How many shares of Karyopharm Therapeutics are outstanding?
Karyopharm Therapeutics has 22.7M shares outstanding, of which 17.3M are in the public float.