Ensysce Biosciences, Inc. (ENSC) Ownership

NASDAQ: ENSCTop holders, insider trades and short interest.

ENSC ownership summary

as of October 18, 2026
Institutions
4.7%
of shares outstanding
Insiders
4.72%
of shares outstanding
Shares outstanding
19.5M
Float
18.5M
shares available to trade
Short interest
5.56%
1.1M shares short
Days to cover
2.14
short interest down 10.4% vs prior month
  • Institutions 4.65%
  • Insiders 4.72%
  • Other investors 90.63%

ENSC top institutional holders

20 largest
Ensysce Biosciences, Inc. top institutional holders
#Holder% of sharesSharesValueChangeReported
1Jane Street Group LLC1.07%209K$108,175+195,263 (+1,438.9%)June 30, 2026
2Adage Capital Partners Gp LLC0.77%150K$77,550—June 30, 2026
3Virtu Financial LLC0.49%95K$49,413+82,078 (+616.5%)June 30, 2026
4Perceptive Advisors LLC0.45%87K$44,893—June 30, 2026
5Citadel Advisors Llc0.44%86K$44,648+28,830 (+50.3%)June 30, 2026
6XTX Topco Ltd0.40%77K$39,889+52,642 (+216.1%)June 30, 2026
7Geode Capital Management, LLC0.32%62K$32,213−11,692 (−15.8%)June 30, 2026
8HRT FINANCIAL LLC0.28%54K$28,194+54,429 (0.0%)June 30, 2026
9Susquehanna International Group, LLP0.18%34K$17,757+34,280 (0.0%)June 30, 2026
10TRU INDEPENDENCE ASSET MANAGEMENT 2, LLC0.07%13K$6,734—June 30, 2026
11TWO SIGMA SECURITIES, LLC0.07%13K$6,710+12,953 (0.0%)June 30, 2026
12Vanguard Capital Management, LLC0.07%13K$6,658—June 30, 2026
13Tower Research Capital LLC0.03%6,094$3,157—June 30, 2026
14Barclays PLC0.01%1,440$746+1,440 (0.0%)June 30, 2026
15SBI Securities Co Ltd<0.01%641$332+155 (+31.9%)June 30, 2026
16BlackRock Inc<0.01%65$34—June 30, 2026
17DRW Securities, LLC0.00%——−98,481 (−100.0%)March 31, 2026
18Williams & Novak LLC0.00%——−17,850 (−100.0%)March 31, 2026
19UBS Group AG0.00%——−8,791 (−100.0%)June 30, 2026
20FNY Investment Advisers, LLC0.00%——−3,000 (−100.0%)June 30, 2026

Value at the latest close. Change = shares bought or sold in the latest quarterly filing (13F). In the top 20, 9 holders added 462K shares and 5 cut 140K.

ENSC top mutual fund and ETF holders

1 largest
Ensysce Biosciences, Inc. top fund holders
#Holder% of sharesSharesValueChangeReported
1Fidelity Extended Market Index0.31%61K$31,443−326 (−0.5%)August 31, 2026

Funds report holdings monthly or quarterly; dates differ by fund.

ENSC insider transactions

latest 1
Ensysce Biosciences, Inc. insider transactions
DateNameTransactionPriceSharesValue
2023-03-02Bob G GowerBuy$88.20501$44,188

Reported trades by company officers, directors and other filers (including disclosures by members of Congress where EODHD lists them). "—" where the filing gives no share count.

ENSC shares outstanding

Shares outstanding

Year-end shares outstanding, adjusted for splits.

Who owns ENSC

Institutional investors own 4.7% of Ensysce Biosciences's shares and insiders 4.72%. The largest holder is Jane Street Group LLC with 1.07% of the shares (209K), as of June 30, 2026. Among the top 20 institutions, 9 added shares and 5 reduced their stake in the latest filings. Short interest is 5.56% of the float, or 2.14 days of average trading volume. The share count rose 327.4% since 2017.

Related: ENSC analyst forecast, ENSC key metrics. See the ENSC stock overview for the latest quote and news.

ENSC ownership FAQ

Who owns the most Ensysce Biosciences stock?

The largest shareholders of Ensysce Biosciences are Jane Street Group LLC (1.07%), Adage Capital Partners Gp LLC (0.77%), Virtu Financial LLC (0.49%), Perceptive Advisors LLC (0.45%), Citadel Advisors Llc (0.44%).

What percentage of Ensysce Biosciences is owned by institutions?

Institutions hold 4.7% of Ensysce Biosciences's shares outstanding; insiders hold 4.72%.

Which funds own Ensysce Biosciences?

The largest fund holders of Ensysce Biosciences are Fidelity Extended Market Index (0.31%).

What is Ensysce Biosciences's short interest?

1.1M shares of Ensysce Biosciences were sold short, 5.56% of the float; at the average daily volume it would take 2.14 days to cover.

Are insiders buying or selling Ensysce Biosciences?

Of the latest 1 reported insider transactions in Ensysce Biosciences (since March 2, 2023), 1 were purchases and 0 were sales.

How many shares of Ensysce Biosciences are outstanding?

Ensysce Biosciences has 19.5M shares outstanding, of which 18.5M are in the public float.

Biotechnology: ownership