Tyra Biosciences, Inc. (TYRA) Ownership
TYRA ownership summary
as of October 18, 2026- Institutions
- 108.3% of shares outstanding
- Insiders
- 2.43% of shares outstanding
- Shares outstanding
- 68.8M
- Float
- 34.7M shares available to trade
- Short interest
- 22.71% 9.4M shares short
- Days to cover
- 6.85 short interest down 4.7% vs prior month
- Institutions 108.29%
- Insiders 2.43%
TYRA top institutional holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 17.74% | 12.2M | $225.9M | — | June 30, 2026 |
| 2 | FMR Inc | 12.97% | 8.9M | $165.2M | +1.2M (+15.1%) | June 30, 2026 |
| 3 | Jupiter Topco LLC | 6.33% | 4.4M | $80.6M | +4.4M (0.0%) | June 30, 2026 |
| 4 | HHG PLC | 5.66% | 3.9M | $72.1M | +955,147 (+32.5%) | March 31, 2026 |
| 5 | Alta Partners Management Company, L.P. | 5.56% | 3.8M | $70.8M | — | June 30, 2026 |
| 6 | Nextech Invest, Ltd. | 5.17% | 3.6M | $65.8M | −502,276 (−12.4%) | June 30, 2026 |
| 7 | TCG Crossover Management, LLC | 4.73% | 3.2M | $60.2M | — | June 30, 2026 |
| 8 | BlackRock Inc | 4.41% | 3.0M | $56.2M | +814,043 (+36.7%) | June 30, 2026 |
| 9 | T. Rowe Price Associates, Inc. | 4.05% | 2.8M | $51.5M | +1.8M (+182.2%) | June 30, 2026 |
| 10 | State Street Corp | 3.11% | 2.1M | $39.6M | +924,290 (+76.0%) | June 30, 2026 |
| 11 | COMMODORE CAPITAL LP | 2.73% | 1.9M | $34.7M | −600,000 (−24.2%) | June 30, 2026 |
| 12 | Paradigm Biocapital Advisors LP | 2.66% | 1.8M | $33.9M | −226,384 (−11.0%) | June 30, 2026 |
| 13 | Vanguard Capital Management, LLC | 2.19% | 1.5M | $27.9M | +382,477 (+34.0%) | June 30, 2026 |
| 14 | Bvf Inc | 2.15% | 1.5M | $27.3M | −500,000 (−25.3%) | June 30, 2026 |
| 15 | 5AM Venture Management, LLC | 1.50% | 1.0M | $19.1M | — | June 30, 2026 |
| 16 | Deerfield Management Co | 1.48% | 1.0M | $18.8M | +468,000 (+85.2%) | June 30, 2026 |
| 17 | Hood River Capital Management LLC | 1.48% | 1.0M | $18.8M | +1.0M (0.0%) | June 30, 2026 |
| 18 | Geode Capital Management, LLC | 1.41% | 971K | $18.0M | +312,252 (+47.4%) | June 30, 2026 |
| 19 | Caligan Partners LP | 1.17% | 807K | $14.9M | −469,982 (−36.8%) | June 30, 2026 |
| 20 | Canaan Partners XI LLC | 1.09% | 750K | $13.9M | — | June 30, 2026 |
Value at the latest close. Change = shares bought or sold in the latest quarterly filing (13F). In the top 20, 10 holders added 12.2M shares and 5 cut 2.3M.
TYRA top mutual fund and ETF holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | Fidelity OTC | 4.82% | 3.3M | $61.4M | +21,352 (+0.6%) | August 31, 2026 |
| 2 | State Street® SPDR® S&P® Biotech ETF | 1.69% | 1.2M | $21.5M | −22,200 (−1.9%) | September 30, 2026 |
| 3 | Vanguard MStar Total Stk Mkt Idx Invest | 1.65% | 1.1M | $21.0M | — | August 31, 2026 |
| 4 | iShares Russell 2000 ETF | 1.39% | 957K | $17.7M | −11,008 (−1.1%) | September 30, 2026 |
| 5 | T. Rowe Price New Horizons | 1.21% | 833K | $15.4M | +110,952 (+15.4%) | September 30, 2026 |
| 6 | Fidelity Advisor Equity Growth I | 0.99% | 679K | $12.6M | — | August 31, 2026 |
| 7 | Janus Henderson Hrzn Biotec E2 USD | 0.95% | 653K | $12.1M | +132,469 (+25.5%) | June 30, 2026 |
| 8 | Fidelity VIP Growth Initial | 0.92% | 631K | $11.7M | — | August 31, 2026 |
| 9 | T. Rowe Price Integrated US Sm Gr Eq | 0.86% | 589K | $10.9M | — | September 30, 2026 |
| 10 | Franklin Biotechnology Discv A(acc)USD | 0.79% | 545K | $10.1M | +332,288 (+156.5%) | September 30, 2026 |
| 11 | Hood River Small-Cap Growth Instl | 0.72% | 492K | $9.1M | +492,217 (0.0%) | June 30, 2026 |
| 12 | iShares Biotechnology ETF | 0.60% | 412K | $7.6M | +68,197 (+19.8%) | September 30, 2026 |
| 13 | Fidelity Small Cap Index | 0.58% | 402K | $7.4M | +3,536 (+0.9%) | July 31, 2026 |
| 14 | Fidelity Stock Selector Small Cap | 0.57% | 390K | $7.2M | +200 (+0.1%) | July 31, 2026 |
| 15 | Fidelity Small Cap Growth | 0.54% | 375K | $6.9M | — | July 31, 2026 |
| 16 | Janus Henderson Triton D | 0.52% | 357K | $6.6M | — | August 31, 2026 |
| 17 | Fidelity Advisor Biotechnology I | 0.52% | 354K | $6.6M | — | August 31, 2026 |
| 18 | iShares Russell 2000 Growth ETF | 0.50% | 343K | $6.3M | −434 (−0.1%) | September 30, 2026 |
| 19 | Fidelity Growth Discovery | 0.50% | 342K | $6.3M | — | August 31, 2026 |
| 20 | Fidelity Select Biotechnology | 0.49% | 337K | $6.2M | — | August 31, 2026 |
Funds report holdings monthly or quarterly; dates differ by fund.
TYRA insider transactions
latest 8| Date | Name | Transaction | Price | Shares | Value |
|---|---|---|---|---|---|
| 2026-03-25 | Gilla Kaplan | Sell | $36.97 | 14,295 | $528,486 |
| 2025-12-19 | Robert J More | Sell | $25.00 | 10,000 | $250,000 |
| 2025-11-21 | Robert J More | Sell | $20.25 | 246,871 | $5.0M |
| 2025-06-18 | Gilla Kaplan | Sell | $9.78 | 9,568 | $93,575 |
| 2025-06-17 | Gilla Kaplan | Sell | $10.35 | 10 | $104 |
| 2025-06-16 | Gilla Kaplan | Sell | $10.38 | 6,814 | $70,729 |
| 2025-06-13 | Gilla Kaplan | Sell | $10.31 | 15,000 | $154,650 |
| 2025-06-12 | Gilla Kaplan | Sell | $10.31 | 30,000 | $309,300 |
Reported trades by company officers, directors and other filers (including disclosures by members of Congress where EODHD lists them). "—" where the filing gives no share count.
TYRA shares outstanding
Year-end shares outstanding, adjusted for splits.
Who owns TYRA
Institutional investors own 108.3% of Tyra Biosciences's shares and insiders 2.43%. The largest holder is RA Capital Management, LLC with 17.74% of the shares (12.2M), as of June 30, 2026. Among the top 20 institutions, 10 added shares and 5 reduced their stake in the latest filings. Short interest is 22.71% of the float, or 6.85 days of average trading volume. The share count rose 165.1% since 2020.
Related: TYRA analyst forecast, TYRA key metrics. See the TYRA stock overview for the latest quote and news.
TYRA ownership FAQ
Who owns the most Tyra Biosciences stock?
The largest shareholders of Tyra Biosciences are RA Capital Management, LLC (17.74%), FMR Inc (12.97%), Jupiter Topco LLC (6.33%), HHG PLC (5.66%), Alta Partners Management Company, L.P. (5.56%).
What percentage of Tyra Biosciences is owned by institutions?
Institutions hold 108.3% of Tyra Biosciences's shares outstanding; insiders hold 2.43%.
Which funds own Tyra Biosciences?
The largest fund holders of Tyra Biosciences are Fidelity OTC (4.82%), State Street® SPDR® S&P® Biotech ETF (1.69%), Vanguard MStar Total Stk Mkt Idx Invest (1.65%), iShares Russell 2000 ETF (1.39%), T. Rowe Price New Horizons (1.21%).
What is Tyra Biosciences's short interest?
9.4M shares of Tyra Biosciences were sold short, 22.71% of the float; at the average daily volume it would take 6.85 days to cover.
Are insiders buying or selling Tyra Biosciences?
Of the latest 8 reported insider transactions in Tyra Biosciences (since June 12, 2025), 0 were purchases and 8 were sales.
How many shares of Tyra Biosciences are outstanding?
Tyra Biosciences has 68.8M shares outstanding, of which 34.7M are in the public float.