Syros Pharmaceuticals, Inc. (SYRS) Ownership

OTC Pink: SYRSTop holders, insider trades and short interest.

SYRS ownership summary

as of October 21, 2026
Institutions
0.0%
of shares outstanding
Insiders
0.00%
of shares outstanding
Shares outstanding
26.8M
Float
26.8M
shares available to trade
Short interest
17.01%
913K shares short
Days to cover
0.09
short interest up 26.3% vs prior month
  • Other investors 100.00%

SYRS top institutional holders

20 largest
Syros Pharmaceuticals, Inc. top institutional holders
#Holder% of sharesSharesValueChangeReported
1Bain Capital Life Sciences Investors, LLC10.25%2.8M$1,100—December 31, 2024
2BlackRock Inc1.03%277K$111+15,674 (+6.0%)December 31, 2024
3Vanguard Group Inc1.00%268K$107−685,159 (−71.9%)December 31, 2024
4Omega Fund Management LLC0.94%251K$101—December 31, 2024
5Geode Capital Management, LLC0.73%196K$79−8,443 (−4.1%)December 31, 2024
6Affinity Asset Advisors, LLC0.56%150K$60+150,000 (0.0%)December 31, 2024
7Citigroup Inc0.52%139K$56+138,537 (+20,165.5%)December 31, 2024
8Qube Research & Technologies0.46%122K$49+44,458 (+57.2%)December 31, 2024
9TWO SIGMA SECURITIES, LLC0.40%108K$43+107,742 (0.0%)December 31, 2024
10Renaissance Technologies Corp0.36%96K$38−393 (−0.4%)December 31, 2024
11HRT FINANCIAL LLC0.33%88K$35+87,535 (0.0%)December 31, 2024
12XTX Topco Ltd0.30%81K$33+52,626 (+182.5%)December 31, 2024
13State Street Corp0.26%69K$28—December 31, 2024
14Jane Street Group LLC0.20%53K$21+52,920 (0.0%)December 31, 2024
15Two Sigma Investments LLC0.18%49K$20+20,386 (+71.6%)December 31, 2024
16UBS Group AG0.17%45K$18+28,322 (+169.3%)December 31, 2024
17Northern Trust Corp0.15%41K$16—December 31, 2024
181492 Capital Management, LLC0.15%39K$16—December 31, 2024
19Virtu Financial LLC0.12%33K$13+13,162 (+67.1%)December 31, 2024
20Baader Bank INC0.08%22K$9+22,092 (0.0%)December 31, 2024

Value at the latest close. Change = shares bought or sold in the latest quarterly filing (13F). In the top 20, 12 holders added 733K shares and 3 cut 694K.

SYRS top mutual fund and ETF holders

20 largest
Syros Pharmaceuticals, Inc. top fund holders
#Holder% of sharesSharesValueChangeReported
1Vanguard Institutional Extnd Mkt Idx Tr0.96%258K$103—January 31, 2025
2Fidelity Extended Market Index0.36%98K$39−1,064 (−1.1%)January 31, 2025
3iShares Micro-Cap ETF0.17%46K$18—February 28, 2025
4Extended Equity Market Fund K0.17%45K$18−616 (−1.4%)December 31, 2024
5Fidelity Total Market Index0.15%40K$16—January 31, 2025
6Fidelity Series Total Market Index0.09%24K$9—January 31, 2025
7Northern Trust Extended Eq Market Idx0.08%23K$9—December 31, 2024
8NT Ext Equity Mkt Idx Fd - L0.08%23K$9—December 31, 2024
9NT Ext Equity Mkt Idx Fd - NL0.06%17K$7—December 31, 2024
10NT Ext Equity Mkt Idx Fd - DC - NL - T20.05%13K$5−220 (−1.6%)December 31, 2024
11Spartan Total Market Index Pool E0.04%12K$5—January 31, 2025
12Vanguard U.S. Eq Idx £ Acc0.04%11K$4—January 31, 2025
13Fidelity Nasdaq Composite Index0.03%7,332$3—January 31, 2025
14State St US Extended Mkt Indx NL Cl C0.03%6,833$3—February 28, 2025
15Extended Equity Market Fund M0.02%5,812$2+56 (+1.0%)December 31, 2024
16NT Ext Eq Mkt Indx Fd DC Lend T30.02%5,386$2+5,386 (0.0%)December 31, 2024
17NT Ext Eq Mkt Indx Fd DC Lend T40.02%5,386$2+5,386 (0.0%)December 31, 2024
181290 VT Micro Cap K0.02%4,840$2—January 31, 2025
19NT Ext Eq Mkt Indx Fd DC Lending Tier 50.01%3,488$1+6 (+0.2%)September 30, 2024
20SSgA U.S. Total Market Index Strategy0.01%2,803$1+2,101 (+299.3%)June 30, 2024

Funds report holdings monthly or quarterly; dates differ by fund.

SYRS insider transactions

latest 7
Syros Pharmaceuticals, Inc. insider transactions
DateNameTransactionPriceSharesValue
2024-12-02Nancy A SimonianSell$0.2737,070$10,009
2024-11-25Nancy A SimonianSell$0.27134,713$36,373
2024-09-12Jason HaasBuy$1.6845,344$76,178
2024-09-10Conley CheeBuy$1.5150,000$75,500
2024-09-10Jason HaasBuy$1.5535,363$54,813
2024-06-28Richard A YoungSell$5.1234,837$178,365
2024-04-02David RothSell$4.98150$747

Reported trades by company officers, directors and other filers (including disclosures by members of Congress where EODHD lists them). "—" where the filing gives no share count.

SYRS shares outstanding

Shares outstanding

Year-end shares outstanding, adjusted for splits.

Who owns SYRS

Institutional investors own 0.0% of Syros Pharmaceuticals's shares and insiders 0.00%. The largest holder is Bain Capital Life Sciences Investors, LLC with 10.25% of the shares (2.8M), as of December 31, 2024. Among the top 20 institutions, 12 added shares and 3 reduced their stake in the latest filings. Short interest is 17.01% of the float, or 0.09 days of average trading volume. The share count rose 24,181.4% since 2014.

Related: SYRS analyst forecast, SYRS key metrics. See the SYRS stock overview for the latest quote and news.

SYRS ownership FAQ

Who owns the most Syros Pharmaceuticals stock?

The largest shareholders of Syros Pharmaceuticals are Bain Capital Life Sciences Investors, LLC (10.25%), BlackRock Inc (1.03%), Vanguard Group Inc (1.00%), Omega Fund Management LLC (0.94%), Geode Capital Management, LLC (0.73%).

What percentage of Syros Pharmaceuticals is owned by institutions?

Institutions hold 0.0% of Syros Pharmaceuticals's shares outstanding; insiders hold 0.00%.

Which funds own Syros Pharmaceuticals?

The largest fund holders of Syros Pharmaceuticals are Vanguard Institutional Extnd Mkt Idx Tr (0.96%), Fidelity Extended Market Index (0.36%), iShares Micro-Cap ETF (0.17%), Extended Equity Market Fund K (0.17%), Fidelity Total Market Index (0.15%).

What is Syros Pharmaceuticals's short interest?

913K shares of Syros Pharmaceuticals were sold short, 17.01% of the float; at the average daily volume it would take 0.09 days to cover.

Are insiders buying or selling Syros Pharmaceuticals?

Of the latest 7 reported insider transactions in Syros Pharmaceuticals (since April 2, 2024), 3 were purchases and 4 were sales.

How many shares of Syros Pharmaceuticals are outstanding?

Syros Pharmaceuticals has 26.8M shares outstanding, of which 26.8M are in the public float.

Biotechnology: ownership