Praxis Precision Medicines, Inc. (PRAX) Ownership
PRAX ownership summary
as of October 18, 2026- Institutions
- 123.4% of shares outstanding
- Insiders
- 0.28% of shares outstanding
- Shares outstanding
- 27.9M
- Float
- 24.1M shares available to trade
- Short interest
- 15.04% 4.2M shares short
- Days to cover
- 9.69 short interest up 10.3% vs prior month
- Institutions 123.45%
- Insiders 0.28%
PRAX top institutional holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | HHG PLC | 12.39% | 3.5M | $836.2M | +218,777 (+6.8%) | March 31, 2026 |
| 2 | Jupiter Topco LLC | 12.25% | 3.4M | $827.2M | +3.4M (0.0%) | June 30, 2026 |
| 3 | FMR Inc | 8.30% | 2.3M | $560.1M | +155,964 (+7.2%) | June 30, 2026 |
| 4 | BlackRock Inc | 8.21% | 2.3M | $554.3M | −32,344 (−1.4%) | June 30, 2026 |
| 5 | Perceptive Advisors LLC | 7.29% | 2.0M | $492.2M | — | June 30, 2026 |
| 6 | Baker Bros Advisors LP | 6.28% | 1.8M | $423.9M | — | June 30, 2026 |
| 7 | Orbis Allan Gray Ltd | 5.48% | 1.5M | $369.8M | −942,692 (−38.1%) | June 30, 2026 |
| 8 | Vanguard Portfolio Management, LLC | 4.78% | 1.3M | $322.8M | +578,437 (+76.4%) | June 30, 2026 |
| 9 | Vanguard Capital Management, LLC | 4.42% | 1.2M | $298.6M | +13,355 (+1.1%) | June 30, 2026 |
| 10 | State Street Corp | 3.68% | 1.0M | $248.2M | +142,205 (+16.1%) | June 30, 2026 |
| 11 | Adage Capital Partners Gp LLC | 3.64% | 1.0M | $245.5M | +199,741 (+24.5%) | June 30, 2026 |
| 12 | Deerfield Management Co | 3.45% | 963K | $232.9M | — | June 30, 2026 |
| 13 | Driehaus Capital Management LLC | 3.44% | 959K | $231.9M | +9,823 (+1.0%) | June 30, 2026 |
| 14 | T. Rowe Price Associates, Inc. | 3.38% | 943K | $228.0M | +312,147 (+49.5%) | June 30, 2026 |
| 15 | Morgan Stanley - Brokerage Accounts | 3.06% | 854K | $206.5M | +20,621 (+2.5%) | June 30, 2026 |
| 16 | Geode Capital Management, LLC | 2.68% | 748K | $180.8M | +97,135 (+14.9%) | June 30, 2026 |
| 17 | Cormorant Asset Management, LLC | 2.29% | 640K | $154.7M | −245,500 (−27.7%) | June 30, 2026 |
| 18 | The Goldman Sachs Group Inc | 1.97% | 549K | $132.7M | −161,904 (−22.8%) | June 30, 2026 |
| 19 | Bank of America Corp | 1.96% | 547K | $132.2M | +12,326 (+2.3%) | June 30, 2026 |
| 20 | Amvescap Plc. | 1.93% | 538K | $130.0M | +476,151 (+775.5%) | June 30, 2026 |
Value at the latest close. Change = shares bought or sold in the latest quarterly filing (13F). In the top 20, 13 holders added 5.7M shares and 4 cut 1.4M.
PRAX top mutual fund and ETF holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | Vanguard MStar Total Stk Mkt Idx Invest | 3.18% | 887K | $214.5M | −1,020 (−0.1%) | August 31, 2026 |
| 2 | iShares Russell 2000 ETF | 2.33% | 651K | $157.3M | −7,488 (−1.1%) | September 30, 2026 |
| 3 | Vanguard Small Cap Index | 2.30% | 642K | $155.1M | +939 (+0.1%) | August 31, 2026 |
| 4 | State Street® SPDR® S&P® Biotech ETF | 1.54% | 431K | $104.1M | −8,200 (−1.9%) | September 30, 2026 |
| 5 | Polar Capital Biotech S Inc | 1.50% | 417K | $100.9M | +153,342 (+58.1%) | August 31, 2026 |
| 6 | Fidelity Select Biotechnology | 1.47% | 411K | $99.5M | — | August 31, 2026 |
| 7 | Vanguard MStar Small Cap Value Index | 1.37% | 383K | $92.7M | +310 (+0.1%) | August 31, 2026 |
| 8 | Janus Henderson Global Life Sciences D | 1.29% | 361K | $87.2M | −18,500 (−4.9%) | August 31, 2026 |
| 9 | Janus Henderson Enterprise D | 1.28% | 358K | $86.6M | — | August 31, 2026 |
| 10 | Janus Global Life Science AUSD | 1.28% | 358K | $86.5M | −2,297 (−0.6%) | June 30, 2026 |
| 11 | Janus Henderson Glb Life Scn I2 USD | 1.24% | 347K | $83.9M | −10,842 (−3.0%) | August 31, 2026 |
| 12 | Orbis Global Equity Investor | 1.19% | 333K | $80.6M | −233,944 (−41.2%) | June 30, 2026 |
| 13 | Janus Henderson Hrzn Biotec E2 USD | 1.04% | 291K | $70.4M | +8,394 (+3.0%) | June 30, 2026 |
| 14 | Fidelity Small Cap Index | 0.98% | 275K | $66.4M | +2,297 (+0.8%) | July 31, 2026 |
| 15 | T. Rowe Price New Horizons | 0.91% | 255K | $61.7M | −7,390 (−2.8%) | August 31, 2026 |
| 16 | Janus Henderson Triton D | 0.89% | 248K | $59.9M | — | August 31, 2026 |
| 17 | iShares Russell 2000 Growth ETF | 0.84% | 235K | $56.9M | −298 (−0.1%) | September 30, 2026 |
| 18 | Orbis SICAV Global Bal Instl Inv | 0.76% | 212K | $51.3M | +82,367 (+63.4%) | March 31, 2026 |
| 19 | iShares Biotechnology ETF | 0.73% | 205K | $49.5M | −1,552 (−0.8%) | September 30, 2026 |
| 20 | Fidelity Small Cap Growth | 0.67% | 187K | $45.2M | +35,200 (+23.2%) | July 31, 2026 |
Funds report holdings monthly or quarterly; dates differ by fund.
PRAX insider transactions
latest 2| Date | Name | Transaction | Price | Shares | Value |
|---|---|---|---|---|---|
| 2025-11-20 | Alex Nemiroff | Sell | $193.09 | 25,130 | $4.9M |
| 2025-11-20 | Lauren Mastrocola | Sell | $192.08 | 13,600 | $2.6M |
Reported trades by company officers, directors and other filers (including disclosures by members of Congress where EODHD lists them). "—" where the filing gives no share count.
PRAX shares outstanding
Year-end shares outstanding, adjusted for splits.
Who owns PRAX
Institutional investors own 123.4% of Praxis Precision Medicines's shares and insiders 0.28%. The largest holder is HHG PLC with 12.39% of the shares (3.5M), as of March 31, 2026. Among the top 20 institutions, 13 added shares and 4 reduced their stake in the latest filings. Short interest is 15.04% of the float, or 9.69 days of average trading volume. The share count rose 1,865.1% since 2019.
Related: PRAX analyst forecast, PRAX key metrics. See the PRAX stock overview for the latest quote and news.
PRAX ownership FAQ
Who owns the most Praxis Precision Medicines stock?
The largest shareholders of Praxis Precision Medicines are HHG PLC (12.39%), Jupiter Topco LLC (12.25%), FMR Inc (8.30%), BlackRock Inc (8.21%), Perceptive Advisors LLC (7.29%).
What percentage of Praxis Precision Medicines is owned by institutions?
Institutions hold 123.4% of Praxis Precision Medicines's shares outstanding; insiders hold 0.28%.
Which funds own Praxis Precision Medicines?
The largest fund holders of Praxis Precision Medicines are Vanguard MStar Total Stk Mkt Idx Invest (3.18%), iShares Russell 2000 ETF (2.33%), Vanguard Small Cap Index (2.30%), State Street® SPDR® S&P® Biotech ETF (1.54%), Polar Capital Biotech S Inc (1.50%).
What is Praxis Precision Medicines's short interest?
4.2M shares of Praxis Precision Medicines were sold short, 15.04% of the float; at the average daily volume it would take 9.69 days to cover.
Are insiders buying or selling Praxis Precision Medicines?
Of the latest 2 reported insider transactions in Praxis Precision Medicines (since November 20, 2025), 0 were purchases and 2 were sales.
How many shares of Praxis Precision Medicines are outstanding?
Praxis Precision Medicines has 27.9M shares outstanding, of which 24.1M are in the public float.