Gyre Therapeutics, Inc. (GYRE) Ownership

NASDAQ: GYRETop holders, insider trades and short interest.

GYRE ownership summary

as of October 18, 2026
Institutions
8.2%
of shares outstanding
Insiders
74.40%
of shares outstanding
Shares outstanding
106.0M
Float
35.9M
shares available to trade
Short interest
6.45%
1.9M shares short
Days to cover
10.40
short interest up 10.9% vs prior month
  • Institutions 8.23%
  • Insiders 74.40%
  • Other investors 17.37%

GYRE top institutional holders

20 largest
Gyre Therapeutics, Inc. top institutional holders
#Holder% of sharesSharesValueChangeReported
1HSG Holding Ltd3.54%3.8M$22.8M+3.8M (0.0%)June 30, 2026
2BlackRock Inc0.94%994K$6.0M+235,313 (+31.0%)June 30, 2026
3Octagon Capital Advisors LP0.90%954K$5.8M+954,416 (0.0%)June 30, 2026
4Vanguard Capital Management, LLC0.83%877K$5.3M−107,277 (−10.9%)June 30, 2026
5Geode Capital Management, LLC0.50%533K$3.2M+101,536 (+23.5%)June 30, 2026
6State Street Corp0.23%245K$1.5M+29,076 (+13.4%)June 30, 2026
7Charles Schwab Investment Management Inc0.17%184K$1.1M+19,048 (+11.5%)June 30, 2026
8Northern Trust Corp0.16%170K$1.0M+35,696 (+26.7%)June 30, 2026
9SBI Securities Co Ltd0.16%167K$1.0M−4,087 (−2.4%)June 30, 2026
10Vanguard Fiduciary Trust Co0.14%151K$918,524+13,391 (+9.7%)June 30, 2026
11Vanguard Portfolio Management, LLC0.12%124K$753,634+54,139 (+77.5%)June 30, 2026
12The Goldman Sachs Group Inc0.08%86K$524,309+13,113 (+17.9%)June 30, 2026
13Bank of New York Mellon Corp0.06%63K$381,520+19,606 (+45.4%)June 30, 2026
14Morgan Stanley - Brokerage Accounts0.04%42K$253,481+33,050 (+382.5%)June 30, 2026
15STRS OHIO0.02%26K$156,864+4,700 (+22.3%)June 30, 2026
16Dimensional Fund Advisors, Inc.0.02%25K$153,629—June 30, 2026
17AllianceBernstein L.P.0.02%25K$149,507+2,760 (+12.6%)June 30, 2026
18Nuveen, LLC0.02%25K$148,990+24,505 (0.0%)June 30, 2026
19UBS Group AG0.02%19K$114,079−2,324 (−11.0%)June 30, 2026
20Millennium Management LLC0.02%18K$112,407+18,488 (0.0%)June 30, 2026

Value at the latest close. Change = shares bought or sold in the latest quarterly filing (13F). In the top 20, 16 holders added 5.3M shares and 3 cut 114K.

GYRE top mutual fund and ETF holders

18 largest
Gyre Therapeutics, Inc. top fund holders
#Holder% of sharesSharesValueChangeReported
1Vanguard MStar Total Stk Mkt Idx Invest0.58%615K$3.7M—August 31, 2026
2iShares Russell 2000 ETF0.37%396K$2.4M−4,544 (−1.1%)September 30, 2026
3Fidelity Small Cap Index0.19%200K$1.2M−246 (−0.1%)July 31, 2026
4Schwab US Small-Cap ETF™0.17%185K$1.1M+117 (+0.1%)September 30, 2026
5Fidelity Extended Market Index0.10%110K$670,496−593 (−0.5%)August 31, 2026
6Vanguard Russell 2000 ETF0.10%106K$643,015+2,040 (+2.0%)August 31, 2026
7iShares Russell 2000 Growth ETF0.09%101K$611,630−127 (−0.1%)September 30, 2026
8Fidelity Nasdaq Composite Index0.06%62K$378,231—August 31, 2026
9Schwab Small Cap Index0.04%45K$272,852—August 31, 2026
10Multimanager Aggressive Equity IA0.04%43K$262,656—August 31, 2026
11iShares Russell 2000 Value ETF0.04%42K$254,691+64 (+0.2%)September 30, 2026
12iShares Russell 2000 Small-Cap Idx Instl0.04%42K$253,025—August 31, 2026
13Fidelity Total Market Index0.04%37K$227,872—August 31, 2026
14Fidelity Series Total Market Index0.03%32K$194,274—August 31, 2026
15Nuveen Small Cap Blend Idx R60.02%25K$148,990—August 31, 2026
16Goldman Sachs Absolute Ret Trckr Instl0.02%23K$138,217+15,253 (+203.9%)June 30, 2026
17Schwab Total Stock Market Index0.02%21K$127,583—August 31, 2026
18WisdomTree US SmallCap Earnings ETF0.02%19K$118,189—September 30, 2026

Funds report holdings monthly or quarterly; dates differ by fund.

GYRE insider transactions

latest 2
Gyre Therapeutics, Inc. insider transactions
DateNameTransactionPriceSharesValue
2025-05-23Songjiang MaSell$10.24182$1,864
2025-05-22Songjiang MaSell$10.972,000$21,940

Reported trades by company officers, directors and other filers (including disclosures by members of Congress where EODHD lists them). "—" where the filing gives no share count.

GYRE shares outstanding

Shares outstanding

Year-end shares outstanding, adjusted for splits.

Who owns GYRE

Institutional investors own 8.2% of Gyre Therapeutics's shares and insiders 74.40%. The largest holder is HSG Holding Ltd with 3.54% of the shares (3.8M), as of June 30, 2026. Among the top 20 institutions, 16 added shares and 3 reduced their stake in the latest filings. Short interest is 6.45% of the float, or 10.40 days of average trading volume. The share count rose 31,889.1% since 2014.

Related: GYRE analyst forecast, GYRE key metrics. See the GYRE stock overview for the latest quote and news.

GYRE ownership FAQ

Who owns the most Gyre Therapeutics stock?

The largest shareholders of Gyre Therapeutics are HSG Holding Ltd (3.54%), BlackRock Inc (0.94%), Octagon Capital Advisors LP (0.90%), Vanguard Capital Management, LLC (0.83%), Geode Capital Management, LLC (0.50%).

What percentage of Gyre Therapeutics is owned by institutions?

Institutions hold 8.2% of Gyre Therapeutics's shares outstanding; insiders hold 74.40%.

Which funds own Gyre Therapeutics?

The largest fund holders of Gyre Therapeutics are Vanguard MStar Total Stk Mkt Idx Invest (0.58%), iShares Russell 2000 ETF (0.37%), Fidelity Small Cap Index (0.19%), Schwab US Small-Cap ETF™ (0.17%), Fidelity Extended Market Index (0.10%).

What is Gyre Therapeutics's short interest?

1.9M shares of Gyre Therapeutics were sold short, 6.45% of the float; at the average daily volume it would take 10.40 days to cover.

Are insiders buying or selling Gyre Therapeutics?

Of the latest 2 reported insider transactions in Gyre Therapeutics (since May 22, 2025), 0 were purchases and 2 were sales.

How many shares of Gyre Therapeutics are outstanding?

Gyre Therapeutics has 106.0M shares outstanding, of which 35.9M are in the public float.

Biotechnology: ownership