Structure Therapeutics Inc. (GPCR) Ownership
GPCR ownership summary
as of October 17, 2026- Institutions
- 97.6% of shares outstanding
- Insiders
- 3.11% of shares outstanding
- Shares outstanding
- 71.3M
- Float
- 55.5M shares available to trade
- Short interest
- 14.48% 7.5M shares short
- Days to cover
- 5.44 short interest up 14.2% vs prior month
- Institutions 97.59%
- Insiders 3.11%
GPCR top institutional holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | FMR Inc | 10.95% | 7.8M | $164.6M | −593,143 (−7.1%) | June 30, 2026 |
| 2 | Wellington Management Company LLP | 10.35% | 7.4M | $155.6M | +119,146 (+1.6%) | June 30, 2026 |
| 3 | venBio Select Advisor LLC | 9.19% | 6.6M | $138.2M | — | June 30, 2026 |
| 4 | HHG PLC | 7.51% | 5.4M | $112.9M | +264,833 (+5.2%) | March 31, 2026 |
| 5 | Jupiter Topco LLC | 7.30% | 5.2M | $109.7M | +5.2M (0.0%) | June 30, 2026 |
| 6 | Deep Track Capital, LP | 6.65% | 4.7M | $99.9M | +460,224 (+10.8%) | June 30, 2026 |
| 7 | Bvf Inc | 4.72% | 3.4M | $71.0M | −92,535 (−2.7%) | June 30, 2026 |
| 8 | Morgan Stanley - Brokerage Accounts | 3.94% | 2.8M | $59.2M | +501,183 (+21.7%) | June 30, 2026 |
| 9 | Orbimed Advisors LLC | 3.10% | 2.2M | $46.6M | +733,997 (+49.7%) | June 30, 2026 |
| 10 | Principal Financial Group Inc | 2.46% | 1.8M | $36.9M | −1,011 (−0.1%) | June 30, 2026 |
| 11 | American Century Companies Inc | 2.36% | 1.7M | $35.5M | +244,148 (+17.0%) | June 30, 2026 |
| 12 | RTW INVESTMENTS, LLC | 2.25% | 1.6M | $33.9M | +1.6M (0.0%) | June 30, 2026 |
| 13 | Driehaus Capital Management LLC | 2.18% | 1.6M | $32.7M | −24,137 (−1.5%) | June 30, 2026 |
| 14 | Baker Bros Advisors LP | 2.01% | 1.4M | $30.2M | — | June 30, 2026 |
| 15 | Casdin Capital, LLC | 1.65% | 1.2M | $24.8M | — | June 30, 2026 |
| 16 | Deerfield Management Co | 1.52% | 1.1M | $22.9M | +318,007 (+41.4%) | June 30, 2026 |
| 17 | Capitolis Liquid Global Markets LLC | 1.46% | 1.0M | $21.9M | −110,200 (−9.6%) | June 30, 2026 |
| 18 | Siren, L.L.C. | 1.22% | 873K | $18.4M | −455,731 (−34.3%) | June 30, 2026 |
| 19 | T. Rowe Price Associates, Inc. | 1.19% | 846K | $17.8M | −1.2M (−57.7%) | June 30, 2026 |
| 20 | Pacific Heights Asset Management, LLC | 1.12% | 800K | $16.9M | +50,000 (+6.7%) | June 30, 2026 |
Value at the latest close. Change = shares bought or sold in the latest quarterly filing (13F). In the top 20, 10 holders added 9.5M shares and 7 cut 2.4M.
GPCR top mutual fund and ETF holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Inv | 4.08% | 2.9M | $61.3M | — | June 30, 2026 |
| 2 | Worldwide Healthcare Ord | 1.84% | 1.3M | $27.7M | +389,400 (+42.2%) | June 30, 2026 |
| 3 | American Century Heritage Inv | 1.36% | 967K | $20.4M | +199,679 (+26.0%) | June 30, 2026 |
| 4 | Xtrackers MSCI USA Swap ETF 1C | 1.17% | 837K | $17.6M | +837,226 (0.0%) | December 31, 2025 |
| 5 | Fidelity Advisor Growth Opps M | 1.03% | 734K | $15.5M | — | August 31, 2026 |
| 6 | Principal Glb Emerging Markets R5 | 0.88% | 626K | $13.2M | — | August 31, 2026 |
| 7 | Fidelity VIP Contrafund Initial | 0.83% | 595K | $12.5M | +300,344 (+101.9%) | August 31, 2026 |
| 8 | Janus Henderson Hrzn Biotec E2 USD | 0.82% | 581K | $12.3M | +16,041 (+2.8%) | June 30, 2026 |
| 9 | Janus Henderson Global Life Sciences D | 0.79% | 561K | $11.8M | +11,880 (+2.2%) | August 31, 2026 |
| 10 | Fidelity Select Biotechnology | 0.76% | 542K | $11.4M | — | August 31, 2026 |
| 11 | Janus Henderson Glb Life Scn I2 USD | 0.76% | 540K | $11.4M | +6,130 (+1.1%) | August 31, 2026 |
| 12 | Fidelity Advisor New Insights I | 0.76% | 540K | $11.4M | +169,392 (+45.8%) | August 31, 2026 |
| 13 | Janus Global Life Science AUSD | 0.75% | 534K | $11.2M | +7,129 (+1.4%) | June 30, 2026 |
| 14 | Fidelity Advisor Biotechnology I | 0.74% | 528K | $11.1M | — | August 31, 2026 |
| 15 | Fidelity Select Health Care | 0.70% | 500K | $10.5M | — | August 31, 2026 |
| 16 | iShares Biotechnology ETF | 0.68% | 481K | $10.1M | −3,648 (−0.8%) | September 30, 2026 |
| 17 | Janus Henderson Triton D | 0.66% | 467K | $9.8M | — | August 31, 2026 |
| 18 | Fidelity Stock Selector Small Cap | 0.61% | 433K | $9.1M | — | July 31, 2026 |
| 19 | Fidelity Small Cap Growth | 0.58% | 414K | $8.7M | — | July 31, 2026 |
| 20 | Vanguard Explorer Inv | 0.57% | 406K | $8.6M | −171,617 (−29.7%) | June 30, 2026 |
Funds report holdings monthly or quarterly; dates differ by fund.
GPCR shares outstanding
Year-end shares outstanding, adjusted for splits.
Who owns GPCR
Institutional investors own 97.6% of Structure Therapeutics's shares and insiders 3.11%. The largest holder is FMR Inc with 10.95% of the shares (7.8M), as of June 30, 2026. Among the top 20 institutions, 10 added shares and 7 reduced their stake in the latest filings. Short interest is 14.48% of the float, or 5.44 days of average trading volume. The share count rose 61.8% since 2021.
Related: GPCR analyst forecast, GPCR key metrics. See the GPCR stock overview for the latest quote and news.
GPCR ownership FAQ
Who owns the most Structure Therapeutics stock?
The largest shareholders of Structure Therapeutics are FMR Inc (10.95%), Wellington Management Company LLP (10.35%), venBio Select Advisor LLC (9.19%), HHG PLC (7.51%), Jupiter Topco LLC (7.30%).
What percentage of Structure Therapeutics is owned by institutions?
Institutions hold 97.6% of Structure Therapeutics's shares outstanding; insiders hold 3.11%.
Which funds own Structure Therapeutics?
The largest fund holders of Structure Therapeutics are Vanguard Health Care Inv (4.08%), Worldwide Healthcare Ord (1.84%), American Century Heritage Inv (1.36%), Xtrackers MSCI USA Swap ETF 1C (1.17%), Fidelity Advisor Growth Opps M (1.03%).
What is Structure Therapeutics's short interest?
7.5M shares of Structure Therapeutics were sold short, 14.48% of the float; at the average daily volume it would take 5.44 days to cover.
How many shares of Structure Therapeutics are outstanding?
Structure Therapeutics has 71.3M shares outstanding, of which 55.5M are in the public float.