Spyre Therapeutics, Inc. (SYRE) Stock Chart
SYRE price chart
Daily prices adjusted for splits and dividends. 1D and 5D show delayed intraday prices. Markers: E earnings, D dividend, S split.
Technical snapshot
Key levels & statistics
SYRE performance vs the market
Total return, dividends reinvestedSYRE monthly returns
SYRE historical prices
SYRE dividends & splits
About the SYRE chart
Spyre Therapeutics (SYRE) closed at $79.90 on October 16, 2026, up 143.9% so far this year. The stock is trading 14.0% above its 200-day moving average of $70.09, which technical analysts usually read as a long-term uptrend. Over the past year SYRE returned +259.3% including dividends, ahead of the S&P 500 (+16.8%).
This page charts the full trading history of Spyre Therapeutics, Inc. stock. Daily prices come from EODHD and are adjusted for stock splits and dividends, so returns over long periods are comparable. For the latest quote, company profile, earnings and news, see the SYRE stock overview.
SYRE chart FAQ
What is Spyre Therapeutics's all-time high stock price?
The highest closing price for SYRE was $299.75 on April 8, 2016 (adjusted for stock splits). As of the October 16, 2026 close it traded 73.3% below that level.
What is the 52-week range of SYRE stock?
Over the 52 weeks to October 16, 2026, SYRE traded between an intraday low of $21.14 on November 7, 2025 and an intraday high of $110.17 on August 19, 2026.
Is SYRE above its 200-day moving average?
Yes. On October 16, 2026 SYRE closed at $79.90, 14.0% above its 200-day simple moving average of $70.09. The 50-day average was $92.31.
How has SYRE stock performed compared with the S&P 500?
Including reinvested dividends, SYRE returned +259.3% over the past year, compared with +16.8% for the S&P 500 (SPY). Over five years the figures were −60.9% and +83.0%.
Does Spyre Therapeutics pay a dividend?
Spyre Therapeutics has not paid a dividend in the past 12 months.
Has SYRE stock ever split?
SYRE has split its stock 1 time: 1:25 (September 8, 2023). Prices on this chart are adjusted for all splits.
How do I read the SYRE chart?
Pick a time range above the chart and choose candlesticks, a line or an area chart. Moving averages, Bollinger Bands, volume, RSI and MACD can be switched on with the indicator buttons, and "Compare" plots SYRE against the S&P 500, its sector or a competitor as a percentage change. Chart prices are adjusted for splits and dividends.