Spyre Therapeutics, Inc. (SYRE) Cash Flow Statement
Where SYRE’s cash came from and went, 2025
December 31, 2025 · U.S. dollars- Cash from operations
- −$169.3M
- Capital expenditures
- $0
- Free cash flow
- −$169.3M
- Returned to shareholders
- —
- Change in cash
- −$3.7M cash at year-end $85.7M
Cash from operations
−$169.3M
Investments (net)
−$150.5M
Acquisitions & other
+$7.0M
Shares issued
+$311.1M
Other financing
−$2.1M
Change in cash
−$3.7M
Drawn to scale: where the cash came from and how it was used. Hover for values.
SYRE operating cash flow, capex and free cash flow
Operating cash flowCapital expendituresFree cash flowFCF margin (right axis)
SYRE cash flow trends, 2016–2025
| Metric | Trend | Then | Latest | Change |
|---|---|---|---|---|
| Operating cash flow | −$18.8M2016 | −$169.3M2025 | — | |
| Capital expenditures | $212,0002016 | $02025 | −100.0% | |
| Free cash flow | −$19.1M2016 | −$169.3M2025 | — | |
| Free cash flow margin | −411.7%2016 | −17,766.4%2024 | −17,354.7 pts | |
| Stock-based compensation | $5.5M2019 | $37.6M2025 | +37.8%/yr | |
| Capex / revenue | 4.6%2016 | 0.0%2024 | −4.6 pts |
Change is the average annual growth (CAGR) or the difference between the first and latest year.
SYRE cash flow by activity
OperatingInvestingFinancingChange in cash
SYRE net income vs operating cash flow
Net incomeOperating cash flow
Operating cash flow above net income usually means earnings are backed by cash (depreciation and stock-based pay are non-cash expenses).
SYRE cash flow statement
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Operating activities | ||||||||||
| Net income | −$155.2M | −$208.0M | −$338.8M | −$83.8M | −$65.8M | −$80.9M | −$78.3M | −$44.3M | −$27.2M | −$21.7M |
| Depreciation & amortization | $10.0M | $744,000 | $744,000 | $2.0M | $1.6M | $996,000 | $901,000 | $293,000 | $249,000 | $132,000 |
| Stock-based compensation | $37.6M | $44.8M | $25.7M | $7.1M | $8.0M | $6.3M | $5.5M | — | — | — |
| Change in working capital | −$5.9M | −$4.5M | −$5.2M | −$5.5M | $1.8M | −$2.5M | $7.1M | $7.2M | −$198,000 | $1.4M |
| Other non-cash items | −$55.7M | $9.6M | $217.7M | $99,000 | $638,000 | $406,000 | −$941,000 | $4.7M | $2.6M | $1.3M |
| Cash from operating activities | −$169.3M | −$157.4M | −$99.9M | −$80.1M | −$53.7M | −$75.8M | −$65.7M | −$32.2M | −$24.6M | −$18.8M |
| Investing activities | ||||||||||
| Capital expenditures | $0 | $0 | $0 | −$38,000 | −$573,000 | −$4.3M | −$1.5M | −$422,000 | −$619,000 | −$212,000 |
| Investments (net) | −$150.5M | −$353.3M | −$108.4M | $57.0M | −$22.6M | −$7.6M | −$15.7M | — | — | — |
| Acquisitions & other investing | $7.0M | $0 | — | $38,000 | $573,000 | $4.3M | $15.4M | −$14.8M | −$21.9M | −$11.9M |
| Cash from investing activities | −$143.5M | −$353.3M | — | $57.0M | −$22.6M | −$7.6M | −$1.7M | −$15.2M | −$22.5M | −$12.2M |
| Financing activities | ||||||||||
| Net borrowing (repayment) | — | $0 | −$16,000 | −$418,000 | −$510,000 | — | — | — | — | — |
| Shares issued | $311.1M | $405.2M | $366.5M | $42.9M | $0 | $153.7M | $129.2M | $0 | $0 | $0 |
| Other financing | −$2.1M | $5.7M | −$5.4M | $222,000 | $1.9M | $796,000 | −$63.5M | $57.1M | $12.2M | $49.4M |
| Cash from financing activities | $309.0M | $410.9M | $361.1M | $42.7M | $1.4M | $154.5M | $65.7M | $57.1M | $12.2M | $49.4M |
| Summary | ||||||||||
| Net change in cash | −$3.7M | −$99.8M | $152.8M | $19.4M | −$75.0M | $71.2M | −$3.2M | $9.6M | −$34.9M | $18.4M |
| Cash at end of period | $85.7M | $89.4M | $189.2M | $36.4M | $17.0M | $91.9M | $19.3M | $22.5M | $12.8M | $47.7M |
| Free cash flow | −$169.3M | −$157.4M | −$99.9M | −$80.2M | −$54.3M | −$80.1M | −$67.2M | −$32.6M | −$25.2M | −$19.1M |
| Free cash flow margin | — | −17,766.4% | −11,276.5% | −3,442.8% | −289.7% | — | — | −838.9% | −484.8% | −411.7% |
| Capex / revenue | — | 0.0% | 0.0% | 1.6% | 3.1% | — | — | 10.9% | 11.9% | 4.6% |
| Jun '26 | Mar '26 | Dec '25 | Sep '25 | Jun '25 | Mar '25 | Dec '24 | Sep '24 | Jun '24 | Mar '24 | Dec '23 | Sep '23 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating activities | ||||||||||||
| Net income | −$36.2M | −$69.0M | −$62.5M | −$11.2M | −$36.7M | −$44.8M | −$56.3M | −$69.0M | −$38.8M | −$43.9M | −$63.2M | −$40.1M |
| Depreciation & amortization | — | — | −$8.1M | — | — | — | −$11.4M | $0 | $0 | $0 | −$220,000 | $0 |
| Stock-based compensation | $13.5M | $12.8M | $9.8M | $9.6M | $9.4M | $8.9M | $9.2M | $13.1M | $8.7M | $13.8M | $17.3M | $4.8M |
| Change in working capital | −$8.9M | $244,000 | −$2.3M | $5.9M | −$9.0M | −$568,000 | $10.8M | $10.4M | −$29.2M | $3.5M | −$1.9M | −$8.0M |
| Other non-cash items | −$38.3M | −$1.4M | $18.5M | −$41.4M | −$10.2M | −$4.5M | $10.5M | $16.2M | −$2.9M | −$2.0M | $17.0M | $8.7M |
| Cash from operating activities | −$69.9M | −$57.4M | −$44.6M | −$37.1M | −$46.6M | −$41.0M | −$37.2M | −$29.4M | −$62.2M | −$28.5M | −$31.0M | −$34.6M |
| Investing activities | ||||||||||||
| Capital expenditures | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Investments (net) | −$337.9M | $26.6M | −$247.4M | $25.0M | $79.0M | −$61,000 | −$170.5M | $42.7M | −$120.5M | −$105.0M | −$35.3M | −$97.6M |
| Acquisitions & other investing | $40.0M | $30.0M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Cash from investing activities | −$297.9M | $56.6M | −$247.4M | $25.0M | $79.0M | −$61,000 | −$170.5M | $42.7M | −$120.5M | −$105.0M | −$35.3M | −$97.6M |
| Financing activities | ||||||||||||
| Share repurchases & issuance (net) | — | — | $117,000 | — | $0 | −$117,000 | — | — | $0 | $0 | — | — |
| Net borrowing (repayment) | — | — | — | — | — | — | $0 | $0 | — | — | — | — |
| Shares issued | $435.2M | $9.8M | $311.1M | $0 | $0 | $0 | $224.6M | $11.5M | $0 | $169.2M | $169.1M | $0 |
| Other financing | −$2.6M | $2.5M | $1.6M | −$4.6M | $731,000 | $242,000 | $979,000 | $1.2M | $360,000 | $3.0M | −$5.5M | −$12.5M |
| Cash from financing activities | $432.6M | $12.3M | $312.8M | −$4.6M | $731,000 | $125,000 | $225.6M | $12.8M | $360,000 | $172.2M | $163.6M | −$12.5M |
| Summary | ||||||||||||
| Net change in cash | $64.8M | $11.5M | $20.8M | −$16.8M | $33.2M | −$40.9M | $17.8M | $26.1M | −$182.4M | $38.7M | $97.3M | −$144.8M |
| Cash at end of period | $162.0M | $97.2M | $85.7M | $64.9M | $81.7M | $48.5M | $89.4M | $71.6M | $45.1M | $227.9M | $189.2M | $91.9M |
| Free cash flow | −$69.9M | −$57.4M | −$44.6M | −$37.1M | −$46.6M | −$41.0M | −$37.2M | −$29.4M | −$62.2M | −$28.5M | −$31.0M | −$34.6M |
| Free cash flow margin | — | — | −49.3% | — | — | — | — | — | — | — | −2,978.5% | — |
| Capex / revenue | — | — | 0.0% | — | — | — | — | — | — | — | 0.0% | — |
Negative numbers are cash paid out. Quarterly columns are labeled by the month the quarter ended. Figures in U.S. dollars as reported; data from EODHD.
SYRE cash generation
In fiscal 2025 (ended December 31, 2025), Spyre Therapeutics generated -$169.3 million of cash from operations and spent $0 on capital expenditures, leaving free cash flow of -$169.3 million. Cash and equivalents fell by $3.7 million over the year.
Related: SYRE income statement, SYRE balance sheet. See the SYRE stock overview for the latest quote and news.
SYRE cash flow FAQ
What is Spyre Therapeutics's free cash flow?
Spyre Therapeutics's free cash flow was -$169.3 million in fiscal 2025: -$169.3 million of operating cash flow minus $0 of capital expenditures It was -$157.4 million a year earlier..
How much cash does Spyre Therapeutics generate from operations?
Spyre Therapeutics generated -$169.3 million of cash from operating activities in fiscal 2025.