Schrödinger, Inc. (SDGR) AI Stock Analysis

NASDAQ: SDGRAI research summary: business, growth, valuation, analysts, bull and bear case.

SDGR AI stock analysis summary

AI Research

Schrödinger, Inc. (SDGR) develops physics-based software tools for molecular discovery across drug development and materials science. Revenue grew 23.3% in FY2025 to $255.9M, helping the company achieve positive free cash flow of $12.5M. However, profitability remains negative, reflected in an operating margin of -70.5% over the trailing twelve months.

Market cap
$1.69B
Revenue (TTM)
$259.0M
P/E
—
1Y return
11.3%
S&P 500 16.8%
Avg. target
$25.57
13.1% vs last close

Bull case

  • Annual revenue rebounded with 23.3% growth in FY2025 to reach $255.9M.
  • The balance sheet is well-capitalized with $305.8M in net cash and a current ratio of 2.71 as of June 30, 2026.
  • Free cash flow turned positive in FY2025 at $12.5M after several years of cash burn.

Bear case

  • Operating margin over the trailing twelve months remains negative at -70.5% with diluted EPS of -$0.74.
  • Consensus estimates project FY2026 revenue of $241.5M, which represents a drop from $255.9M generated in FY2025.
  • The stock recorded a 5-year return of -59.2%, significantly lagging the S&P 500 return of 83.0% over the same timeframe.

What Schrödinger does

Schrödinger, Inc. provides a physics-based computational software platform for novel molecule discovery in drug development and materials science. Established in 1990 and headquartered in New York, the company operates across two segments: Software and Drug Discovery. The Software segment licenses computational tools to support molecular simulation and discovery across life sciences and materials science. The Drug Discovery segment develops an internal and collaborative portfolio of preclinical and clinical therapeutic candidates. Its customer base includes biopharmaceutical firms, industrial companies, academic institutions, and government laboratories across the world.

Growth and profitability

Revenue increased from $137.9M in FY2021 to $255.9M in FY2025, representing a 5-year revenue CAGR of 18.8%. Annual revenue grew 23.3% in FY2025 after a decline of 4.2% in FY2024. Gross margin stood at 55.7% in FY2025, while operating margin was -65.2% and net income was -$103.3M. R&D expenses were $173.1M in FY2025, down from $201.8M in FY2024. For the trailing twelve months ending June 30, 2026, revenue reached $259.0M with an operating margin of -70.5% and diluted EPS of -$0.74. In the latest quarter ending June 30, 2026, quarterly revenue grew 7.5% year-over-year.

SDGR income statement →

Balance sheet and cash flow

As of June 30, 2026, Schrödinger held $413.7M in cash and short-term investments and $108.0M in total debt, resulting in net cash of $305.8M. Total assets stood at $640.4M against shareholders' equity of $329.0M, supporting a current ratio of 2.71 and a debt-to-equity ratio of 0.33. Operating cash flow improved to $13.9M in FY2025, while free cash flow reached $12.5M alongside $1.4M in capital expenditures. Share count increased 7.0% over five years.

SDGR balance sheet →

Valuation and performance

At a last close of $22.60 on October 16, 2026, Schrödinger trades at an enterprise value of $1.88B and a price-to-sales multiple of 6.5x, above the 4.1x median of its US-listed Healthcare peers. Its enterprise value-to-revenue multiple is 7.3x, and price-to-book is 6.6x. The stock returned 11.3% over the past year and -59.2% over five years, trailing the S&P 500 (SPY) returns of 16.8% and 83.0% over those respective periods. Shares trade 37.8% above their 200-day moving average with a beta of 1.62.

SDGR key metrics →

What analysts expect

Wall Street analysts hold 5 Strong Buy and 2 Hold ratings on Schrödinger. The mean price target is $25.57, representing a 13.1% premium to the last close of $22.60. For the fiscal year ending December 31, 2026, consensus estimates project revenue of $241.5M and an EPS of -$1.64. For the following fiscal year, 5 analysts expect revenue of $248.9M and an EPS of -$1.38. Schrödinger beat EPS estimates in 3 of the last 4 quarters, with next earnings scheduled for November 4, 2026.

SDGR forecast and price target →

Key risks and what to watch

  • Short interest represents a significant portion of trading activity, with short percent of float at 24.1%.
  • High market volatility is present, as evidenced by a beta of 1.62.
  • Research and development expenses totaled $173.1M in FY2025, presenting sustained margin pressure if revenue expansion slows.

AI-generated research summary. Written with AI from Quotelinks data as of October 16, 2026 and checked so every figure matches that data. For information only, not investment advice. Disclaimer

About this SDGR AI stock analysis

This page is an AI-written research summary of Schrödinger, Inc. (SDGR). The text was generated on October 30, 2026 from Quotelinks data as of October 16, 2026 (company profile, annual results, latest balance sheet, valuation, price performance and analyst estimates). An automatic check rejects any draft that contains a figure not found in that data. It is not investment advice; verify figures on the linked tabs before making decisions.

Related: SDGR income statement, SDGR balance sheet, SDGR key metrics, SDGR analyst forecast, SDGR chart. See the SDGR stock overview for the latest quote and news.

SDGR AI stock analysis FAQ

What does Schrödinger, Inc. do?

Schrödinger develops a physics-based computational software platform used to discover novel molecules for drug development and materials applications. It earns revenue through software licensing and collaborative or internal drug discovery programs.

Does Schrödinger pay a dividend?

No, Schrödinger does not pay a dividend.

What are analysts' price targets for SDGR stock?

Analysts have a mean price target of $25.57 for SDGR, which is 13.1% above its last close price of $22.60 on October 16, 2026.

When is Schrödinger's next earnings report date?

Schrödinger is scheduled to report its next quarterly earnings on November 4, 2026.

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