OPKO Health, Inc. (OPK) Ownership
OPK ownership summary
as of October 18, 2026- Institutions
- 27.6% of shares outstanding
- Insiders
- 50.52% of shares outstanding
- Shares outstanding
- 746.3M
- Float
- 323.7M shares available to trade
- Short interest
- 8.57% 35.6M shares short
- Days to cover
- 12.42 short interest down 1.2% vs prior month
- Institutions 27.56%
- Insiders 50.52%
- Other investors 21.92%
OPK top institutional holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | Rubric Capital Management LP | 6.40% | 47.8M | $73.1M | — | June 30, 2026 |
| 2 | BlackRock Inc | 4.95% | 37.0M | $56.6M | +746,670 (+2.1%) | June 30, 2026 |
| 3 | Vanguard Capital Management, LLC | 2.01% | 15.0M | $22.9M | +469,766 (+3.2%) | June 30, 2026 |
| 4 | Vanguard Portfolio Management, LLC | 2.00% | 14.9M | $22.9M | +165,205 (+1.1%) | June 30, 2026 |
| 5 | Geode Capital Management, LLC | 1.55% | 11.6M | $17.7M | +279,526 (+2.5%) | June 30, 2026 |
| 6 | State Street Corp | 1.38% | 10.3M | $15.8M | +807,693 (+8.5%) | June 30, 2026 |
| 7 | The Goldman Sachs Group Inc | 0.94% | 7.0M | $10.8M | −639,534 (−8.3%) | June 30, 2026 |
| 8 | UBS Group AG | 0.67% | 5.0M | $7.7M | −1.1M (−17.5%) | June 30, 2026 |
| 9 | Whitefort Capital Management, LP. | 0.60% | 4.5M | $6.9M | +258,072 (+6.1%) | June 30, 2026 |
| 10 | Northern Trust Corp | 0.50% | 3.8M | $5.7M | +136,817 (+3.8%) | June 30, 2026 |
| 11 | Charles Schwab Investment Management Inc | 0.48% | 3.6M | $5.5M | +22,941 (+0.6%) | June 30, 2026 |
| 12 | Highbridge Capital Management, LLC | 0.48% | 3.6M | $5.5M | +3.6M (0.0%) | June 30, 2026 |
| 13 | Vanguard Fiduciary Trust Co | 0.36% | 2.7M | $4.1M | −35,782 (−1.3%) | June 30, 2026 |
| 14 | Awm Investment Company Inc | 0.28% | 2.1M | $3.2M | +10,000 (+0.5%) | June 30, 2026 |
| 15 | Morgan Stanley - Brokerage Accounts | 0.26% | 2.0M | $3.0M | +778,940 (+65.1%) | June 30, 2026 |
| 16 | Citadel Advisors Llc | 0.19% | 1.4M | $2.2M | −658,625 (−31.7%) | June 30, 2026 |
| 17 | WASHINGTON GROWTH STRATEGIES LLC | 0.18% | 1.4M | $2.1M | — | June 30, 2026 |
| 18 | Bank of New York Mellon Corp | 0.18% | 1.3M | $2.0M | +49,932 (+3.9%) | June 30, 2026 |
| 19 | Dimensional Fund Advisors, Inc. | 0.17% | 1.3M | $1.9M | −292,259 (−18.7%) | June 30, 2026 |
| 20 | Y.D. More Investments Ltd | 0.17% | 1.3M | $1.9M | −41,905 (−3.2%) | June 30, 2026 |
Value at the latest close. Change = shares bought or sold in the latest quarterly filing (13F). In the top 20, 12 holders added 7.3M shares and 6 cut 2.7M.
OPK top mutual fund and ETF holders
20 largest| # | Holder | % of shares | Shares | Value | Change | Reported |
|---|---|---|---|---|---|---|
| 1 | iShares Russell 2000 ETF | 1.38% | 10.3M | $15.8M | −118,912 (−1.1%) | September 30, 2026 |
| 2 | Vanguard MStar Total Stk Mkt Idx Invest | 1.31% | 9.8M | $14.9M | — | August 31, 2026 |
| 3 | Vanguard Small Cap Index | 0.93% | 6.9M | $10.6M | +4,642 (+0.1%) | August 31, 2026 |
| 4 | Fidelity Small Cap Index | 0.58% | 4.4M | $6.7M | −5,363 (−0.1%) | July 31, 2026 |
| 5 | iShares Russell 2000 Value ETF | 0.50% | 3.7M | $5.7M | +5,666 (+0.2%) | September 30, 2026 |
| 6 | iShares Biotechnology ETF | 0.38% | 2.8M | $4.3M | −21,512 (−0.8%) | September 30, 2026 |
| 7 | Vanguard Russell 2000 ETF | 0.31% | 2.3M | $3.5M | +60,217 (+2.7%) | August 31, 2026 |
| 8 | Schwab US Small-Cap ETF™ | 0.30% | 2.2M | $3.4M | +1,494 (+0.1%) | September 30, 2026 |
| 9 | Vanguard MStar Small Cap Value Index | 0.30% | 2.2M | $3.4M | +5,460 (+0.2%) | August 31, 2026 |
| 10 | Goldman Sachs Small Cp Val Insghts Instl | 0.27% | 2.0M | $3.1M | — | July 31, 2026 |
| 11 | Vanguard MStar Small Cap Growth Indx Inv | 0.27% | 2.0M | $3.0M | −8,580 (−0.4%) | August 31, 2026 |
| 12 | Fidelity Extended Market Index | 0.24% | 1.8M | $2.8M | −9,768 (−0.5%) | August 31, 2026 |
| 13 | Vanguard Health Care ETF | 0.16% | 1.2M | $1.8M | +5,040 (+0.4%) | August 31, 2026 |
| 14 | Schwab Small Cap Index | 0.13% | 984K | $1.5M | — | August 31, 2026 |
| 15 | Fidelity Total Market Index | 0.12% | 884K | $1.4M | — | August 31, 2026 |
| 16 | Stt Strt SPDR® Russell2000 US SmCapETF | 0.12% | 867K | $1.3M | +41,492 (+5.0%) | August 31, 2026 |
| 17 | iShares Russell 2000 Small-Cap Idx Instl | 0.10% | 778K | $1.2M | — | August 31, 2026 |
| 18 | Stt Strt® SPDR® S&P®HlthCrSvcsETF | 0.10% | 778K | $1.2M | −23,555 (−2.9%) | September 30, 2026 |
| 19 | iShares US Healthcare Providers ETF | 0.10% | 771K | $1.2M | +4,683 (+0.6%) | September 30, 2026 |
| 20 | iShares Core S&P Total US Stock Mkt ETF | 0.10% | 751K | $1.1M | +650 (+0.1%) | September 30, 2026 |
Funds report holdings monthly or quarterly; dates differ by fund.
OPK insider transactions
latest 6| Date | Name | Transaction | Price | Shares | Value |
|---|---|---|---|---|---|
| 2026-03-20 | John A Paganelli | Buy | $1.14 | 10,000 | $11,400 |
| 2025-11-21 | Phillip Md Et Al Frost | Buy | $1.33 | 580,000 | $771,400 |
| 2025-11-19 | Phillip Md Et Al Frost | Buy | $1.31 | 580,000 | $759,800 |
| 2025-11-18 | Phillip Md Et Al Frost | Buy | $1.27 | 533,300 | $677,291 |
| 2025-10-31 | Phillip Md Et Al Frost | Buy | $1.42 | 150,000 | $213,000 |
| 2025-08-08 | Phillip Md Et Al Frost | Buy | $1.32 | 675,000 | $891,000 |
Reported trades by company officers, directors and other filers (including disclosures by members of Congress where EODHD lists them). "—" where the filing gives no share count.
OPK shares outstanding
Year-end shares outstanding, adjusted for splits.
Who owns OPK
Institutional investors own 27.6% of OPKO Health's shares and insiders 50.52%. The largest holder is Rubric Capital Management LP with 6.40% of the shares (47.8M), as of June 30, 2026. Among the top 20 institutions, 12 added shares and 6 reduced their stake in the latest filings. Short interest is 8.57% of the float, or 12.42 days of average trading volume. The share count rose 73.3% since 2014.
Related: OPK analyst forecast, OPK key metrics. See the OPK stock overview for the latest quote and news.
OPK ownership FAQ
Who owns the most OPKO Health stock?
The largest shareholders of OPKO Health are Rubric Capital Management LP (6.40%), BlackRock Inc (4.95%), Vanguard Capital Management, LLC (2.01%), Vanguard Portfolio Management, LLC (2.00%), Geode Capital Management, LLC (1.55%).
What percentage of OPKO Health is owned by institutions?
Institutions hold 27.6% of OPKO Health's shares outstanding; insiders hold 50.52%.
Which funds own OPKO Health?
The largest fund holders of OPKO Health are iShares Russell 2000 ETF (1.38%), Vanguard MStar Total Stk Mkt Idx Invest (1.31%), Vanguard Small Cap Index (0.93%), Fidelity Small Cap Index (0.58%), iShares Russell 2000 Value ETF (0.50%).
What is OPKO Health's short interest?
35.6M shares of OPKO Health were sold short, 8.57% of the float; at the average daily volume it would take 12.42 days to cover.
Are insiders buying or selling OPKO Health?
Of the latest 6 reported insider transactions in OPKO Health (since August 8, 2025), 6 were purchases and 0 were sales.
How many shares of OPKO Health are outstanding?
OPKO Health has 746.3M shares outstanding, of which 323.7M are in the public float.