OPKO Health, Inc. (OPK) Cash Flow Statement
Where OPK’s cash came from and went, 2025
December 31, 2025 · U.S. dollars- Cash from operations
- −$178.5M
- Capital expenditures
- $12.3M 2.0% of revenue
- Free cash flow
- −$190.8M −31.4% margin
- Returned to shareholders
- $47.0M
- Change in cash
- −$62.9M cash at year-end $382.7M
Drawn to scale: where the cash came from and how it was used. Hover for values.
OPK operating cash flow, capex and free cash flow
OPK cash flow trends, 2016–2025
| Metric | Trend | Then | Latest | Change |
|---|---|---|---|---|
| Operating cash flow | $32.0M2016 | −$178.5M2025 | — | |
| Capital expenditures | $23.5M2016 | $12.3M2025 | −7.0%/yr | |
| Free cash flow | $8.5M2016 | −$190.8M2025 | — | |
| Free cash flow margin | 0.7%2016 | −31.4%2025 | −32.1 pts | |
| Stock-based compensation | $42.7M2016 | $10.7M2025 | −14.2%/yr | |
| Dividends paid | $02016 | $3,0002019 | — | |
| Share buybacks (net) | $02016 | $47.0M2025 | — | |
| Capex / revenue | 1.9%2016 | 2.0%2025 | +0.1 pts |
Change is the average annual growth (CAGR) or the difference between the first and latest year.
OPK cash flow by activity
OPK net income vs operating cash flow
Operating cash flow above net income usually means earnings are backed by cash (depreciation and stock-based pay are non-cash expenses).
OPK cash flow statement
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Operating activities | ||||||||||
| Net income | −$225.7M | −$53.2M | −$188.9M | −$328.4M | −$30.1M | $30.6M | −$314.9M | −$153.0M | −$305.2M | −$25.1M |
| Depreciation & amortization | $91.6M | $98.2M | $105.3M | $108.7M | $78.7M | $85.4M | $93.8M | $97.3M | $102.1M | $96.6M |
| Stock-based compensation | $10.7M | $11.0M | $11.4M | $18.5M | $13.6M | $8.9M | $13.4M | $21.8M | $28.3M | $42.7M |
| Change in working capital | −$41.2M | $32.2M | $21.8M | $42.7M | −$20.5M | −$97.6M | −$68.8M | −$58.1M | $48.4M | −$43.2M |
| Other non-cash items | −$14.0M | −$271.7M | $22.2M | $63.4M | −$3.4M | $12.2M | $104.0M | −$17.1M | $34.4M | −$38.9M |
| Cash from operating activities | −$178.5M | −$183.5M | −$28.2M | −$95.2M | $38.3M | $39.5M | −$172.5M | −$109.1M | −$92.1M | $32.0M |
| Investing activities | ||||||||||
| Capital expenditures | −$12.3M | −$25.0M | −$16.3M | −$24.6M | −$32.2M | −$33.7M | −$12.7M | −$27.9M | −$46.5M | −$23.5M |
| Investments (net) | $52.2M | $352.2M | −$24.7M | $91.0M | $6.1M | $15.1M | −$1.2M | $516,000 | −$9.6M | −$14.4M |
| Acquisitions & other investing | $190.4M | $25.0M | $22.7M | $24.6M | $62.0M | $245,000 | $671,000 | $1.2M | $9.5M | $17.3M |
| Cash from investing activities | $230.3M | $352.2M | −$18.2M | $91.0M | $35.9M | −$18.3M | −$13.3M | −$26.1M | −$46.7M | −$20.7M |
| Financing activities | ||||||||||
| Dividends paid | — | — | — | — | — | — | −$3,000 | — | $0 | $0 |
| Share repurchases & issuance (net) | −$47.0M | −$90.2M | −$272,000 | $0 | — | — | −$3,000 | $93.7M | $2.1M | $8.6M |
| Net borrowing (repayment) | −$70.8M | $288.0M | −$11.0M | $23.7M | −$11.4M | −$35.8M | $99.2M | $47.2M | $58.9M | −$43.8M |
| Shares issued | $0 | $0 | $0 | $0 | $1,000 | $0 | $76.1M | $92.5M | $0 | $0 |
| Other financing | −$256,000 | −$13.6M | $0 | −$774,000 | $1.1M | $756,000 | $3,000 | −$92.5M | $0 | $0 |
| Cash from financing activities | −$118.1M | $184.2M | −$11.3M | $23.0M | −$10.3M | −$35.1M | $175.2M | $140.9M | $61.0M | −$35.2M |
| Summary | ||||||||||
| Net change in cash | −$62.9M | $349.7M | −$57.3M | $18.5M | $62.5M | −$13.2M | −$11.0M | $5.0M | −$77.2M | −$24.9M |
| Cash at end of period | $382.7M | $445.6M | $95.9M | $153.2M | $134.7M | $72.2M | $85.5M | $96.5M | $91.5M | $168.7M |
| Free cash flow | −$190.8M | −$208.5M | −$44.5M | −$119.8M | $6.2M | $5.8M | −$185.3M | −$137.0M | −$138.6M | $8.5M |
| Free cash flow margin | −31.4% | −29.2% | −5.2% | −11.9% | 0.3% | 0.4% | −20.5% | −13.8% | −14.3% | 0.7% |
| Capex / revenue | 2.0% | 3.5% | 1.9% | 2.4% | 1.8% | 2.3% | 1.4% | 2.8% | 4.8% | 1.9% |
| Operating cash flow / net income | — | — | — | — | — | 1.29 | — | — | — | — |
| Jun '26 | Mar '26 | Dec '25 | Sep '25 | Jun '25 | Mar '25 | Dec '24 | Sep '24 | Jun '24 | Mar '24 | Dec '23 | Sep '23 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating activities | ||||||||||||
| Net income | −$8.4M | −$54.8M | −$31.3M | $21.6M | −$148.4M | −$67.6M | $14.0M | $24.9M | −$10.3M | −$81.8M | −$66.5M | −$84.5M |
| Depreciation & amortization | $22.4M | $22.2M | $22.4M | $22.7M | $23.0M | $23.5M | $24.0M | $24.2M | $24.2M | $25.8M | $26.0M | $26.3M |
| Stock-based compensation | $2.2M | $2.7M | $2.9M | $3.0M | $2.2M | $2.6M | $3.1M | $2.8M | $2.6M | $2.6M | $2.7M | $3.2M |
| Change in working capital | −$8.6M | $12.0M | −$12.1M | −$1.9M | −$37.9M | $10.7M | −$17.0M | −$28.9M | $14.7M | $14.2M | $2.6M | $75.0M |
| Other non-cash items | −$51.1M | −$1.4M | −$7.8M | −$80.1M | $77.7M | −$3.7M | −$68.6M | −$100.0M | −$57.6M | $3.6M | −$3.0M | $13.1M |
| Cash from operating activities | −$43.5M | −$19.3M | −$25.9M | −$34.6M | −$83.4M | −$34.6M | −$44.4M | −$77.1M | −$26.4M | −$35.6M | −$38.3M | $33.1M |
| Investing activities | ||||||||||||
| Capital expenditures | −$3.0M | −$1.8M | −$2.7M | −$3.1M | −$3.3M | −$3.2M | −$5.4M | −$7.9M | −$7.2M | −$4.4M | −$3.0M | −$4.2M |
| Investments (net) | $0 | $0 | $527,000 | $194.6M | −$2.8M | $40.5M | $116.0M | $247.8M | −$7.2M | −$4.4M | −$1.4M | −$3.6M |
| Acquisitions & other investing | $18.5M | $33,000 | $93,000 | $3.1M | $3.3M | $3.2M | $5.4M | $7.9M | $7.2M | $4.4M | $3.0M | $4.2M |
| Cash from investing activities | $15.5M | −$1.8M | −$2.0M | $194.6M | −$2.8M | $40.5M | $116.0M | $247.8M | −$7.2M | −$4.4M | −$1.4M | −$3.6M |
| Financing activities | ||||||||||||
| Share repurchases & issuance (net) | −$13.0M | −$4.8M | −$13.5M | −$15.3M | −$18.3M | $0 | −$16.5M | −$23.8M | −$208,000 | −$50.0M | $1,000 | $28,000 |
| Net borrowing (repayment) | $333,000 | −$390,000 | −$4.7M | −$928,000 | −$61.0M | −$4.1M | −$24.0M | $234.7M | — | — | — | — |
| Shares issued | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other financing | −$339,000 | $0 | −$133,000 | $0 | −$211,000 | $88,000 | $0 | −$4.8M | −$1.9M | $70.6M | −$3.8M | $2.1M |
| Cash from financing activities | −$13.0M | −$5.2M | −$18.3M | −$16.2M | −$79.5M | −$4.0M | −$40.5M | $206.1M | −$2.1M | $20.6M | −$3.8M | $2.1M |
| Summary | ||||||||||||
| Net change in cash | −$41.1M | −$27.2M | −$46.1M | $143.5M | −$164.3M | $4.1M | $25.6M | $379.5M | −$35.1M | −$20.2M | −$42.7M | $30.5M |
| Cash at end of period | $314.4M | $355.6M | $382.7M | $428.9M | $285.4M | $449.7M | $445.6M | $420.1M | $40.6M | $75.6M | $95.9M | $138.6M |
| Free cash flow | −$46.5M | −$21.1M | −$28.6M | −$37.8M | −$86.7M | −$37.7M | −$49.8M | −$85.0M | −$33.7M | −$40.0M | −$41.3M | $28.9M |
| Free cash flow margin | −28.4% | −17.0% | −19.3% | −24.9% | −55.3% | −25.2% | −27.1% | −49.0% | −18.5% | −23.0% | −22.7% | 16.2% |
| Capex / revenue | 1.8% | 1.5% | 1.8% | 2.1% | 2.1% | 2.1% | 2.9% | 4.6% | 4.0% | 2.6% | 1.7% | 2.4% |
| Operating cash flow / net income | — | — | — | −1.60 | — | — | −3.17 | −3.10 | — | — | — | — |
Negative numbers are cash paid out. Quarterly columns are labeled by the month the quarter ended. Figures in U.S. dollars as reported; data from EODHD.
OPK cash generation
In fiscal 2025 (ended December 31, 2025), OPKO Health generated -$178.5 million of cash from operations and spent $12.3 million on capital expenditures, leaving free cash flow of -$190.8 million, −31.4% of revenue. It returned $47.0 million to shareholders through dividends ($0) and net share buybacks ($47.0 million). Cash and equivalents fell by $62.9 million over the year.
Related: OPK income statement, OPK balance sheet. See the OPK stock overview for the latest quote and news.
OPK cash flow FAQ
What is OPKO Health's free cash flow?
OPKO Health's free cash flow was -$190.8 million in fiscal 2025: -$178.5 million of operating cash flow minus $12.3 million of capital expenditures It was -$208.5 million a year earlier..
How much cash does OPKO Health generate from operations?
OPKO Health generated -$178.5 million of cash from operating activities in fiscal 2025.
How much does OPKO Health spend on capital expenditures?
OPKO Health spent $12.3 million on capital expenditures in fiscal 2025, 2.0% of revenue, compared with $25.0 million the year before.
How much stock does OPKO Health buy back?
OPKO Health spent $47.0 million on net share repurchases in fiscal 2025.