Wave Life Sciences Ltd. (WVE) Key Metrics

NASDAQ: WVEValuation, returns, debt and efficiency ratios over 10 years.

WVE valuation today

Trailing 12 months · as of October 18, 2026
Market cap
$616.8M
Enterprise value
$331.3M
P/E (TTM)
—
Forward P/E
—
PEG ratio
—
Price / sales
9.4
10-yr median 15.8
Price / book
1.7
10-yr median 6.8
EV / EBITDA
—
Dividend yield
—
Beta
−1.43

WVE key metrics, 2016–2025

Fiscal year ended December 31, 2025 · U.S. dollars

WVE valuation Price multiples at each fiscal year-end price.

Price / sales+324.9%
67.1
2025 · hover or tap a bar for each year
2021: 4.02022: 151.3 (+3,707.9%)2023: 4.7 (−96.9%)2024: 15.8 (+234.0%)2025: 67.1 (+324.9%)
20162025
Price / book−33.3%
5.4
2025 · hover or tap a bar for each year
2021: 5.02023: 13.52024: 8.2 (−39.6%)2025: 5.4 (−33.3%)
20162025
Free cash flow yield+2.3 pts
−6.5%
2025 · hover or tap a bar for each year
2021: −55.0%2022: −23.4% (+31.6 pts)2023: −3.8% (+19.6 pts)2024: −8.9% (−5.0 pts)2025: −6.5% (+2.3 pts)
20162025

WVE valuation history

Fiscal year-endToday10-year median

WVE returns on capital

ROEROICROA

Net income (ROE, ROA) or after-tax operating income (ROIC) divided by the average of the opening and closing balance.

WVE debt vs cash

Total debtCash & short-term investments

Debt includes short- and long-term borrowings and, where reported, lease liabilities.

WVE cash returned to shareholders

DividendsBuybacksFree cash flow

WVE price vs earnings per share

Share price at year-endEPS (right axis)

WVE key metrics

2016–2025
Wave Life Sciences Ltd. key metrics by fiscal year
2025202420232022202120202019201820172016
Valuation
Market capitalization$2.87B$1.71B$535.8M$552.0M$162.7M—————
Enterprise value$2.28B$1.43B$367.6M$501.1M$42.1M—————
Price / sales67.115.84.7151.34.0—————
Price / book5.48.213.5—5.0—————
EV / sales53.413.23.2137.31.0—————
Earnings yield−7.1%−5.7%−10.7%−29.3%−75.1%—————
Free cash flow yield−6.5%−8.9%−3.8%−23.4%−55.0%—————
Shareholder yield (dividends + buybacks)———0.0%0.0%—————
Share price at fiscal year-end$17.00$12.37$5.05$7.00$3.14$7.87$8.02$42.04$35.10$26.15
Per share
Revenue per share$0.25$0.78$1.07$0.05$0.79—————
Earnings per share−$1.21−$0.70−$0.54−$2.05−$2.36—————
Operating cash flow per share−$1.11−$1.09−$0.18−$1.62−$1.72—————
Free cash flow per share−$1.11−$1.10−$0.19−$1.64−$1.73—————
Cash per share$3.57$2.18$1.89$1.12$2.91—————
Book value per share$3.12$1.52$0.37−$0.57$0.63—————
Tangible book value per share$3.12$1.52$0.37−$0.57$0.63—————
Capex per share$0.00$0.01$0.01$0.02$0.01—————
Debt per share$0.11$0.18$0.30$0.48$0.58—————
Shares outstanding168.6M138.3M106.1M78.9M51.8M—————
Change in shares outstanding+22.0%+30.3%+34.5%+52.2%——————
Returns & profitability
Return on equity (ROE)−55.6%−77.9%——−198.5%−184.8%−267.2%−137.6%−74.3%−38.4%
Return on assets (ROA)−41.3%−30.9%−27.3%−91.6%−50.3%−53.2%−66.7%−61.4%−58.9%−33.6%
Return on tangible assets−32.0%−27.5%−20.9%−110.5%−59.1%−53.7%−68.1%−49.6%−56.1%−33.6%
Free cash flow margin−438.8%−140.3%−18.1%—−218.6%−584.4%—−227.6%——
Financial health
Total debt$17.8M$25.4M$32.1M$37.6M$29.9M$29.3M$32.5M$10.4M$3.5M$78,000
Cash & short-term investments$602.1M$302.1M$200.4M$88.5M$150.6M$184.5M$147.2M$174.8M$142.5M$150.3M
Net debt−$584.3M−$276.7M−$168.2M−$50.9M−$120.6M−$155.2M−$114.6M−$164.4M−$139.0M−$150.2M
Debt / equity0.030.120.81—0.920.320.450.140.020.00
Debt / assets0.030.070.120.260.140.100.110.040.020.00
Current ratio6.472.891.261.382.531.901.571.567.6712.50
Quick ratio6.472.891.261.382.531.811.491.567.6712.50
Interest coverage———-103.1-8.8————-164.2
Working capital$519.7M$209.4M$48.9M$27.0M$98.4M$109.0M$67.3M$72.2M$130.9M$139.8M
Invested capital−$58.1M−$67.2M−$128.6M−$96.0M−$88.2M−$64.5M−$43.0M−$91.1M$765,000−$15.4M
Tangible asset value$526.2M$209.5M$39.6M−$45.1M$32.5M$90.7M$71.6M$73.3M$139.8M$134.9M
Net current asset value$502.5M$177.7M$54,000−$92.9M−$11.9M$41.5M−$27.2M−$20.3M$108.5M$122.0M
Graham net-net per share$2.91$1.16−$0.18−$1.31−$0.46—————
Capital allocation
Dividends paid————————$0$30.0M
Share buybacks (net)———$0$0$0$0$0$0$0
Capex / revenue1.7%0.9%1.0%37.3%1.4%6.7%24.5%68.9%509.9%374.9%
Capex / depreciation0.080.110.120.130.060.130.431.788.767.10
Stock-based compensation / revenue58.4%12.1%8.6%471.2%40.1%71.2%122.1%108.2%327.8%461.1%
R&D / revenue427.8%147.4%114.7%3,175.0%297.5%652.2%1,097.6%932.6%2,141.2%2,748.7%
SG&A / revenue176.3%54.5%45.3%1,384.3%112.6%211.7%305.8%274.1%728.3%1,077.0%
Efficiency
Days sales outstanding11.537.934.00.0133.7454.5342.6139.398.5—
Days of inventory on hand——0.0——28.020.0———
Days payables outstanding659.0613.1589.8436.631.631.923.128.128.93,600.8
Cash conversion cycle (days)-647.4-575.1-555.9-436.6102.1450.6339.5111.269.7—
Receivables turnover31.679.6210.75—2.730.801.072.623.70—
Payables turnover0.550.600.620.8411.5711.4515.8313.0012.650.10
Inventory turnover——9,206,000.00——13.0618.22———
Asset turnover0.090.350.540.020.170.070.060.060.020.01
Average receivables$1.3M$11.3M$10.5M$0$15.0M$25.0M$15.0M$5.5M$1.0M—
Average payables$16.0M$14.6M$14.9M$12.1M$10.5M$11.4M$11.1M$10.3M$6.3M$3.9M
Average inventory——$1——$10.0M$9.6M—$0$0
Intangibles / total assets0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%

Computed from WVE's annual financial statements (latest annual report filed February 26, 2026) and the closing share price on each fiscal year-end, adjusted for stock splits. Figures in U.S. dollars; data from EODHD. Averages use the opening and closing balance of each year.

WVE valuation and financial ratios

Wave Life Sciences earned a return on equity of −55.6% in fiscal 2025. It ended the year with $17.8 million of debt and $602.1 million in cash and short-term investments, a net cash position of $584.3 million.

See the WVE income statement, the WVE chart for price history, or the WVE stock overview for the latest quote and news.

WVE key metrics FAQ

What is Wave Life Sciences's return on equity?

Wave Life Sciences's return on equity (ROE) was −55.6% in fiscal 2025: net income of -$204.4 million on average shareholders' equity of $367.9 million.

How much debt does Wave Life Sciences have?

Wave Life Sciences had total debt of $17.8 million at the end of fiscal 2025, a debt-to-equity ratio of 0.03 and more cash than debt.

What is Wave Life Sciences's free cash flow yield?

Wave Life Sciences generated -$187.5 million of free cash flow in fiscal 2025, a free cash flow yield of −6.5% on its market value at year-end ($2.9 billion).

What is Wave Life Sciences's current ratio?

Wave Life Sciences's current ratio was 6.47 at the end of fiscal 2025: current assets were 6.47 times current liabilities.

Biotechnology key metrics