Septerna, Inc. (SEPN) Key Metrics
SEPN valuation today
Trailing 12 months · as of October 18, 2026- Market cap
- $1.70B
- Enterprise value
- $1.44B
- P/E (TTM)
- —
- Forward P/E
- 107.5
- PEG ratio
- —
- Price / sales
- 17.2
- Price / book
- 4.6
- EV / EBITDA
- —
- Dividend yield
- —
- Beta
- —
SEPN key metrics, 2022–2025
Fiscal year ended December 31, 2025 · U.S. dollarsSEPN valuation Price multiples at each fiscal year-end price.
SEPN returns How much profit the business earns on the capital it uses.
SEPN per-share figures Results divided by the shares outstanding at year-end.
SEPN financial health Debt, liquidity and how easily interest is covered.
SEPN efficiency & capital use Working capital cycle and where the cash goes.
SEPN valuation history
SEPN returns on capital
Net income (ROE, ROA) or after-tax operating income (ROIC) divided by the average of the opening and closing balance.
SEPN debt vs cash
Debt includes short- and long-term borrowings and, where reported, lease liabilities.
SEPN cash returned to shareholders
SEPN price vs earnings per share
SEPN key metrics
2022–2025| 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|
| Valuation | ||||
| Market capitalization | $1.23B | $851.7M | — | — |
| Enterprise value | $866.5M | $526.3M | — | — |
| Price / sales | 26.9 | 792.3 | — | — |
| Price / book | 3.2 | 2.0 | — | — |
| Price / free cash flow | 11.3 | — | — | — |
| Price / operating cash flow | 11.2 | — | — | — |
| EV / sales | 18.9 | 489.6 | — | — |
| EV / free cash flow | 7.9 | — | — | — |
| Earnings yield | −4.0% | −8.4% | — | — |
| Free cash flow yield | 8.9% | −8.2% | — | — |
| Shareholder yield (dividends + buybacks) | 0.0% | 0.0% | — | — |
| Share price at fiscal year-end | $27.88 | $22.90 | — | — |
| Per share | ||||
| Revenue per share | $1.04 | $0.03 | $0.01 | $0.00 |
| Earnings per share | −$1.10 | −$1.93 | $0.21 | −$1.42 |
| Operating cash flow per share | $2.49 | −$1.81 | −$1.99 | −$1.20 |
| Free cash flow per share | $2.48 | −$1.87 | −$2.13 | −$1.26 |
| Cash per share | $8.84 | $9.44 | $4.54 | $1.57 |
| Book value per share | $8.63 | $11.29 | −$1.97 | −$2.27 |
| Tangible book value per share | $8.63 | $11.29 | −$1.97 | −$2.27 |
| Capex per share | $0.01 | $0.06 | $0.15 | $0.07 |
| Debt per share | $0.53 | $0.68 | $0.64 | $0.04 |
| Shares outstanding | 44.3M | 37.2M | 19.5M | 19.5M |
| Change in shares outstanding | +19.0% | +90.8% | 0.0% | — |
| Returns & profitability | ||||
| Return on equity (ROE) | −12.2% | −37.6% | — | — |
| Return on invested capital (ROIC) | −117.1% | — | — | — |
| Return on assets (ROA) | −9.3% | −24.4% | 5.0% | −76.6% |
| Return on tangible assets | −8.2% | −15.7% | 3.2% | −76.6% |
| Free cash flow margin | 238.7% | — | — | — |
| Income quality (OCF / net income) | — | — | −9.26 | — |
| Financial health | ||||
| Total debt | $23.6M | $25.5M | $12.6M | $710,000 |
| Cash & short-term investments | $391.1M | $350.9M | $88.5M | $30.6M |
| Net debt | −$367.5M | −$325.4M | −$75.9M | −$29.9M |
| Debt / equity | 0.06 | 0.06 | — | — |
| Debt / assets | 0.04 | 0.06 | 0.10 | 0.02 |
| Current ratio | 4.73 | 27.77 | 16.30 | 5.75 |
| Quick ratio | 4.73 | 27.77 | 16.30 | 5.75 |
| Working capital | $324.0M | $344.0M | $105.8M | $26.3M |
| Invested capital | $14.5M | $94.6M | −$114.3M | −$74.1M |
| Tangible asset value | $381.9M | $420.0M | −$38.4M | −$44.2M |
| Net current asset value | $196.7M | $320.3M | −$56.6M | −$48.4M |
| Graham net-net per share | $4.23 | $8.48 | −$3.27 | −$2.55 |
| Capital allocation | ||||
| Share buybacks (net) | $1,000 | $1,000 | $1,000 | — |
| Dividends + buybacks / free cash flow | 0.0% | — | — | — |
| Capex / revenue | 1.1% | 195.6% | 1,906.0% | — |
| Capex / operating cash flow | 0.5% | — | — | — |
| Capex / depreciation | 0.32 | 1.50 | 3.39 | 2.23 |
| Stock-based compensation / revenue | 18.4% | 293.2% | 1,072.8% | — |
| R&D / revenue | 212.4% | 6,077.9% | 23,827.2% | — |
| SG&A / revenue | 63.5% | 1,540.6% | 6,438.4% | — |
| Efficiency | ||||
| Days sales outstanding | 59.0 | 4,057.4 | 27,527.3 | — |
| Days payables outstanding | 1,534.1 | — | — | — |
| Cash conversion cycle (days) | -1,475.0 | — | — | — |
| Receivables turnover | 6.18 | 0.09 | 0.01 | — |
| Payables turnover | 0.24 | 0.00 | 0.00 | — |
| Asset turnover | 0.09 | 0.00 | 0.00 | 0.00 |
| Average receivables | $7.4M | $11.9M | $11.4M | $0 |
| Average payables | $6.7M | $2.9M | $2.9M | $3.1M |
| Intangibles / total assets | 0.0% | 0.0% | 0.0% | 0.0% |
Computed from SEPN's annual financial statements (latest annual report filed March 9, 2026) and the closing share price on each fiscal year-end, adjusted for stock splits. Figures in U.S. dollars; data from EODHD. Averages use the opening and closing balance of each year.
SEPN valuation and financial ratios
Septerna earned a return on equity of −12.2% and a return on invested capital of −117.1% in fiscal 2025. It ended the year with $23.6 million of debt and $391.1 million in cash and short-term investments, a net cash position of $367.5 million. It returned $0.0 million to shareholders: $0 in dividends and $0.0 million in share buybacks, 0% of free cash flow.
See the SEPN income statement, the SEPN chart for price history, or the SEPN stock overview for the latest quote and news.
SEPN key metrics FAQ
What is Septerna's return on equity?
Septerna's return on equity (ROE) was −12.2% in fiscal 2025: net income of -$48.9 million on average shareholders' equity of $401.0 million.
What is Septerna's ROIC?
Septerna's return on invested capital was −117.1% in fiscal 2025, using after-tax operating income divided by average debt plus equity minus cash.
How much debt does Septerna have?
Septerna had total debt of $23.6 million at the end of fiscal 2025, a debt-to-equity ratio of 0.06 and more cash than debt.
Does Septerna buy back its shares?
Yes. Septerna spent $0.0 million on net share repurchases in fiscal 2025 Shares outstanding changed +19.0% over the year, to 44.3M..
What is Septerna's free cash flow yield?
Septerna generated $109.7 million of free cash flow in fiscal 2025, a free cash flow yield of 8.9% on its market value at year-end ($1.2 billion).
What is Septerna's current ratio?
Septerna's current ratio was 4.73 at the end of fiscal 2025: current assets were 4.73 times current liabilities.