Puma Biotechnology, Inc. (PBYI) Key Metrics
PBYI valuation today
Trailing 12 months · as of October 18, 2026- Market cap
- $507.4M
- Enterprise value
- $390.2M
- P/E (TTM)
- 19.3 10-yr median 9.5
- Forward P/E
- 3.5
- PEG ratio
- 0.03
- Price / sales
- 2.2 10-yr median 1.2
- Price / book
- 3.5 10-yr median 6.8
- EV / EBITDA
- 8.6 10-yr median 4.5
- Dividend yield
- —
- Beta
- 1.21
PBYI key metrics, 2016–2025
Fiscal year ended December 31, 2025 · U.S. dollarsPBYI valuation Price multiples at each fiscal year-end price.
PBYI returns How much profit the business earns on the capital it uses.
PBYI per-share figures Results divided by the shares outstanding at year-end.
PBYI financial health Debt, liquidity and how easily interest is covered.
PBYI efficiency & capital use Working capital cycle and where the cash goes.
PBYI valuation history
PBYI returns on capital
Net income (ROE, ROA) or after-tax operating income (ROIC) divided by the average of the opening and closing balance.
PBYI debt vs cash
Debt includes short- and long-term borrowings and, where reported, lease liabilities.
PBYI price vs earnings per share
PBYI key metrics
2016–2025| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Valuation | ||||||||||
| Market capitalization | $301.4M | $149.8M | $205.9M | $190.1M | $123.5M | $406.1M | $339.2M | $772.1M | $3.67B | $1.02B |
| Enterprise value | $232.4M | $122.9M | $221.4M | $223.3M | $158.1M | $433.6M | $347.8M | $815.6M | $3.64B | $827.7M |
| P/E ratio | 9.7 | 4.9 | 9.5 | — | — | — | — | — | — | — |
| Price / sales | 1.3 | 0.6 | 0.9 | 0.8 | 0.5 | 1.8 | 1.2 | 3.1 | 132.6 | — |
| Price / book | 2.3 | 1.6 | 3.9 | 8.8 | — | — | 19.4 | 22.5 | 68.9 | 4.9 |
| Price / free cash flow | 7.2 | 3.9 | 14.3 | — | 6.0 | — | 15.4 | — | — | — |
| Price / operating cash flow | 7.2 | 3.8 | 7.6 | — | 6.0 | 507.6 | 15.2 | — | — | — |
| EV / sales | 1.0 | 0.5 | 0.9 | 1.0 | 0.6 | 1.9 | 1.3 | 3.2 | 131.4 | — |
| EV / EBITDA | 4.4 | 2.6 | 4.7 | 10.2 | — | — | — | — | — | — |
| EV / free cash flow | 5.6 | 3.2 | 15.4 | — | 7.7 | — | 15.8 | — | — | — |
| Earnings yield | 10.3% | 20.2% | 10.5% | 0.0% | −23.6% | −14.8% | −22.3% | −14.7% | −7.9% | −27.0% |
| Free cash flow yield | 13.8% | 26.0% | 7.0% | −12.0% | 16.7% | −4.7% | 6.5% | −3.2% | −6.1% | −14.6% |
| Dividend yield | — | — | — | — | — | — | — | — | 0.0% | 0.0% |
| Shareholder yield (dividends + buybacks) | — | — | — | 0.0% | — | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Share price at fiscal year-end | $5.95 | $3.05 | $4.33 | $4.23 | $3.04 | $10.26 | $8.75 | $20.35 | $98.85 | $30.70 |
| Per share | ||||||||||
| Revenue per share | $4.51 | $4.69 | $4.96 | $5.08 | $6.23 | $5.69 | $7.02 | $6.62 | $0.75 | $0.00 |
| Earnings per share | $0.61 | $0.62 | $0.45 | $0.00 | −$0.72 | −$1.52 | −$1.95 | −$2.99 | −$7.86 | −$8.29 |
| Operating cash flow per share | $0.83 | $0.79 | $0.57 | −$0.35 | $0.51 | $0.02 | $0.58 | −$0.64 | −$4.64 | −$4.26 |
| Free cash flow per share | $0.82 | $0.79 | $0.30 | −$0.51 | $0.51 | −$0.49 | $0.57 | −$0.65 | −$6.00 | −$4.47 |
| Cash per share | $1.93 | $2.06 | $2.02 | $1.80 | $2.02 | $2.36 | $2.88 | $2.86 | $2.20 | $5.84 |
| Book value per share | $2.57 | $1.88 | $1.12 | $0.48 | −$0.06 | −$0.15 | $0.45 | $0.90 | $1.43 | $6.30 |
| Tangible book value per share | $1.76 | $0.83 | −$0.16 | −$1.09 | −$1.69 | −$2.02 | −$0.59 | −$0.27 | $0.13 | $6.30 |
| Dividends per share | — | — | — | — | — | — | — | — | $0.00 | $0.00 |
| Capex per share | $0.00 | $0.00 | $0.27 | $0.16 | $0.00 | $0.51 | $0.01 | $0.02 | $1.36 | $0.22 |
| Debt per share | $0.56 | $1.51 | $2.34 | $2.54 | $2.87 | $3.06 | $3.10 | $4.00 | $1.30 | $0.00 |
| Shares outstanding | 50.7M | 49.1M | 47.6M | 44.9M | 40.6M | 39.6M | 38.8M | 37.9M | 37.2M | 33.3M |
| Change in shares outstanding | +3.2% | +3.3% | +5.8% | +10.6% | +2.7% | +2.1% | +2.2% | +2.1% | +11.6% | +3.6% |
| Returns & profitability | ||||||||||
| Return on equity (ROE) | 28.0% | 41.6% | 57.5% | 0.0% | — | — | −292.0% | −259.3% | −222.0% | −132.8% |
| Return on invested capital (ROIC) | 51.2% | 46.1% | 50.2% | 27.3% | 3.8% | −100.8% | −115.0% | −152.9% | — | −230.4% |
| Return on assets (ROA) | 14.5% | 13.6% | 9.5% | 0.0% | −12.4% | −25.0% | −30.6% | −53.5% | −139.6% | −112.1% |
| Return on tangible assets | 17.8% | 18.7% | 12.7% | 0.0% | −18.2% | −35.3% | −38.9% | −52.9% | −249.2% | −109.2% |
| Free cash flow margin | 18.3% | 16.9% | 6.1% | −10.0% | 8.2% | −8.5% | 8.1% | −9.8% | −804.8% | — |
| Income quality (OCF / net income) | 1.34 | 1.29 | 1.25 | — | — | — | — | — | — | — |
| Financial health | ||||||||||
| Total debt | $28.5M | $74.1M | $111.5M | $114.3M | $116.6M | $121.0M | $120.2M | $151.9M | $48.5M | $0 |
| Cash & short-term investments | $97.5M | $101.0M | $95.9M | $81.1M | $82.1M | $93.4M | $111.6M | $108.4M | $81.7M | $194.5M |
| Net debt | −$69.0M | −$26.9M | $15.6M | $33.2M | $34.5M | $27.6M | $8.6M | $43.5M | −$33.2M | −$194.5M |
| Debt / equity | 0.22 | 0.80 | 2.09 | 5.29 | — | — | 6.88 | 4.43 | 0.91 | 0.00 |
| Debt / assets | 0.13 | 0.35 | 0.48 | 0.51 | 0.51 | 0.50 | 0.51 | 0.59 | 0.29 | 0.00 |
| Net debt / EBITDA | −1.29 | −0.56 | 0.33 | 1.52 | — | — | — | — | — | — |
| Current ratio | 2.00 | 1.54 | 1.57 | 1.73 | 1.28 | 1.28 | 1.83 | 3.02 | 1.82 | 6.31 |
| Quick ratio | 1.93 | 1.45 | 1.50 | 1.67 | 1.21 | 1.25 | 1.80 | 2.99 | 1.79 | 6.31 |
| Interest coverage | 5.6 | 2.5 | 2.4 | 2.0 | 0.1 | -2.2 | -5.0 | -8.6 | -406.1 | -288.7 |
| Working capital | $81.4M | $51.5M | $56.8M | $56.8M | $30.4M | $31.9M | $75.5M | $135.9M | $48.1M | $199.0M |
| Invested capital | $61.4M | $65.2M | $69.0M | $54.8M | $32.1M | $21.6M | $26.0M | $77.8M | $20.1M | $15.3M |
| Tangible asset value | $88.9M | $41.0M | −$7.4M | −$49.0M | −$68.6M | −$80.1M | −$23.0M | −$10.1M | $4.9M | $209.8M |
| Net current asset value | $76.7M | $26.4M | −$20.9M | −$66.2M | −$89.0M | −$104.0M | −$51.1M | −$21.8M | −$5.8M | $193.5M |
| Graham number | $5.96 | $5.10 | $3.39 | $0.02 | — | — | — | — | — | — |
| Graham net-net per share | $1.08 | $0.17 | −$0.87 | −$1.90 | −$2.93 | −$3.43 | −$2.13 | −$2.60 | −$0.60 | $4.55 |
| Capital allocation | ||||||||||
| Dividends paid | — | — | — | — | — | — | — | — | $0 | $0 |
| Share buybacks (net) | — | — | — | $0 | — | $0 | $0 | $0 | $0 | $0 |
| Dividends + buybacks / free cash flow | — | — | — | — | — | — | 0.0% | — | — | — |
| Capex / revenue | 0.0% | 0.0% | 5.4% | 3.1% | 0.0% | 8.9% | 0.1% | 0.2% | 182.1% | — |
| Capex / operating cash flow | 0.2% | 0.1% | 46.8% | — | 0.0% | 2,505.8% | 1.4% | — | — | — |
| Capex / depreciation | 0.01 | 0.00 | 1.10 | 0.71 | 0.00 | 2.00 | 0.04 | 0.08 | 17.94 | 6.34 |
| Stock-based compensation / revenue | 3.0% | 3.6% | 4.3% | 5.2% | 12.9% | 16.2% | 21.1% | 34.6% | 392.5% | — |
| R&D / revenue | 27.2% | 23.8% | 21.4% | 22.9% | 28.4% | 43.4% | 48.8% | 65.7% | 750.2% | — |
| SG&A / revenue | 31.2% | 35.2% | 37.9% | 39.5% | 45.9% | 52.7% | 52.0% | 58.2% | 385.2% | — |
| Efficiency | ||||||||||
| Days sales outstanding | 68.5 | 63.7 | 70.3 | 59.9 | 41.9 | 44.1 | 34.1 | 23.0 | 127.4 | — |
| Days of inventory on hand | 44.7 | 44.8 | 33.8 | 38.5 | 30.3 | 30.7 | 28.7 | 24.5 | 66.1 | — |
| Days payables outstanding | 33.2 | 35.1 | 38.8 | 58.3 | 66.6 | 144.9 | 197.6 | 255.2 | 1,555.4 | 6,010.0 |
| Cash conversion cycle (days) | 80.0 | 73.4 | 65.3 | 40.1 | 5.5 | -70.0 | -134.8 | -207.6 | -1,361.8 | — |
| Receivables turnover | 5.33 | 5.73 | 5.19 | 6.10 | 8.72 | 8.27 | 10.71 | 15.88 | 2.86 | — |
| Payables turnover | 11.01 | 10.39 | 9.41 | 6.26 | 5.48 | 2.52 | 1.85 | 1.43 | 0.23 | 0.06 |
| Inventory turnover | 8.17 | 8.15 | 10.80 | 9.47 | 12.06 | 11.89 | 12.71 | 14.87 | 5.52 | — |
| Asset turnover | 1.06 | 1.04 | 1.04 | 1.02 | 1.08 | 0.94 | 1.10 | 1.18 | 0.13 | 0.00 |
| Average receivables | $42.8M | $40.2M | $45.4M | $37.4M | $29.0M | $27.2M | $25.4M | $15.8M | $9.7M | — |
| Average payables | $5.3M | $6.2M | $6.7M | $8.8M | $11.6M | $15.6M | $19.9M | $24.2M | $23.9M | $18.9M |
| Average inventory | $7.1M | $7.9M | $5.8M | $5.8M | $5.3M | $3.3M | $2.9M | $2.3M | $1.0M | $0 |
| Intangibles / total assets | 19.1% | 24.0% | 26.4% | 31.8% | 29.2% | 30.4% | 17.2% | 17.1% | 29.2% | 0.0% |
Computed from PBYI's annual financial statements (latest annual report filed February 26, 2026) and the closing share price on each fiscal year-end, adjusted for stock splits. Figures in U.S. dollars; data from EODHD. Averages use the opening and closing balance of each year.
PBYI valuation and financial ratios
At the end of fiscal 2025 (December 31, 2025), Puma Biotechnology traded at 9.7 times earnings, against a 10-year median of 9.5. Based on the latest twelve months, the trailing P/E is 19.3 and the forward P/E is 3.5. Puma Biotechnology earned a return on equity of 28.0% and a return on invested capital of 51.2% in fiscal 2025. It ended the year with $28.5 million of debt and $97.5 million in cash and short-term investments, a net cash position of $69.0 million. The share count rose 52.1% from 33.3M to 50.7M over 9 years.
See the PBYI income statement, the PBYI chart for price history, or the PBYI stock overview for the latest quote and news.
PBYI key metrics FAQ
What is Puma Biotechnology's P/E ratio?
Puma Biotechnology's trailing P/E ratio is 19.3 based on the last twelve months of earnings (as of October 18, 2026), and its forward P/E is 3.5. At the end of fiscal 2025 it was 9.7, compared with a 10-year median of 9.5.
What is Puma Biotechnology's EV/EBITDA?
Puma Biotechnology's enterprise value was 4.4 times EBITDA at the end of fiscal 2025 (enterprise value $232.4 million, EBITDA $53.3 million); the current EV/EBITDA is 8.6.
What is Puma Biotechnology's return on equity?
Puma Biotechnology's return on equity (ROE) was 28.0% in fiscal 2025: net income of $31.1 million on average shareholders' equity of $111.2 million.
What is Puma Biotechnology's ROIC?
Puma Biotechnology's return on invested capital was 51.2% in fiscal 2025, using after-tax operating income divided by average debt plus equity minus cash.
How much debt does Puma Biotechnology have?
Puma Biotechnology had total debt of $28.5 million at the end of fiscal 2025, a debt-to-equity ratio of 0.22 and more cash than debt.
What is Puma Biotechnology's free cash flow yield?
Puma Biotechnology generated $41.7 million of free cash flow in fiscal 2025, a free cash flow yield of 13.8% on its market value at year-end ($301.4 million).
What is Puma Biotechnology's current ratio?
Puma Biotechnology's current ratio was 2.00 at the end of fiscal 2025: current assets were 2.00 times current liabilities.