Design Therapeutics, Inc. (DSGN) Key Metrics

NASDAQ: DSGNValuation, returns, debt and efficiency ratios over 7 years.

DSGN valuation today

Trailing 12 months · as of October 18, 2026
Market cap
$645.2M
Enterprise value
$568.8M
P/E (TTM)
—
Forward P/E
—
PEG ratio
—
Price / sales
—
Price / book
3.8
10-yr median 1.7
EV / EBITDA
—
Dividend yield
—
Beta
1.69

DSGN key metrics, 2019–2025

Fiscal year ended December 31, 2025 · U.S. dollars

DSGN valuation Price multiples at each fiscal year-end price.

Price / book+75.5%
2.5
2025 · hover or tap a bar for each year
2021: 2.62022: 1.7 (−32.2%)2023: 0.5 (−69.4%)2024: 1.4 (+169.9%)2025: 2.5 (+75.5%)
20192025
Free cash flow yield+2.3 pts
−10.1%
2025 · hover or tap a bar for each year
2021: −3.1%2022: −9.1% (−6.0 pts)2023: −39.6% (−30.5 pts)2024: −12.4% (+27.2 pts)2025: −10.1% (+2.3 pts)
20192025

DSGN valuation history

Fiscal year-endToday7-year median

DSGN returns on capital

ROEROICROA

Net income (ROE, ROA) or after-tax operating income (ROIC) divided by the average of the opening and closing balance.

DSGN debt vs cash

Total debtCash & short-term investments

Debt includes short- and long-term borrowings and, where reported, lease liabilities.

DSGN price vs earnings per share

Share price at year-endEPS (right axis)

DSGN key metrics

2019–2025
Design Therapeutics, Inc. key metrics by fiscal year
2025202420232022202120202019
Valuation
Market capitalization$537.8M$349.1M$148.4M$571.6M$983.6M——
Enterprise value$319.4M$106.0M−$130.4M$244.9M$603.1M——
Price / book2.51.40.51.72.6——
Earnings yield−13.0%−14.2%−45.1%−10.3%−3.6%——
Free cash flow yield−10.1%−12.4%−39.6%−9.1%−3.1%——
Shareholder yield (dividends + buybacks)0.0%0.0%0.0%0.0%0.0%——
Share price at fiscal year-end$9.38$6.17$2.65$10.26$21.41——
Per share
Revenue per share$0.00$0.00$0.00$0.00$0.00$0.00$0.03
Earnings per share−$1.22−$0.88−$1.19−$1.05−$0.77−$0.30−$0.08
Operating cash flow per share−$0.95−$0.76−$1.05−$0.92−$0.64−$0.32−$0.01
Free cash flow per share−$0.95−$0.77−$1.05−$0.94−$0.67−$0.32−$0.01
Cash per share$3.83$4.34$5.03$5.93$8.36$1.33$0.00
Book value per share$3.71$4.28$4.96$5.88$8.32−$0.42−$0.13
Tangible book value per share$3.71$4.28$4.96$5.88$8.32−$0.42−$0.13
Capex per share$0.00$0.01$0.00$0.02$0.03$0.00$0.00
Debt per share$0.03$0.04$0.05$0.07$0.08—$0.03
Shares outstanding57.3M56.6M56.0M55.7M45.9M27.2M27.2M
Change in shares outstanding+1.3%+1.1%+0.5%+21.3%+69.0%0.0%—
Returns & profitability
Return on equity (ROE)−30.7%−19.1%−22.1%−16.5%−19.2%——
Return on assets (ROA)−29.2%−18.3%−21.2%−16.0%−16.6%−45.2%—
Return on tangible assets−30.9%−19.7%−23.1%−17.2%−9.1%−22.7%—
Free cash flow margin——————−16.7%
Financial health
Total debt$1.5M$2.3M$3.0M$3.7M$3.6M—$695,000
Cash & short-term investments$219.8M$245.5M$281.8M$330.4M$384.1M$36.1M$77,000
Net debt−$218.3M−$243.1M−$278.7M−$326.7M−$380.4M−$36.1M$618,000
Debt / equity0.010.010.010.010.01——
Debt / assets0.010.010.010.010.01—7.72
Current ratio17.1429.3129.5831.1072.9615.550.02
Quick ratio17.1429.3129.5831.2072.7215.500.02
Interest coverage———-14.4-120.2——
Working capital$210.7M$239.6M$275.0M$324.3M$380.2M$33.9M−$3.6M
Invested capital−$5.8M−$1.0M−$1.1M$614,000$1.7M−$47.4M−$3.0M
Tangible asset value$212.5M$242.1M$277.7M$327.3M$382.1M−$11.3M−$3.6M
Net current asset value$210.1M$238.0M$272.6M$321.3M$377.0M−$11.6M−$3.6M
Graham net-net per share$3.62$4.18$4.84$5.69$8.19−$0.43−$0.13
Capital allocation
Share buybacks (net)$0$0$0$0$0——
Capex / revenue—————33,628.3%9.1%
Capex / depreciation0.310.570.482.2611.9215.200.04
Stock-based compensation / revenue—————199,115.0%0.0%
R&D / revenue—————2,681,415.9%198.3%
SG&A / revenue—————1,104,424.8%130.5%
Efficiency
Days sales outstanding—————16,150.4—
Days of inventory on hand———54.41,925.47,811.0—
Days payables outstanding1,319.81,263.41,687.41,819.14,271.1141,547.0547,058.6
Cash conversion cycle (days)—————-117,585.6—
Receivables turnover0.000.000.000.000.000.02—
Payables turnover0.280.290.220.200.090.000.00
Inventory turnover————0.190.05—
Asset turnover0.000.000.000.000.000.009.27
Average receivables$1.5M$1.3M$1.3M$612,500$60,000$10,000—
Average payables$2.2M$2.1M$2.5M$2.3M$1.5M$1.9M$2.5M
Average inventory———$69,500$680,500$107,000—
Intangibles / total assets0.0%0.0%0.0%0.0%0.0%0.0%0.0%

Computed from DSGN's annual financial statements (latest annual report filed March 9, 2026) and the closing share price on each fiscal year-end, adjusted for stock splits. Figures in U.S. dollars; data from EODHD. Averages use the opening and closing balance of each year.

DSGN valuation and financial ratios

Design Therapeutics earned a return on equity of −30.7% in fiscal 2025. It ended the year with $1.5 million of debt and $219.8 million in cash and short-term investments, a net cash position of $218.3 million. The share count rose 110.9% from 27.2M to 57.3M over 6 years.

See the DSGN income statement, the DSGN chart for price history, or the DSGN stock overview for the latest quote and news.

DSGN key metrics FAQ

What is Design Therapeutics's return on equity?

Design Therapeutics's return on equity (ROE) was −30.7% in fiscal 2025: net income of -$69.8 million on average shareholders' equity of $227.3 million.

How much debt does Design Therapeutics have?

Design Therapeutics had total debt of $1.5 million at the end of fiscal 2025, a debt-to-equity ratio of 0.01 and more cash than debt.

What is Design Therapeutics's free cash flow yield?

Design Therapeutics generated -$54.6 million of free cash flow in fiscal 2025, a free cash flow yield of −10.1% on its market value at year-end ($537.8 million).

What is Design Therapeutics's current ratio?

Design Therapeutics's current ratio was 17.14 at the end of fiscal 2025: current assets were 17.14 times current liabilities.

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