ALPS Medical Breakthroughs ETF (SBIO)
- Expense ratio0.49%
- Net assets$172.7M
- Dividend yield0.00%
- 1-year return+19.49%
- Holdings97
SBIO ETF price chart
SBIO quote & trading statistics
SBIO performance
Total return · as of October 18, 2026- YTD-2.19%
- 1 year+19.49%
- 3 years+25.54%/yr
- 5 years+2.42%/yr
- 10 years+9.10%/yr
- 1Y volatility
- 28.96%
- 3Y volatility
- 28.16%
- 3Y Sharpe ratio
- 0.92
Returns include reinvested distributions; 3-, 5- and 10-year figures are annualized.
SBIO top 10 holdings
| # | Symbol | Name | Weight |
|---|---|---|---|
| 1 | CGON | CG Oncology, Inc. Common stock | 3.90% |
| 2 | TVTX | Travere Therapeutics Inc | 3.47% |
| 3 | ORKA | Oruka Therapeutics, Inc. | 3.45% |
| 4 | MANE | Veradermics, Incorporated | 3.20% |
| 5 | DFTX | Definium Therapeutics, Inc. | 3.08% |
| 6 | EWTX | Edgewise Therapeutics Inc | 3.03% |
| 7 | DNTH | Dianthus Therapeutics Inc. | 2.89% |
| 8 | RLAY | Relay Therapeutics Inc | 2.72% |
| 9 | AMLX | Amylyx Pharmaceuticals Inc | 2.42% |
| 10 | ACAD | ACADIA Pharmaceuticals Inc | 2.34% |
The top 10 holdings make up 30.5% of the fund (97 holdings in total). As of October 18, 2026.
About ALPS Medical Breakthroughs ETF
The fund employs a passive management - or indexing - investment approach designed to track the performance of the underlying index. It will normally invest at least 80% of its net assets in securities that comprise the underlying index. The underlying index is comprised of small and mid-cap stocks of biotechnology companies that have one or more drugs in either Phase II or Phase III of the U.S. Food and Drug Administration clinical trials.
SBIO ETF FAQ
What is the SBIO expense ratio?
ALPS Medical Breakthroughs ETF has a net expense ratio of 0.49%, or $49.00 a year for every $10,000 invested.
How much money is in SBIO?
ALPS Medical Breakthroughs ETF has about $172.7M in net assets.
What are the top holdings of SBIO?
The largest positions in SBIO are CG Oncology, Inc. Common stock (3.90%), Travere Therapeutics Inc (3.47%), Oruka Therapeutics, Inc. (3.45%). The fund holds 97 securities in total.
How has SBIO performed?
SBIO returned +19.49% over the past year and +2.42% a year over the past five years, including reinvested distributions.
Does SBIO pay dividends?
SBIO has a dividend yield of 0.00% and pays distributions na.
When was SBIO launched?
ALPS Medical Breakthroughs ETF began trading on December 30, 2014.