ALPS Medical Breakthroughs ETF (SBIO) Holdings
SBIO holdings summary
as of Oct 25, 2026- Holdings
- 100 positions listed
- Top 10 weight
- 31.7% of net assets
- Effective holdings
- 54 equal-weight equivalent
- Largest holding
- MANE 3.98% Veradermics, Incorporated
- Annual turnover
- 83.2% of the portfolio traded
Top 1031.7%
Top 2558.5%
Top 5085.1%
All SBIO holdings
100 holdings
| # | Name | ||||||
|---|---|---|---|---|---|---|---|
| 1 | MANE | Veradermics, Incorporated | Healthcare | 3.98% | $7.3M | $4.55B | — |
| 2 | CGON | CG Oncology, Inc. | Healthcare | 3.84% | $7.1M | $5.31B | — |
| 3 | ORKA | Oruka Therapeutics, Inc. | Healthcare | 3.66% | $6.7M | $4.76B | — |
| 4 | TVTX | Travere Therapeutics, Inc. | Healthcare | 3.44% | $6.3M | $4.61B | — |
| 5 | DFTX | Definium Therapeutics, Inc. | Healthcare | 3.22% | $5.9M | $4.31B | — |
| 6 | DNTH | Dianthus Therapeutics, Inc. | Healthcare | 3.07% | $5.7M | $4.03B | — |
| 7 | EWTX | Edgewise Therapeutics, Inc. | Healthcare | 2.90% | $5.3M | $4.04B | — |
| 8 | RLAY | Relay Therapeutics, Inc. | Healthcare | 2.78% | $5.1M | $3.57B | — |
| 9 | AMLX | Amylyx Pharmaceuticals, Inc. | Healthcare | 2.47% | $4.5M | $3.31B | — |
| 10 | XENE | Xenon Pharmaceuticals Inc. | Healthcare | 2.34% | $4.3M | $3.24B | — |
| 11 | IDYA | IDEAYA Biosciences, Inc. | Healthcare | 2.33% | $4.3M | $3.17B | — |
| 12 | ACAD | ACADIA Pharmaceuticals Inc. | Healthcare | 2.27% | $4.2M | $3.29B | 8.6 |
| 13 | TARS | Tarsus Pharmaceuticals, Inc. | Healthcare | 2.09% | $3.8M | $3.19B | — |
| 14 | IRON | Disc Medicine, Inc. | Healthcare | 1.99% | $3.7M | $2.18B | — |
| 15 | DYN | Dyne Therapeutics, Inc. | Healthcare | 1.95% | $3.6M | $2.66B | — |
| 16 | DNLI | Denali Therapeutics Inc. | Healthcare | 1.93% | $3.5M | $2.81B | — |
| 17 | KH6_old | KINGHERO | Other | 1.78% | $3.3M | — | — |
| 18 | VRDN | Viridian Therapeutics, Inc. | Healthcare | 1.65% | $3.0M | $2.16B | — |
| 19 | ZLAB | Zai Lab Limited | Healthcare | 1.64% | $3.0M | $2.60B | — |
| 20 | MBX | MBX Biosciences, Inc. | Healthcare | 1.61% | $3.0M | $2.39B | — |
| 21 | CLDX | Celldex Therapeutics, Inc. | Healthcare | 1.56% | $2.9M | $2.16B | — |
| 22 | AGIO | Agios Pharmaceuticals, Inc. | Healthcare | 1.55% | $2.9M | $1.87B | — |
| 23 | SLS | SELLAS Life Sciences Group, Inc. | Healthcare | 1.52% | $2.8M | $2.02B | — |
| 24 | IMNM | Immunome, Inc. | Healthcare | 1.45% | $2.7M | $1.94B | — |
| 25 | VCEL | Vericel Corporation | Healthcare | 1.44% | $2.6M | $2.05B | 85.4 |
| 26 | VERA | Vera Therapeutics, Inc. | Healthcare | 1.42% | $2.6M | $2.01B | — |
| 27 | GLPG | Galapagos NV ADR | Healthcare | 1.37% | $2.5M | — | — |
| 28 | MLYS | Mineralys Therapeutics, Inc. | Healthcare | 1.33% | $2.4M | $1.79B | — |
| 29 | BCRX | BioCryst Pharmaceuticals, Inc. | Healthcare | 1.29% | $2.4M | $1.99B | — |
| 30 | XNCR | Xencor, Inc. | Healthcare | 1.28% | $2.4M | $1.70B | — |
| 31 | SRPT | Sarepta Therapeutics, Inc. | Healthcare | 1.28% | $2.4M | $1.81B | — |
| 32 | PVLA | Palvella Therapeutics, Inc | Healthcare | 1.20% | $2.2M | $1.73B | — |
| 33 | MAZE | Maze Therapeutics, Inc. | Healthcare | 1.20% | $2.2M | $1.53B | — |
| 34 | ZBIO | Zenas BioPharma, Inc. | Healthcare | 1.20% | $2.2M | $1.62B | — |
| 35 | KLRA | Kailera Therapeutics, Inc. | Healthcare | 1.17% | $2.2M | $1.46B | — |
| 36 | IMCR | Immunocore Holdings plc | Healthcare | 1.16% | $2.1M | $1.51B | — |
| 37 | GENB | Generate Biomedicines, Inc. | Healthcare | 1.11% | $2.0M | $1.55B | — |
| 38 | NUVB | Nuvation Bio Inc. | Healthcare | 1.09% | $2.0M | $1.56B | — |
| 39 | STOK | Stoke Therapeutics, Inc. | Healthcare | 1.09% | $2.0M | $1.56B | — |
| 40 | CMPS | COMPASS Pathways plc | Healthcare | 1.05% | $1.9M | $1.49B | — |
| 41 | GPCR | Structure Therapeutics Inc. | Healthcare | 1.04% | $1.9M | $1.50B | — |
| 42 | LBRX | LB Pharmaceuticals Inc | Healthcare | 0.87% | $1.6M | $1.19B | 367.4 |
| 43 | RAPP | Rapport Therapeutics, Inc. | Healthcare | 0.87% | $1.6M | $1.32B | — |
| 44 | NKTR | Nektar Therapeutics | Healthcare | 0.86% | $1.6M | $1.22B | — |
| 45 | TSHA | Taysha Gene Therapies, Inc. | Healthcare | 0.84% | $1.5M | $1.18B | — |
| 46 | TYRA_old | TYRA | Healthcare | 0.80% | $1.5M | — | — |
| 47 | IMTX | Immatics N.V. | Healthcare | 0.79% | $1.4M | $1.02B | — |
| 48 | BCAX | Bicara Therapeutics Inc. | Healthcare | 0.79% | $1.4M | $1.11B | — |
| 49 | VOR | Vor Biopharma Inc. | Healthcare | 0.79% | $1.4M | $977.0M | 0.1 |
| 50 | SPTX | Seaport Therapeutics, Inc. | Healthcare | 0.77% | $1.4M | $954.4M | — |
| 51 | MNKD | MannKind Corporation | Healthcare | 0.71% | $1.3M | $977.5M | — |
| 52 | MGTX | MeiraGTx Holdings plc | Healthcare | 0.64% | $1.2M | $891.3M | 10.7 |
| 53 | SGP | SpyGlass Pharma, Inc. | Healthcare | 0.63% | $1.2M | $802.8M | — |
| 54 | CRVS | Corvus Pharmaceuticals, Inc. | Healthcare | 0.63% | $1.2M | $800.8M | — |
| 55 | AVBP | ArriVent BioPharma, Inc. | Healthcare | 0.62% | $1.1M | $821.5M | — |
| 56 | RIGL | Rigel Pharmaceuticals, Inc. | Healthcare | 0.62% | $1.1M | $858.7M | 2.7 |
| 57 | ANRO | Alto Neuroscience, Inc. | Healthcare | 0.60% | $1.1M | $861.0M | — |
| 58 | KURA | Kura Oncology, Inc. | Healthcare | 0.57% | $1.0M | $807.8M | — |
| 59 | GERN | Geron Corporation | Healthcare | 0.50% | $924,602.63 | $751.7M | — |
| 60 | SLDB | Solid Biosciences Inc. | Healthcare | 0.45% | $829,474.36 | $593.0M | — |
| 61 | CADL | Candel Therapeutics, Inc. | Healthcare | 0.45% | $822,666.34 | $626.7M | — |
| 62 | FDMT | 4D Molecular Therapeutics, Inc. | Healthcare | 0.45% | $819,354.33 | $670.7M | — |
| 63 | DSGN | Design Therapeutics, Inc. | Healthcare | 0.44% | $816,226.32 | $645.2M | — |
| 64 | WVE | Wave Life Sciences Ltd. | Healthcare | 0.44% | $801,690.28 | $616.8M | — |
| 65 | OLMA | Olema Pharmaceuticals, Inc. | Healthcare | 0.43% | $794,330.26 | $575.7M | — |
| 66 | ELYM | Eliem Therapeutics Inc | Healthcare | 0.42% | $776,114.21 | — | — |
| 67 | ACRS | Aclaris Therapeutics, Inc. | Healthcare | 0.40% | $729,010.08 | $482.8M | — |
| 68 | FLGT | Fulgent Genetics, Inc. | Healthcare | 0.36% | $654,857.86 | $545.1M | — |
| 69 | NGNE | Neurogene Inc. | Healthcare | 0.33% | $607,201.73 | $465.3M | — |
| 70 | DCTH | Delcath Systems, Inc. | Healthcare | 0.33% | $600,025.71 | $488.6M | — |
| 71 | OCS | Oculis Holding AG | Healthcare | 0.32% | $592,113.69 | $449.0M | — |
| 72 | EIKN | Eikon Therapeutics, Inc. | Healthcare | 0.31% | $570,033.62 | $401.9M | — |
| 73 | AGMB | AgomAb Therapeutics NV American Depositary Shares | Healthcare | 0.30% | $556,233.58 | $407.8M | — |
| 74 | TECX | Tectonic Therapeutic Inc. | Healthcare | 0.28% | $510,049.45 | $403.7M | — |
| 75 | ALLO | Allogene Therapeutics, Inc. | Healthcare | 0.28% | $508,393.45 | $452.6M | — |
| 76 | ALT | Altimmune, Inc. | Healthcare | 0.27% | $501,217.43 | $427.9M | — |
| 77 | CCCC | C4 Therapeutics, Inc. | Healthcare | 0.27% | $487,969.39 | $340.2M | — |
| 78 | RZLT | Rezolute, Inc. | Healthcare | 0.25% | $466,993.33 | $346.3M | — |
| 79 | RLMD | Relmada Therapeutics, Inc. | Healthcare | 0.23% | $426,329.21 | $330.7M | — |
| 80 | ENTA | Enanta Pharmaceuticals, Inc. | Healthcare | 0.23% | $425,041.21 | $323.3M | — |
| 81 | XFOR | X4 Pharmaceuticals, Inc. | Healthcare | 0.22% | $405,905.16 | $256.8M | 129.5 |
| 82 | ZURA | Zura Bio Limited | Healthcare | 0.22% | $405,169.15 | $371.8M | — |
| 83 | ARCT | Arcturus Therapeutics Holdings Inc. | Healthcare | 0.21% | $382,721.09 | $293.9M | — |
| 84 | CTNM | Contineum Therapeutics, Inc. | Healthcare | 0.19% | $347,392.99 | $266.4M | — |
| 85 | FULC | Fulcrum Therapeutics, Inc. | Healthcare | 0.18% | $336,904.96 | $278.8M | — |
| 86 | SABS | SAB Biotherapeutics, Inc. | Healthcare | 0.17% | $322,000.92 | $230.2M | — |
| 87 | IMRX | Immuneering Corporation | Healthcare | 0.17% | $308,568.88 | $232.3M | — |
| 88 | IKT | Inhibikase Therapeutics, Inc. | Healthcare | 0.16% | $290,352.83 | $230.2M | — |
| 89 | MGNX | MacroGenics, Inc. | Healthcare | 0.15% | $280,600.80 | $207.0M | — |
| 90 | EVMN | Evommune, Inc. | Healthcare | 0.13% | $234,600.67 | $187.6M | — |
| 91 | BCYC | Bicycle Therapeutics plc | Healthcare | 0.12% | $225,768.64 | $241.5M | — |
| 92 | SION | Sionna Therapeutics, Inc. | Healthcare | 0.11% | $210,680.60 | $175.6M | — |
| 93 | UPB | Upstream Bio, Inc. | Healthcare | 0.11% | $202,216.58 | $151.2M | — |
| 94 | AKBA | Akebia Therapeutics, Inc. | Healthcare | 0.10% | $188,968.54 | $185.7M | — |
| 95 | IMAB | I-Mab | Healthcare | 0.10% | $185,656.53 | — | — |
| 96 | CMPX | Compass Therapeutics, Inc. | Healthcare | 0.10% | $182,528.52 | $154.9M | — |
| 97 | PRTO_old | Proteon Therapeutics Inc | Other | 0.10% | $182,344.52 | — | — |
| 98 | AVXL | Anavex Life Sciences Corp. | Healthcare | 0.09% | $162,104.46 | $121.4M | — |
| 99 | IMUX | Immunic, Inc. | Healthcare | 0.06% | $116,472.33 | $95.1M | — |
| 100 | TENX | Tenax Therapeutics, Inc. | Healthcare | 0.05% | $84,640.24 | $50.9M | — |
Weights as a percentage of net assets. Value held = weight × net assets ($184.0M). Market cap and P/E from each company's latest fundamentals (U.S.-listed stocks).
SBIO sector breakdown
| Sector | Weight | Holdings | Largest |
|---|---|---|---|
| Healthcare | 98.7% | 98 | MANE, CGON, ORKA |
| Other | 1.9% | 2 | KH6_old, PRTO_old |
Sum of the weights of the holdings in each sector.
SBIO top industries
Biotechnology
93.1%
Drug Manufacturers - Specialty & Generic
3.9%
Medical Care Facilities
1.0%
Diagnostics & Research
0.4%
Medical Devices
0.3%
SBIO overlap with other ETFs
| ETF | Fund | Overlap | Shared holdings | Expense ratio |
|---|---|---|---|---|
| IWM | iShares Russell 2000 ETF | 3.6% | 85 of 1,962 | 0.19% |
| VTI | Vanguard Total Stock Market ETF | 0.2% | 83 of 2,941 | 0.03% |
| VXUS | Vanguard Total International Stock ETF | 0.0% | 2 of 8,035 | 0.05% |
| SPY | SPDR S&P 500 ETF | 0.0% | 0 of 502 | 0.09% |
| QQQ | Invesco QQQ ETF | 0.0% | 0 of 101 | 0.17% |
| DIA | SPDR Dow Jones Industrial Average ETF | 0.0% | 0 of 30 | 0.16% |
Overlap = sum over shared holdings of the smaller of the two weights. 100% means identical portfolios.
About the SBIO portfolio
ALPS Medical Breakthroughs ETF holds 100 positions. The ten largest make up 31.7% of the fund and the top 50 85.1%, so it behaves like a portfolio of about 54 equally weighted stocks. The biggest positions are Veradermics, Incorporated (3.98%), CG Oncology, Inc. (3.84%), Oruka Therapeutics, Inc. (3.66%), Travere Therapeutics, Inc. (3.44%), Definium Therapeutics, Inc. (3.22%).
By sector, Healthcare is 98.7%, Other is 1.9%. Holdings data is from the fund's latest portfolio as reported by EODHD on October 25, 2026; positions change as the fund rebalances.
Related: SBIO chart, SBIO performance, SBIO overview.
SBIO holdings FAQ
How many holdings does SBIO have?
SBIO holds 100 positions as of October 25, 2026.
What are the top 10 holdings of SBIO?
The ten largest holdings are Veradermics, Incorporated (3.98%), CG Oncology, Inc. (3.84%), Oruka Therapeutics, Inc. (3.66%), Travere Therapeutics, Inc. (3.44%), Definium Therapeutics, Inc. (3.22%), Dianthus Therapeutics, Inc. (3.07%), Edgewise Therapeutics, Inc. (2.90%), Relay Therapeutics, Inc. (2.78%), Amylyx Pharmaceuticals, Inc. (2.47%), Xenon Pharmaceuticals Inc. (2.34%). Together they are 31.7% of the fund.
What percentage of SBIO is Veradermics, Incorporated?
Veradermics, Incorporated is the largest holding at 3.98% of net assets, about $7.3M of the fund's $184.0M.
How concentrated is SBIO?
The top 10 holdings are 31.7% of the fund. By the effective number of holdings (1 divided by the sum of squared weights) SBIO behaves like a portfolio of about 54 equally weighted stocks.