ProShares UltraShort Nasdaq Biotechnology (BIS) Holdings
BIS holdings summary
as of Oct 25, 2026- Holdings
- 104 positions listed
- Top 10 weight
- 47.9% of net assets
- Effective holdings
- 27 equal-weight equivalent
- Largest holding
- AMGN 8.23% Amgen Inc.
- Annual turnover
- 0.0% of the portfolio traded
Top 1047.9%
Top 2563.8%
Top 5077.5%
Top 10091.2%
All BIS holdings
104 holdings
| # | Name | ||||||
|---|---|---|---|---|---|---|---|
| 1 | AMGN | Amgen Inc. | Healthcare | 8.23% | $152,764.03 | $233.82B | 26.9 |
| 2 | VRTX | Vertex Pharmaceuticals Incorporated | Healthcare | 7.30% | $135,509.38 | $126.66B | 28.9 |
| 3 | GILD | Gilead Sciences, Inc. | Healthcare | 7.06% | $130,940.07 | $193.67B | — |
| 4 | BIIB | Biogen Inc. | Healthcare | 6.02% | $111,755.25 | $34.37B | 41.3 |
| 5 | ILMN | Illumina, Inc. | Healthcare | 5.82% | $108,106.47 | $39.64B | 49.0 |
| 6 | REGN | Regeneron Pharmaceuticals, Inc. | Healthcare | 4.00% | $74,295.01 | $81.41B | 19.6 |
| 7 | ALXN | Alexion Pharmaceuticals Inc | Healthcare | 3.14% | $58,230.02 | — | — |
| 8 | SGEN | Seagen Inc | Healthcare | 2.19% | $40,559.65 | — | — |
| 9 | INCY | Incyte Corporation | Healthcare | 2.17% | $40,294.25 | $22.92B | 14.4 |
| 10 | BMRN | BioMarin Pharmaceutical Inc. | Healthcare | 2.00% | $37,113.17 | $10.58B | 147.8 |
| 11 | ALNY | Alnylam Pharmaceuticals, Inc. | Healthcare | 1.55% | $28,811.57 | $31.02B | 39.1 |
| 12 | SNY | Sanofi | Healthcare | 1.33% | $24,758.20 | $97.31B | 21.4 |
| 13 | VTRS | Viatris Inc. | Healthcare | 1.33% | $24,693.24 | $21.43B | — |
| 14 | NBIX | Neurocrine Biosciences, Inc. | Healthcare | 1.21% | $22,432.71 | $13.79B | 19.9 |
| 15 | SRPT | Sarepta Therapeutics, Inc. | Healthcare | 1.10% | $20,448.71 | $1.81B | — |
| 16 | JAZZ | Jazz Pharmaceuticals plc | Healthcare | 1.06% | $19,719.33 | $13.65B | 14.4 |
| 17 | NVCR | NovoCure Limited | Healthcare | 1.05% | $19,541.16 | $1.64B | — |
| 18 | IONS | Ionis Pharmaceuticals, Inc. | Healthcare | 1.04% | $19,390.83 | $7.14B | — |
| 19 | TECH | Bio-Techne Corporation | Healthcare | 1.04% | $19,390.83 | $11.38B | 62.6 |
| 20 | GH | Guardant Health, Inc. | Healthcare | 0.98% | $18,178.90 | $21.28B | — |
| 21 | PRAH | PRA Health Sciences Inc | Healthcare | 0.85% | $15,738.35 | — | — |
| 22 | ACAD | ACADIA Pharmaceuticals Inc. | Healthcare | 0.85% | $15,738.35 | $3.29B | 8.6 |
| 23 | HZNP | Horizon Pharma PLC | Healthcare | 0.84% | $15,543.47 | — | — |
| 24 | AMRN | Amarin Corporation plc | Healthcare | 0.81% | $15,036.80 | $237.4M | — |
| 25 | ONC | BeiGene, Ltd. | Healthcare | 0.79% | $14,747.28 | $41.99B | 66.0 |
| 26 | MRNA | Moderna, Inc. | Healthcare | 0.79% | $14,747.28 | $87.04B | — |
| 27 | SYNH | Syneos Health Inc | Healthcare | 0.78% | $14,496.72 | — | — |
| 28 | ASND | Ascendis Pharma A/S | Healthcare | 0.77% | $14,307.42 | $14.82B | 17.3 |
| 29 | EXEL | Exelixis, Inc. | Healthcare | 0.76% | $14,158.94 | $15.42B | 19.6 |
| 30 | RETA | Reata Pharmaceuticals Inc | Healthcare | 0.72% | $13,316.35 | — | — |
| 31 | BLUE | Bluebird bio Inc | Healthcare | 0.68% | $12,598.10 | — | — |
| 32 | ARWR | Arrowhead Pharmaceuticals, Inc. | Healthcare | 0.68% | $12,598.10 | $7.90B | — |
| 33 | GBT | Global Blood Therapeutics Inc | Healthcare | 0.63% | $11,659.00 | — | — |
| 34 | CBPO | China Biologic Products Holdings Inc | Healthcare | 0.55% | $10,185.38 | — | — |
| 35 | BBIO | BridgeBio Pharma, Inc. | Healthcare | 0.52% | $9,662.01 | $12.98B | — |
| 36 | UTHR | United Therapeutics Corporation | Healthcare | 0.50% | $9,190.60 | $22.87B | 19.1 |
| 37 | ALLK | Allakos Inc | Healthcare | 0.50% | $9,190.60 | — | — |
| 38 | FGEN | FibroGen Inc | Healthcare | 0.49% | $9,142.35 | — | — |
| 39 | BPMC | Blueprint Medicines Corp | Healthcare | 0.47% | $8,787.86 | — | — |
| 40 | SAGE | Sage Therapeutics Inc | Healthcare | 0.47% | $8,787.86 | — | — |
| 41 | NKTR | Nektar Therapeutics | Healthcare | 0.47% | $8,787.86 | $1.22B | — |
| 42 | MRTX | Mirati Ther | Healthcare | 0.46% | $8,552.16 | — | — |
| 43 | IMMU | Immunomedics Inc | Healthcare | 0.46% | $8,466.78 | — | — |
| 44 | GWPH | GW Pharmaceuticals plc | Healthcare | 0.44% | $8,123.44 | — | — |
| 45 | ADPT | Adaptive Biotechnologies Corporation | Healthcare | 0.44% | $8,123.44 | $3.83B | — |
| 46 | MNTA | Momenta Pharmaceuticals Inc | Healthcare | 0.44% | $8,123.44 | — | — |
| 47 | ICPT | Intercept Pharmaceuticals Inc | Healthcare | 0.44% | $8,123.44 | — | — |
| 48 | RARE | Ultragenyx Pharmaceutical Inc. | Healthcare | 0.44% | $8,123.44 | $1.43B | — |
| 49 | CRSP | CRISPR Therapeutics AG | Healthcare | 0.44% | $8,123.44 | $4.76B | — |
| 50 | AGIO | Agios Pharmaceuticals, Inc. | Healthcare | 0.42% | $7,754.10 | $1.87B | — |
| 51 | DCPH | Deciphera Pharmaceuticals LLC | Healthcare | 0.42% | $7,754.10 | — | — |
| 52 | MYOK | MyoKardia Inc | Healthcare | 0.40% | $7,364.36 | — | — |
| 53 | ARGX | argenx SE | Healthcare | 0.40% | $7,345.80 | $51.51B | 31.2 |
| 54 | PTCT | PTC Therapeutics, Inc. | Healthcare | 0.40% | $7,345.80 | $4.94B | — |
| 55 | MEDP | Medpace Holdings, Inc. | Healthcare | 0.40% | $7,345.80 | $17.26B | 36.3 |
| 56 | AXSM | Axsome Therapeutics, Inc. | Healthcare | 0.39% | $7,303.11 | $8.23B | — |
| 57 | ALLO | Allogene Therapeutics, Inc. | Healthcare | 0.37% | $6,790.87 | $452.6M | — |
| 58 | ALKS | Alkermes plc | Healthcare | 0.36% | $6,623.84 | $6.92B | 108.5 |
| 59 | IOVA | Iovance Biotherapeutics, Inc. | Healthcare | 0.36% | $6,623.84 | $6.17B | — |
| 60 | GRFS | Grifols, S.A. | Healthcare | 0.36% | $6,623.84 | $5.20B | 9.9 |
| 61 | XLRN | Acceleron Pharma Inc | Healthcare | 0.36% | $6,623.84 | — | — |
| 62 | QURE | uniQure N.V. | Healthcare | 0.34% | $6,224.81 | $1.51B | — |
| 63 | HALO | Halozyme Therapeutics, Inc. | Healthcare | 0.34% | $6,224.81 | $13.83B | 35.6 |
| 64 | KOD | Kodiak Sciences Inc. | Healthcare | 0.34% | $6,224.81 | $5.39B | — |
| 65 | FOLD | Amicus Therapeutics Inc | Healthcare | 0.33% | $6,033.65 | — | — |
| 66 | KRTX | Karuna Therapeutics Inc | Healthcare | 0.32% | $5,890.74 | — | — |
| 67 | EPZM | Epizyme Inc | Healthcare | 0.32% | $5,890.74 | — | — |
| 68 | APLS | Apellis Pharmaceuticals Inc | Healthcare | 0.32% | $5,890.74 | — | — |
| 69 | CCXI_old | ChemoCentryx Inc | Financial Services | 0.32% | $5,890.74 | — | — |
| 70 | ZGNX | Zogenix Inc | Healthcare | 0.29% | $5,374.79 | — | — |
| 71 | ARNA | Arena Pharmaceuticals Inc | Healthcare | 0.27% | $5,038.87 | — | — |
| 72 | FTSV | Forty Seven Inc | Healthcare | 0.26% | $4,875.55 | — | — |
| 73 | TPTX | Turning Point Therapeutics Inc | Healthcare | 0.26% | $4,875.55 | — | — |
| 74 | DNLI | Denali Therapeutics Inc. | Healthcare | 0.26% | $4,875.55 | $2.81B | — |
| 75 | MYGN | Myriad Genetics, Inc. | Healthcare | 0.26% | $4,875.55 | $380.7M | — |
| 76 | XNCR | Xencor, Inc. | Healthcare | 0.26% | $4,875.55 | $1.70B | — |
| 77 | RARX | Ra Pharmaceuticals Inc | Healthcare | 0.26% | $4,858.84 | — | — |
| 78 | AIMT | Aimmune Therapeutics Inc | Healthcare | 0.26% | $4,858.84 | — | — |
| 79 | EIDX | Eidos Therapeutics Inc | Healthcare | 0.26% | $4,799.45 | — | — |
| 80 | PRNB | Principia Biopharma Inc | Healthcare | 0.26% | $4,799.45 | — | — |
| 81 | FATE | Fate Therapeutics, Inc. | Healthcare | 0.23% | $4,335.47 | $214.5M | — |
| 82 | INSM | Insmed Incorporated | Healthcare | 0.23% | $4,335.47 | $21.02B | — |
| 83 | ARVN | Arvinas, Inc. | Healthcare | 0.23% | $4,315.05 | $449.7M | 26.8 |
| 84 | IRWD | Ironwood Pharmaceuticals, Inc. | Healthcare | 0.23% | $4,315.05 | $578.3M | 4.5 |
| 85 | ZLAB | Zai Lab Limited | Healthcare | 0.23% | $4,315.05 | $2.60B | — |
| 86 | GLPG | Galapagos NV ADR | Healthcare | 0.23% | $4,251.95 | — | — |
| 87 | PCRX | Pacira BioSciences, Inc. | Healthcare | 0.23% | $4,251.95 | $1.45B | 103.8 |
| 88 | RGNX | REGENXBIO Inc. | Healthcare | 0.20% | $3,771.26 | $457.1M | — |
| 89 | TCDA | Tricida Inc | Healthcare | 0.20% | $3,771.26 | — | — |
| 90 | ITCI | Intra-Cellular Therapies Inc | Healthcare | 0.20% | $3,771.26 | — | — |
| 91 | AKCA | Akcea Therapeutics Inc | Healthcare | 0.19% | $3,552.26 | — | — |
| 92 | LGND | Ligand Pharmaceuticals Incorporated | Healthcare | 0.19% | $3,552.26 | $5.89B | 31.1 |
| 93 | EDIT | Editas Medicine, Inc. | Healthcare | 0.19% | $3,552.26 | $360.9M | — |
| 94 | ESPR | Esperion Therapeutics Inc | Healthcare | 0.19% | $3,552.26 | — | — |
| 95 | ALEC | Alector, Inc. | Healthcare | 0.17% | $3,231.19 | $205.4M | — |
| 96 | VCYT | Veracyte, Inc. | Healthcare | 0.17% | $3,231.19 | $3.47B | 30.8 |
| 97 | DRNA | Dicerna Pharmaceuticals Inc | Healthcare | 0.17% | $3,231.19 | — | — |
| 98 | INVA | Innoviva, Inc. | Healthcare | 0.17% | $3,231.19 | $1.50B | 4.9 |
| 99 | TBPH | Theravance Biopharma, Inc. | Healthcare | 0.16% | $3,021.47 | $884.2M | 16.4 |
| 100 | CHRS | Coherus BioSciences, Inc. | Healthcare | 0.15% | $2,828.45 | $153.0M | — |
| 101 | YMAB | Y mAbs Therapeutics | Healthcare | 0.15% | $2,828.45 | — | — |
| 102 | SUPN | Supernus Pharmaceuticals, Inc. | Healthcare | 0.15% | $2,772.77 | $2.21B | — |
| 103 | NGM | NGM Biopharmaceuticals Inc | Healthcare | 0.15% | $2,772.77 | — | — |
| 104 | HCM | HUTCHMED (China) Limited | Healthcare | 0.15% | $2,772.77 | $2.44B | 140.5 |
Weights as a percentage of net assets. Value held = weight × net assets ($1.9M). Market cap and P/E from each company's latest fundamentals (U.S.-listed stocks).
BIS sector breakdown
| Sector | Weight | Holdings | Largest |
|---|---|---|---|
| Healthcare | 91.5% | 103 | AMGN, VRTX, GILD |
| Financial Services | 0.3% | 1 | CCXI_old |
Sum of the weights of the holdings in each sector.
BIS top industries
Biotechnology
49.8%
Drug Manufacturers - General
24.6%
Diagnostics & Research
9.7%
Drug Manufacturers - Specialty & Generic
3.6%
Drug Manufacturers - Specialty & Generic
1.8%
Medical Devices
1.1%
Drug Manufacturers - General
0.4%
Shell Companies
0.3%
Pharmaceuticals
0.3%
Biotechnology & Medical Research
0.2%
BIS overlap with other ETFs
| ETF | Fund | Overlap | Shared holdings | Expense ratio |
|---|---|---|---|---|
| IBBQ | Invesco Nasdaq Biotechnology ETF | 51.6% | 55 of 245 | 0.18% |
| IBB | iShares Biotechnology ETF | 48.6% | 47 of 234 | 0.46% |
| PBE | Invesco Dynamic Biotechnology & Genome ETF | 40.5% | 17 of 31 | 0.56% |
| BIB | ProShares Ultra Nasdaq Biotechnology | 36.2% | 55 of 245 | 0.95% |
| DIA | SPDR Dow Jones Industrial Average ETF | 5.1% | 1 of 30 | 0.16% |
| QQQ | Invesco QQQ ETF | 3.3% | 6 of 101 | 0.17% |
Overlap = sum over shared holdings of the smaller of the two weights. 100% means identical portfolios.
About the BIS portfolio
ProShares UltraShort Nasdaq Biotechnology holds 104 positions. The ten largest make up 47.9% of the fund and the top 50 77.5%, so it behaves like a portfolio of about 27 equally weighted stocks. The biggest positions are Amgen Inc. (8.23%), Vertex Pharmaceuticals Incorporated (7.30%), Gilead Sciences, Inc. (7.06%), Biogen Inc. (6.02%), Illumina, Inc. (5.82%).
By sector, Healthcare is 91.5%, Financial Services is 0.3%. Holdings data is from the fund's latest portfolio as reported by EODHD on October 25, 2026; positions change as the fund rebalances.
Related: BIS chart, BIS performance, BIS dividends, BIS overview.
BIS holdings FAQ
How many holdings does BIS have?
BIS holds 104 positions as of October 25, 2026.
What are the top 10 holdings of BIS?
The ten largest holdings are Amgen Inc. (8.23%), Vertex Pharmaceuticals Incorporated (7.30%), Gilead Sciences, Inc. (7.06%), Biogen Inc. (6.02%), Illumina, Inc. (5.82%), Regeneron Pharmaceuticals, Inc. (4.00%), Alexion Pharmaceuticals Inc (3.14%), Seagen Inc (2.19%), Incyte Corporation (2.17%), BioMarin Pharmaceutical Inc. (2.00%). Together they are 47.9% of the fund.
What percentage of BIS is Amgen Inc.?
Amgen Inc. is the largest holding at 8.23% of net assets, about $152,764.03 of the fund's $1.9M.
How concentrated is BIS?
The top 10 holdings are 47.9% of the fund. By the effective number of holdings (1 divided by the sum of squared weights) BIS behaves like a portfolio of about 27 equally weighted stocks.