ProShares UltraShort Nasdaq Biotechnology (BIS)
- Expense ratio0.96%
- Net assets$1.9M
- Dividend yield5.75%
- 1-year return-48.12%
- Holdings104
BIS ETF price chart
BIS quote & trading statistics
BIS performance
Annual returns & drawdowns →- YTD-37.23%
- 1 year-48.12%
- 3 years-37.64%/yr
- 5 years-19.38%/yr
- 10 years-26.89%/yr
- 1Y volatility
- 31.82%
- 3Y volatility
- 32.15%
- 3Y Sharpe ratio
- -1.25
Returns include reinvested distributions; 3-, 5- and 10-year figures are annualized.
BIS top 10 holdings
All holdings →| # | Symbol | Name | Weight |
|---|---|---|---|
| 1 | AMGN | Amgen Inc | 8.23% |
| 2 | VRTX | Vertex Pharmaceuticals Inc | 7.30% |
| 3 | GILD | Gilead Sciences Inc | 7.06% |
| 4 | BIIB | Biogen Inc | 6.02% |
| 5 | ILMN | Illumina Inc | 5.82% |
| 6 | REGN | Regeneron Pharmaceuticals Inc | 4.00% |
| 7 | ALXN | Alexion Pharmaceuticals Inc | 3.14% |
| 8 | SGEN | Seagen Inc | 2.19% |
| 9 | INCY | Incyte Corporation | 2.17% |
| 10 | BMRN | Biomarin Pharmaceutical Inc | 2.00% |
The top 10 holdings make up 47.9% of the fund (104 holdings in total). As of October 25, 2026.
About ProShares UltraShort Nasdaq Biotechnology
The fund invests in financial instruments that ProShare Advisors believes, in combination, should produce daily returns consistent with the Daily Target. The index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies. Under normal circumstances, the fund will obtain inverse leveraged exposure to at least 80% of its total assets in components of the index or in instruments with similar economic characteristics. The fund is non-diversified.
BIS ETF FAQ
What is the BIS expense ratio?
ProShares UltraShort Nasdaq Biotechnology has a net expense ratio of 0.96%, or $96.00 a year for every $10,000 invested.
How much money is in BIS?
ProShares UltraShort Nasdaq Biotechnology has about $1.9M in net assets.
What are the top holdings of BIS?
The largest positions in BIS are Amgen Inc (8.23%), Vertex Pharmaceuticals Inc (7.30%), Gilead Sciences Inc (7.06%). The fund holds 104 securities in total.
How has BIS performed?
BIS returned -48.12% over the past year and -19.38% a year over the past five years, including reinvested distributions.
Does BIS pay dividends?
BIS has a dividend yield of 5.75% and pays distributions quarterly.
When was BIS launched?
ProShares UltraShort Nasdaq Biotechnology began trading on April 6, 2010.
ETFs similar to BIS
Funds that track the same index or whose top-10 holdings overlap most with BIS's. Overlap: shared top-10 weight as a share of the larger top-10 total of the two funds.
| Symbol | Fund | Overlap | Expense ratio | Net assets | 1-year return |
|---|---|---|---|---|---|
| BIS | ProShares UltraShort Nasdaq Biotechnology | — | 0.96% | $1.9M | -48.12% |
| IBBQ | Invesco Nasdaq Biotechnology ETF | 68% | 0.18% | $113.9M | +38.28% |
| IBB | iShares Biotechnology ETF | 63% | 0.46% | $10.73B | +33.96% |
| PBE | Invesco Dynamic Biotechnology & Genome ETF | 61% | 0.56% | $430.9M | +37.84% |
| BIB | ProShares Ultra Nasdaq Biotechnology | 51% | 0.95% | $94.8M | +73.77% |