SPDR S&P Biotech ETF (XBI)
- Expense ratio0.33%
- Net assets$10.36B
- Dividend yield0.34%
- 1-year return+41.13%
- Holdings157
XBI ETF price chart
XBI quote & trading statistics
XBI performance
Annual returns & drawdowns →- YTD+22.99%
- 1 year+41.13%
- 3 years+33.51%/yr
- 5 years+3.76%/yr
- 10 years+9.36%/yr
- 1Y volatility
- 23.19%
- 3Y volatility
- 25.83%
- 3Y Sharpe ratio
- 0.96
Returns include reinvested distributions; 3-, 5- and 10-year figures are annualized.
XBI top 10 holdings
All holdings →| # | Symbol | Name | Weight |
|---|---|---|---|
| 1 | MRNA | Moderna Inc | 2.19% |
| 2 | HALO | Halozyme Therapeutics Inc | 1.78% |
| 3 | UTHR | United Therapeutics Corporation | 1.76% |
| 4 | BIIB | Biogen Inc | 1.75% |
| 5 | NTRA | Natera Inc | 1.74% |
| 6 | EXEL | Exelixis Inc | 1.73% |
| 7 | AMGN | Amgen Inc | 1.73% |
| 8 | ABBV | AbbVie Inc | 1.70% |
| 9 | GILD | Gilead Sciences Inc | 1.58% |
| 10 | TWST | Twist Bioscience Corp | 1.58% |
The top 10 holdings make up 17.5% of the fund (157 holdings in total). As of October 25, 2026.
About SPDR S&P Biotech ETF
In seeking to track the performance of the S&P Biotechnology Select Industry Index (the index), the fund employs a sampling strategy. It generally invests substantially all, but at least 80%, of its total assets in the securities comprising the index. The index represents the biotechnology segment of the S&P Total Market Index (S&P TMI).
XBI ETF FAQ
What is the XBI expense ratio?
SPDR S&P Biotech ETF has a net expense ratio of 0.33%, or $33.00 a year for every $10,000 invested.
How much money is in XBI?
SPDR S&P Biotech ETF has about $10.36B in net assets.
What are the top holdings of XBI?
The largest positions in XBI are Moderna Inc (2.19%), Halozyme Therapeutics Inc (1.78%), United Therapeutics Corporation (1.76%). The fund holds 157 securities in total.
How has XBI performed?
XBI returned +41.13% over the past year and +3.76% a year over the past five years, including reinvested distributions.
Does XBI pay dividends?
XBI has a dividend yield of 0.34% and pays distributions quarterly.
When was XBI launched?
SPDR S&P Biotech ETF began trading on January 31, 2006.