Biotech Stocks
590 biotechnology companies listed in the US, ranked by market capitalization as of the October 26, 2026 close.
590 stocks
Data as of the October 26, 2026 close| # | ||||||||
|---|---|---|---|---|---|---|---|---|
| 1 | VRTXVertex Pharmaceuticals Incorporated | Vertex Pharmaceuticals Incorporated | $131.00B | 517.49 | −1.23% | +12.5% | +22.8% | 1.2M |
| 2 | REGNRegeneron Pharmaceuticals, Inc. | Regeneron Pharmaceuticals, Inc. | $83.20B | 807.67 | +0.33% | +16.7% | +39.7% | 725K |
| 3 | MRNAModerna, Inc. | Moderna, Inc. | $79.40B | 198.85 | −0.62% | +2.10% | +644% | 21.1M |
| 4 | ARGXargenx SE | argenx SE | $54.70B | 869.33 | −0.50% | +59.3% | +6.40% | 350K |
| 5 | ONCBeiGene, Ltd. | BeiGene, Ltd. | $41.70B | 370.87 | −1.79% | +29.6% | +19.3% | 384K |
| 6 | RVMDRevolution Medicines, Inc. | Revolution Medicines, Inc. | $39.40B | 183.90 | −1.65% | −95.2% | +238% | 2.0M |
| 7 | RPRXRoyalty Pharma plc | Royalty Pharma plc | $37.40B | 64.76 | +1.41% | +16.5% | +73.8% | 3.0M |
| 8 | ALNYAlnylam Pharmaceuticals, Inc. | Alnylam Pharmaceuticals, Inc. | $30.50B | 227.66 | +1.62% | +66.9% | −50.9% | 1.8M |
| 9 | GMABGenmab A/S | Genmab A/S | $27.50B | 44.69 | +2.04% | +24.9% | +49.5% | 3.3M |
| 10 | ROIVRoivant Sciences Ltd. | Roivant Sciences Ltd. | $26.00B | 36.05 | −1.21% | −33.5% | +97.9% | 7.7M |
| 11 | INCYIncyte Corporation | Incyte Corporation | $23.00B | 113.31 | −2.07% | +37.7% | +24.1% | 1.6M |
| 12 | BNTXBioNTech SE | BioNTech SE | $21.80B | 86.86 | −1.42% | −59.5% | −17.8% | 1.3M |
| 13 | INSMInsmed Incorporated | Insmed Incorporated | $20.40B | 93.33 | −0.06% | +296% | −41.5% | 2.7M |
| 14 | EXELExelixis, Inc. | Exelixis, Inc. | $16.10B | 65.11 | +0.90% | +10.6% | +68.2% | 2.4M |
| 15 | ASNDAscendis Pharma A/S | Ascendis Pharma A/S | $16.10B | 245.15 | +0.73% | +115% | +21.4% | 704K |
| 16 | HALOHalozyme Therapeutics, Inc. | Halozyme Therapeutics, Inc. | $14.50B | 128.01 | +1.89% | +47.7% | +93.5% | 2.3M |
| 17 | JAZZJazz Pharmaceuticals plc | Jazz Pharmaceuticals plc | $13.40B | 205.70 | −3.88% | +15.5% | +48.5% | 890K |
| 18 | BBIOBridgeBio Pharma, Inc. | BridgeBio Pharma, Inc. | $13.30B | 68.15 | −0.60% | +120% | +25.6% | 2.5M |
| 19 | SMMTSummit Therapeutics Inc. | Summit Therapeutics Inc. | $11.60B | 14.50 | −6.27% | −100% | −24.8% | 6.1M |
| 20 | TECHBio-Techne Corporation | Bio-Techne Corporation | $11.40B | 72.69 | +0.19% | +1.30% | +10.3% | 3.0M |
| 21 | BMRNBioMarin Pharmaceutical Inc. | BioMarin Pharmaceutical Inc. | $10.80B | 55.75 | −0.36% | +19.9% | +2.30% | 2.2M |
| 22 | MDGLMadrigal Pharmaceuticals, Inc. | Madrigal Pharmaceuticals, Inc. | $10.10B | 437.74 | +0.81% | +71.2% | +3.90% | 300K |
| 23 | TWSTTwist Bioscience Corporation | Twist Bioscience Corporation | $9.63B | 145.25 | +3.81% | +23.2% | +326% | 2.3M |
| 24 | KYMRKymera Therapeutics, Inc. | Kymera Therapeutics, Inc. | $9.45B | 114.84 | +3.68% | +466% | +96.1% | 743K |
| 25 | PCVXVaxcyte, Inc. | Vaxcyte, Inc. | $9.44B | 59.97 | −0.76% | 0.00% | +42.0% | 2.0M |
| 26 | KRYSKrystal Biotech, Inc. | Krystal Biotech, Inc. | $9.28B | 313.66 | +0.69% | +24.1% | +68.5% | 280K |
| 27 | CAICaris Life Sciences, Inc. | Caris Life Sciences, Inc. | $9.17B | 32.46 | +1.42% | +45.4% | +4.50% | 4.9M |
| 28 | PTGXProtagonist Therapeutics, Inc. | Protagonist Therapeutics, Inc. | $9.08B | 140.32 | +1.37% | — | +87.4% | 653K |
| 29 | CORTCorcept Therapeutics Incorporated | Corcept Therapeutics Incorporated | $8.71B | 87.13 | +1.47% | +31.7% | +20.1% | 1.2M |
| 30 | SYRESpyre Therapeutics, Inc. | Spyre Therapeutics, Inc. | $8.68B | 92.91 | +2.86% | 0.00% | +298% | 1.2M |
| 31 | CYTKCytokinetics, Incorporated | Cytokinetics, Incorporated | $8.44B | 60.73 | −0.82% | −57.1% | +5.00% | 1.9M |
| 32 | TGTXTG Therapeutics, Inc. | TG Therapeutics, Inc. | $8.39B | 54.79 | +1.14% | +70.3% | +64.4% | 1.9M |
| 33 | ARWRArrowhead Pharmaceuticals, Inc. | Arrowhead Pharmaceuticals, Inc. | $8.33B | 58.98 | +1.65% | +171% | +55.2% | 1.7M |
| 34 | IBRXImmunityBio, Inc. | ImmunityBio, Inc. | $8.28B | 7.81 | −4.99% | +93.9% | +216% | 11.6M |
| 35 | ABVXAbivax SA American Depositary Shares | Abivax SA American Depositary Shares | $7.55B | 86.50 | −1.72% | −6.80% | −4.70% | 1.1M |
| 36 | AXSMAxsome Therapeutics, Inc. | Axsome Therapeutics, Inc. | $7.55B | 144.06 | −0.68% | +45.5% | +11.2% | 750K |
| 37 | PRAXPraxis Precision Medicines, Inc. | Praxis Precision Medicines, Inc. | $7.47B | 267.39 | +5.70% | — | +53.7% | 462K |
| 38 | IONSIonis Pharmaceuticals, Inc. | Ionis Pharmaceuticals, Inc. | $7.22B | 43.42 | +1.14% | −40.7% | −38.7% | 3.2M |
| 39 | IOVAIovance Biotherapeutics, Inc. | Iovance Biotherapeutics, Inc. | $6.24B | 13.78 | −2.20% | +65.7% | +512% | 16.5M |
| 40 | LGNDLigand Pharmaceuticals Incorporated | Ligand Pharmaceuticals Incorporated | $6.15B | 308.30 | +1.57% | +33.7% | +64.9% | 242K |
| 41 | RYTMRhythm Pharmaceuticals, Inc. | Rhythm Pharmaceuticals, Inc. | $6.14B | 89.47 | +0.22% | +46.9% | −19.0% | 660K |
| 42 | ORKAOruka Therapeutics, Inc. | Oruka Therapeutics, Inc. | $5.98B | 90.33 | +12.7% | 0.00% | +232% | 902K |
| 43 | IMVTImmunovant, Inc. | Immunovant, Inc. | $5.82B | 28.17 | −0.84% | 0.00% | +48.7% | 1.4M |
| 44 | BLTEBelite Bio, Inc. | Belite Bio, Inc. | $5.77B | 143.35 | −2.70% | 0.00% | +54.4% | 183K |
| 45 | MANEVeradermics, Incorporated | Veradermics, Incorporated | $5.74B | 137.39 | −1.00% | 0.00% | — | 802K |
| 46 | KODKodiak Sciences Inc. | Kodiak Sciences Inc. | $5.63B | 89.60 | +2.25% | 0.00% | +379% | 1.7M |
| 47 | CGONCG Oncology, Inc. | CG Oncology, Inc. | $5.46B | 61.56 | −0.24% | — | +41.0% | 869K |
| 48 | MIRMMirum Pharmaceuticals, Inc. | Mirum Pharmaceuticals, Inc. | $5.41B | 83.27 | +3.58% | +37.9% | +18.9% | 727K |
| 49 | COGTCogent Biosciences, Inc. | Cogent Biosciences, Inc. | $5.36B | 30.91 | −0.96% | −100% | +104% | 2.0M |
| 50 | ERASErasca, Inc. | Erasca, Inc. | $5.24B | 14.99 | +4.17% | 0.00% | +530% | 4.4M |
| 51 | PTCTPTC Therapeutics, Inc. | PTC Therapeutics, Inc. | $5.10B | 61.07 | +0.79% | +102% | −8.00% | 1.1M |
| 52 | SRRKScholar Rock Holding Corporation | Scholar Rock Holding Corporation | $5.08B | 41.71 | +0.53% | −100% | +40.5% | 1.7M |
| 53 | DFTXDefinium Therapeutics, Inc. | Definium Therapeutics, Inc. | $4.79B | 35.68 | +0.03% | 0.00% | +188% | 2.2M |
| 54 | CRSPCRISPR Therapeutics AG | CRISPR Therapeutics AG | $4.74B | 49.01 | −0.77% | — | −27.5% | 1.6M |
| 55 | TVTXTravere Therapeutics, Inc. | Travere Therapeutics, Inc. | $4.65B | 49.97 | −0.22% | +48.2% | +78.1% | 1.7M |
| 56 | DNTHDianthus Therapeutics, Inc. | Dianthus Therapeutics, Inc. | $4.44B | 79.33 | +3.32% | +294% | +141% | 828K |
| 57 | EWTXEdgewise Therapeutics, Inc. | Edgewise Therapeutics, Inc. | $4.25B | 39.17 | −0.36% | 0.00% | +158% | 1.4M |
| 58 | ARQTArcutis Biotherapeutics, Inc. | Arcutis Biotherapeutics, Inc. | $4.00B | 31.81 | +1.96% | +59.3% | +58.2% | 2.5M |
| 59 | RLAYRelay Therapeutics, Inc. | Relay Therapeutics, Inc. | $3.97B | 18.12 | −0.33% | −48.3% | +164% | 2.7M |
| 60 | LEGNLegend Biotech Corporation | Legend Biotech Corporation | $3.97B | 20.39 | +5.81% | +51.9% | −36.0% | 2.2M |
| 61 | ABCLAbCellera Biologics Inc. | AbCellera Biologics Inc. | $3.91B | 12.08 | +2.20% | −76.3% | +113% | 6.5M |
| 62 | TNGXTango Therapeutics, Inc. | Tango Therapeutics, Inc. | $3.74B | 22.20 | −4.91% | −100% | +196% | 3.2M |
| 63 | XENEXenon Pharmaceuticals Inc. | Xenon Pharmaceuticals Inc. | $3.46B | 35.77 | +1.22% | −100% | −12.2% | 1.5M |
| 64 | ACADACADIA Pharmaceuticals Inc. | ACADIA Pharmaceuticals Inc. | $3.40B | 19.74 | +0.05% | +16.4% | −10.4% | 1.9M |
| 65 | TARSTarsus Pharmaceuticals, Inc. | Tarsus Pharmaceuticals, Inc. | $3.28B | 70.03 | +2.68% | +69.4% | +6.00% | 843K |
| 66 | CELCCelcuity Inc. | Celcuity Inc. | $3.22B | 65.80 | +0.84% | 0.00% | −7.30% | 1.2M |
| 67 | IDYAIDEAYA Biosciences, Inc. | IDEAYA Biosciences, Inc. | $3.17B | 32.88 | −5.27% | +55.4% | +12.7% | 795K |
| 68 | PBLSParabilis Medicines, Inc. | Parabilis Medicines, Inc. | $3.09B | 25.03 | +2.41% | 0.00% | — | 852K |
| 69 | VKTXViking Therapeutics, Inc. | Viking Therapeutics, Inc. | $3.08B | 24.21 | −0.78% | 0.00% | −29.7% | 4.7M |
| 70 | TLXTelix Pharmaceuticals Limited | Telix Pharmaceuticals Limited | $3.05B | 8.99 | −1.75% | +22.3% | −16.9% | 314K |
| 71 | ELVNEnliven Therapeutics, Inc. | Enliven Therapeutics, Inc. | $3.04B | 41.49 | −0.07% | 0.00% | +101% | 1.3M |
| 72 | DNLIDenali Therapeutics Inc. | Denali Therapeutics Inc. | $2.98B | 18.66 | +1.36% | −100% | +16.9% | 1.6M |
| 73 | IRONDisc Medicine, Inc. | Disc Medicine, Inc. | $2.98B | 77.66 | +4.23% | 0.00% | −9.30% | 782K |
| 74 | DYNDyne Therapeutics, Inc. | Dyne Therapeutics, Inc. | $2.94B | 15.72 | +0.64% | 0.00% | −8.20% | 2.8M |
| 75 | MRVIMaravai LifeSciences Holdings, Inc. | Maravai LifeSciences Holdings, Inc. | $2.81B | 7.58 | +3.55% | +8.50% | +122% | 3.2M |
| 76 | NRIXNurix Therapeutics, Inc. | Nurix Therapeutics, Inc. | $2.79B | 25.55 | +0.83% | — | +130% | 1.7M |
| 77 | ZLABZai Lab Limited | Zai Lab Limited | $2.73B | 24.34 | +1.29% | −3.30% | −7.50% | 1.0M |
| 78 | VRDNViridian Therapeutics, Inc. | Viridian Therapeutics, Inc. | $2.64B | 23.34 | +4.34% | +279% | +5.30% | 1.8M |
| 79 | ADMAADMA Biologics, Inc. | ADMA Biologics, Inc. | $2.48B | 11.07 | +3.60% | +2.00% | −27.1% | 2.7M |
| 80 | BEAMBeam Therapeutics Inc. | Beam Therapeutics Inc. | $2.46B | 23.79 | −1.08% | −94.2% | −14.9% | 1.8M |
| 81 | MBXMBX Biosciences, Inc. | MBX Biosciences, Inc. | $2.42B | 50.29 | +3.69% | 0.00% | +196% | 521K |
| 82 | CLDXCelldex Therapeutics, Inc. | Celldex Therapeutics, Inc. | $2.34B | 29.50 | +0.85% | −97.0% | +10.4% | 1.4M |
| 83 | NAMSNewAmsterdam Pharma Company N.V. | NewAmsterdam Pharma Company N.V. | $2.33B | 19.53 | −0.91% | −80.7% | −45.3% | 1.4M |
| 84 | SLSSELLAS Life Sciences Group, Inc. | SELLAS Life Sciences Group, Inc. | $2.29B | 11.34 | −1.73% | −82.5% | +470% | 6.3M |
| 85 | AUPHAurinia Pharmaceuticals Inc. | Aurinia Pharmaceuticals Inc. | $2.27B | 17.04 | +1.07% | +18.9% | +43.3% | 942K |
| 86 | FTREFortrea Holdings Inc. | Fortrea Holdings Inc. | $2.27B | 23.83 | +0.85% | −4.50% | +111% | 1.6M |
| 87 | RCUSArcus Biosciences, Inc. | Arcus Biosciences, Inc. | $2.26B | 17.76 | −4.21% | −74.4% | +2.60% | 1.8M |
| 88 | PHVSPharvaris N.V. | Pharvaris N.V. | $2.21B | 31.54 | +0.41% | 0.00% | +37.2% | 790K |
| 89 | VCELVericel Corporation | Vericel Corporation | $2.20B | 43.04 | +1.20% | +22.5% | +18.5% | 516K |
| 90 | AGIOAgios Pharmaceuticals, Inc. | Agios Pharmaceuticals, Inc. | $2.20B | 36.85 | −0.41% | +259% | −15.0% | 1.1M |
| 91 | BHVNBiohaven Ltd. | Biohaven Ltd. | $2.18B | 14.45 | +4.11% | 0.00% | −13.0% | 3.1M |
| 92 | XNCRXencor, Inc. | Xencor, Inc. | $2.17B | 29.18 | +15.9% | +17.5% | +121% | 1.5M |
| 93 | PGENPrecigen, Inc. | Precigen, Inc. | $2.16B | 6.04 | −2.42% | — | +39.5% | 5.2M |
| 94 | HRMYHarmony Biosciences Holdings, Inc. | Harmony Biosciences Holdings, Inc. | $2.14B | 36.83 | +1.94% | +30.3% | +21.8% | 946K |
| 95 | IMNMImmunome, Inc. | Immunome, Inc. | $2.11B | 17.89 | −0.56% | −100% | +14.0% | 1.3M |
| 96 | LKFTLakefront Biotherapeutics NV | Lakefront Biotherapeutics NV | $2.07B | 31.69 | +0.11% | −81.5% | −0.90% | 286K |
| 97 | VERAVera Therapeutics, Inc. | Vera Therapeutics, Inc. | $2.04B | 28.30 | +1.11% | 0.00% | −3.10% | 2.2M |
| 98 | RXRXRecursion Pharmaceuticals, Inc. | Recursion Pharmaceuticals, Inc. | $2.04B | 3.80 | +2.70% | −60.1% | −37.1% | 21.7M |
| 99 | ZYMEZymeworks Inc. | Zymeworks Inc. | $2.04B | 28.37 | +0.53% | −90.6% | +59.9% | 900K |
| 100 | BRVEBraveheart Bio, Inc. | Braveheart Bio, Inc. | $1.97B | 21.87 | +2.01% | 0.00% | — | 493K |
| 101 | SEPNSepterna, Inc. | Septerna, Inc. | $1.93B | 41.38 | +2.40% | — | +91.0% | 391K |
| 102 | ADRXADARx Pharmaceuticals, Inc. | ADARx Pharmaceuticals, Inc. | $1.90B | 17.81 | +1.02% | +259% | — | 763K |
| 103 | SRPTSarepta Therapeutics, Inc. | Sarepta Therapeutics, Inc. | $1.90B | 17.98 | +1.41% | −34.3% | −21.2% | 3.0M |
| 104 | VIRVir Biotechnology, Inc. | Vir Biotechnology, Inc. | $1.87B | 11.04 | +4.45% | — | +84.6% | 1.9M |
| 105 | PVLAPalvella Therapeutics, Inc | Palvella Therapeutics, Inc | $1.82B | 126.23 | +0.90% | 0.00% | +72.9% | 207K |
| 106 | MLYSMineralys Therapeutics, Inc. | Mineralys Therapeutics, Inc. | $1.82B | 20.56 | +0.05% | 0.00% | −48.5% | 1.1M |
| 107 | TRVITrevi Therapeutics, Inc. | Trevi Therapeutics, Inc. | $1.78B | 12.51 | −0.79% | 0.00% | +19.0% | 1.9M |
| 108 | ZBIOZenas BioPharma, Inc. | Zenas BioPharma, Inc. | $1.78B | 27.24 | +1.38% | −100% | +14.0% | 660K |
| 109 | MAZEMaze Therapeutics, Inc. | Maze Therapeutics, Inc. | $1.73B | 31.07 | +0.19% | 0.00% | +2.20% | 661K |
| 110 | COAGHemab Therapeutics Holdings, Inc. | Hemab Therapeutics Holdings, Inc. | $1.68B | 36.02 | +4.71% | 0.00% | — | 451K |
| 111 | URGNUroGen Pharma Ltd. | UroGen Pharma Ltd. | $1.66B | 34.04 | −1.30% | +199% | +79.4% | 910K |
| 112 | KLRAKailera Therapeutics, Inc. | Kailera Therapeutics, Inc. | $1.66B | 12.77 | −0.62% | 0.00% | — | 1.0M |
| 113 | STOKStoke Therapeutics, Inc. | Stoke Therapeutics, Inc. | $1.64B | 25.46 | +1.68% | −32.5% | −21.1% | 1.0M |
| 114 | ABSIAbsci Corporation | Absci Corporation | $1.62B | 9.45 | +2.94% | −46.4% | +121% | 3.5M |
| 115 | IMCRImmunocore Holdings plc | Immunocore Holdings plc | $1.61B | 31.28 | +0.97% | +18.3% | −5.50% | 434K |
| 116 | MESOMesoblast Limited | Mesoblast Limited | $1.61B | 12.39 | +0.90% | +391% | −26.3% | 225K |
| 117 | NBTXNanobiotix S.A. | Nanobiotix S.A. | $1.61B | 31.53 | +7.39% | −79.2% | +64.2% | 151K |
| 118 | RAREUltragenyx Pharmaceutical Inc. | Ultragenyx Pharmaceutical Inc. | $1.59B | 16.08 | +2.75% | +28.1% | −52.0% | 4.2M |
| 119 | GENBGenerate Biomedicines, Inc. | Generate Biomedicines, Inc. | $1.59B | 12.35 | −0.48% | −37.7% | — | 1.1M |
| 120 | NUVBNuvation Bio Inc. | Nuvation Bio Inc. | $1.58B | 4.51 | −1.31% | +556% | −7.00% | 5.4M |
| 121 | NTLAIntellia Therapeutics, Inc. | Intellia Therapeutics, Inc. | $1.58B | 11.26 | +0.45% | −46.2% | −56.0% | 4.3M |
| 122 | TRAXFirst Tracks Biotherapeutics | First Tracks Biotherapeutics | $1.55B | 43.48 | −1.29% | 0.00% | — | 844K |
| 123 | NVAXNovavax, Inc. | Novavax, Inc. | $1.55B | 9.40 | −3.09% | −76.3% | +10.3% | 6.3M |
| 124 | INVAInnoviva, Inc. | Innoviva, Inc. | $1.52B | 21.05 | +1.89% | +19.3% | +18.9% | 776K |
| 125 | QUREuniQure N.V. | uniQure N.V. | $1.50B | 21.65 | −3.48% | +11.0% | −64.5% | 2.0M |
| 126 | GPCRStructure Therapeutics Inc. | Structure Therapeutics Inc. | $1.50B | 21.10 | −0.42% | 0.00% | −20.0% | 1.1M |
| 127 | KRSAKorsana Biosciences, Inc. | Korsana Biosciences, Inc. | $1.46B | 32.09 | +2.49% | 0.00% | +116% | 65K |
| 128 | ANABAnaptysBio, Inc. | AnaptysBio, Inc. | $1.46B | 48.77 | +0.08% | +23.5% | +109% | 503K |
| 129 | AAPGAscentage Pharma Group International | Ascentage Pharma Group International | $1.44B | 15.45 | +0.06% | +29.3% | −56.4% | 7K |
| 130 | OCULOcular Therapeutix, Inc. | Ocular Therapeutix, Inc. | $1.42B | 6.47 | −0.46% | +0.10% | −43.7% | 3.1M |
| 131 | TYRATyra Biosciences, Inc. | Tyra Biosciences, Inc. | $1.40B | 20.42 | −0.15% | 0.00% | +43.5% | 882K |
| 132 | GHRSGH Research PLC | GH Research PLC | $1.32B | 19.18 | +6.14% | 0.00% | +37.5% | 297K |
| 133 | DMRADamora Therapeutics, Inc. | Damora Therapeutics, Inc. | $1.31B | 21.26 | +0.81% | 0.00% | +152% | 527K |
| 134 | TSHATaysha Gene Therapies, Inc. | Taysha Gene Therapies, Inc. | $1.31B | 4.01 | +1.26% | +171% | −15.6% | 3.6M |
| 135 | INBXInhibrx, Inc. | Inhibrx, Inc. | $1.30B | 88.61 | −5.11% | −100% | +54.7% | 279K |
| 136 | NKTRNektar Therapeutics | Nektar Therapeutics | $1.28B | 37.45 | +0.62% | −9.30% | −37.7% | 1.1M |
| 137 | LBRXLB Pharmaceuticals Inc | LB Pharmaceuticals Inc | $1.27B | 39.34 | +1.58% | 0.00% | +146% | 379K |
| 138 | SLNSilence Therapeutics plc | Silence Therapeutics plc | $1.23B | 19.78 | +0.56% | +197% | +171% | 2.7M |
| 139 | RAPPRapport Therapeutics, Inc. | Rapport Therapeutics, Inc. | $1.22B | 25.33 | −2.31% | 0.00% | −2.30% | 551K |
| 140 | AVLNAvalyn Pharma Inc. | Avalyn Pharma Inc. | $1.20B | 27.14 | +4.22% | 0.00% | — | 247K |
| 141 | DRTSAlpha Tau Medical Ltd. | Alpha Tau Medical Ltd. | $1.19B | 12.89 | −2.05% | 0.00% | +205% | 539K |
| 142 | KARDKardigan, Inc. | Kardigan, Inc. | $1.18B | 12.63 | −1.33% | 0.00% | — | 544K |
| 143 | SNDXSyndax Pharmaceuticals, Inc. | Syndax Pharmaceuticals, Inc. | $1.18B | 13.22 | −1.34% | +91.8% | −2.30% | 1.9M |
| 144 | REPLReplimune Group, Inc. | Replimune Group, Inc. | $1.17B | 12.47 | +8.81% | 0.00% | +41.7% | 3.5M |
| 145 | OMEROmeros Corporation | Omeros Corporation | $1.16B | 16.29 | −1.69% | +14.9% | +116% | 1.7M |
| 146 | BCAXBicara Therapeutics Inc. | Bicara Therapeutics Inc. | $1.12B | 16.89 | −1.05% | 0.00% | −1.50% | 705K |
| 147 | SPTXSeaport Therapeutics, Inc. | Seaport Therapeutics, Inc. | $1.12B | 20.83 | +1.07% | 0.00% | — | 196K |
| 148 | IMTXImmatics N.V. | Immatics N.V. | $1.09B | 7.15 | −2.19% | +93.0% | −29.8% | 766K |
| 149 | VORVor Biopharma Inc. | Vor Biopharma Inc. | $1.08B | 18.33 | +0.38% | 0.00% | −32.6% | 953K |
| 150 | MNKDMannKind Corporation | MannKind Corporation | $1.04B | 3.23 | +1.25% | +42.9% | −39.2% | 4.3M |
| 151 | JANXJanux Therapeutics, Inc. | Janux Therapeutics, Inc. | $1.02B | 16.69 | +0.18% | — | −33.0% | 819K |
| 152 | LTGOLatigo Biotherapeutics, Inc. | Latigo Biotherapeutics, Inc. | $1.01B | 15.26 | +1.60% | 0.00% | — | 344K |
| 153 | MLTXMoonLake Immunotherapeutics | MoonLake Immunotherapeutics | $1.01B | 11.81 | −0.34% | 0.00% | +24.1% | 1.6M |
| 154 | SGPSpyGlass Pharma, Inc. | SpyGlass Pharma, Inc. | $1.00B | 29.91 | +5.02% | 0.00% | — | 100K |
| 155 | RIGLRigel Pharmaceuticals, Inc. | Rigel Pharmaceuticals, Inc. | $932.0M | 49.91 | +3.70% | −22.6% | +66.5% | 263K |
| 156 | SVRASavara Inc. | Savara Inc. | $929.0M | 4.52 | +7.11% | 0.00% | +3.70% | 1.9M |
| 157 | ORICORIC Pharmaceuticals, Inc. | ORIC Pharmaceuticals, Inc. | $928.0M | 8.96 | −32.0% | 0.00% | −31.6% | 1.5M |
| 158 | ODTXOdyssey Therapeutics, Inc. | Odyssey Therapeutics, Inc. | $928.0M | 19.30 | −1.53% | 0.00% | — | 261K |
| 159 | JBIOJade Biosciences, Inc. | Jade Biosciences, Inc. | $922.0M | 14.50 | −0.62% | 0.00% | +45.0% | 893K |
| 160 | VSTMVerastem, Inc. | Verastem, Inc. | $906.0M | 10.00 | −0.40% | — | +25.8% | 3.2M |
| 161 | GLUEMonte Rosa Therapeutics, Inc. | Monte Rosa Therapeutics, Inc. | $894.0M | 10.48 | −3.32% | −61.3% | −5.90% | 1.4M |
| 162 | CGEMCullinan Oncology, Inc. | Cullinan Oncology, Inc. | $894.0M | 14.54 | +1.18% | 0.00% | +87.4% | 912K |
| 163 | MGTXMeiraGTx Holdings plc | MeiraGTx Holdings plc | $882.0M | 9.18 | −0.33% | — | +5.30% | 805K |
| 164 | CRVSCorvus Pharmaceuticals, Inc. | Corvus Pharmaceuticals, Inc. | $879.0M | 10.45 | −0.76% | 0.00% | +42.2% | 996K |
| 165 | AKTSAkoustis Technologies, Inc. | Akoustis Technologies, Inc. | $875.0M | 15.73 | 0.00% | +111% | — | 366K |
| 166 | ANROAlto Neuroscience, Inc. | Alto Neuroscience, Inc. | $868.0M | 22.11 | +0.64% | 0.00% | +101% | 562K |
| 167 | IVAInventiva S.A. | Inventiva S.A. | $865.0M | 3.66 | −1.35% | −76.7% | −41.0% | 1.9M |
| 168 | OBXObsidian Therapeutics, Inc. | Obsidian Therapeutics, Inc. | $856.0M | 13.86 | −0.86% | 0.00% | — | 373K |
| 169 | KURAKura Oncology, Inc. | Kura Oncology, Inc. | $856.0M | 9.62 | +0.10% | +36.5% | −0.80% | 1.9M |
| 170 | ALMSAlumis Inc. | Alumis Inc. | $843.0M | 6.51 | −3.98% | −37.7% | +44.3% | 2.6M |
| 171 | PHARPharming Group N.V. | Pharming Group N.V. | $842.0M | 11.90 | +6.25% | −3.20% | −12.5% | 25K |
| 172 | APMDApnimed, Inc. | Apnimed, Inc. | $789.0M | 18.95 | −0.21% | −29.4% | — | 490K |
| 173 | ARDXArdelyx, Inc. | Ardelyx, Inc. | $775.0M | 3.00 | −2.60% | +23.8% | −40.5% | 4.5M |
| 174 | AVBPArriVent BioPharma, Inc. | ArriVent BioPharma, Inc. | $757.0M | 15.36 | −26.9% | 0.00% | −17.4% | 1.2M |
| 175 | HELPCybin Inc. | Cybin Inc. | $757.0M | 10.36 | +1.67% | 0.00% | +67.9% | 1.7M |
| 176 | GERNGeron Corporation | Geron Corporation | $739.0M | 1.15 | +2.68% | +17.2% | −7.30% | 10.1M |
| 177 | SANASana Biotechnology, Inc. | Sana Biotechnology, Inc. | $706.0M | 2.36 | +1.29% | 0.00% | −57.8% | 3.2M |
| 178 | ANNXAnnexon, Inc. | Annexon, Inc. | $701.0M | 3.70 | −1.33% | 0.00% | +15.3% | 3.1M |
| 179 | SLBTSL Science Holding Limited | SL Science Holding Limited | $690.0M | 1.23 | +6.96% | −7.60% | −88.1% | 71K |
| 180 | ANLAdlai Nortye Ltd. ADR | Adlai Nortye Ltd. ADR | $681.0M | 10.58 | 0.00% | +178% | +540% | 217K |
| 181 | SGMTSagimet Biosciences Inc. | Sagimet Biosciences Inc. | $675.0M | 9.56 | −0.21% | 0.00% | +4.60% | 1.3M |
| 182 | DNAGinkgo Bioworks Holdings, Inc. | Ginkgo Bioworks Holdings, Inc. | $675.0M | 10.02 | +0.30% | −48.5% | −26.2% | 2.1M |
| 183 | ACHVAchieve Life Sciences, Inc. | Achieve Life Sciences, Inc. | $674.0M | 6.54 | +0.77% | 0.00% | +30.8% | 1.4M |
| 184 | IMMXImmix Biopharma, Inc. | Immix Biopharma, Inc. | $668.0M | 8.06 | −1.10% | 0.00% | +123% | 1.6M |
| 185 | PRMEPrime Medicine, Inc. | Prime Medicine, Inc. | $655.0M | 3.61 | −1.63% | +3.50% | −32.3% | 3.6M |
| 186 | OABIOmniAb, Inc. | OmniAb, Inc. | $653.0M | 4.61 | −1.07% | +244% | +183% | 1.6M |
| 187 | DSGNDesign Therapeutics, Inc. | Design Therapeutics, Inc. | $647.0M | 10.34 | +0.98% | 0.00% | +80.5% | 599K |
| 188 | LXRXLexicon Pharmaceuticals, Inc. | Lexicon Pharmaceuticals, Inc. | $645.0M | 1.45 | +2.11% | −97.6% | +2.10% | 2.8M |
| 189 | ABUSArbutus Biopharma Corporation | Arbutus Biopharma Corporation | $644.0M | 4.20 | 0.00% | −90.6% | −3.70% | 4.9M |
| 190 | GYREGyre Therapeutics, Inc. | Gyre Therapeutics, Inc. | $644.0M | 6.07 | +3.76% | −2.10% | −25.7% | 120K |
| 191 | AURAAura Biosciences, Inc. | Aura Biosciences, Inc. | $641.0M | 6.18 | −1.90% | 0.00% | +5.50% | 859K |
| 192 | ATTOAttovia Therapeutics, Inc. | Attovia Therapeutics, Inc. | $634.0M | 13.88 | +0.36% | 0.00% | — | 442K |
| 193 | WVEWave Life Sciences Ltd. | Wave Life Sciences Ltd. | $633.0M | 3.21 | +0.94% | −73.9% | −55.0% | 3.2M |
| 194 | DBVTDBV Technologies S.A. | DBV Technologies S.A. | $627.0M | 9.98 | +2.36% | −53.3% | −35.2% | 362K |
| 195 | SLDBSolid Biosciences Inc. | Solid Biosciences Inc. | $623.0M | 5.81 | −1.86% | −100% | +3.40% | 1.2M |
| 196 | CRMDCorMedix Inc. | CorMedix Inc. | $619.0M | 7.94 | +1.15% | +156% | −28.9% | 1.1M |
| 197 | FDMT4D Molecular Therapeutics, Inc. | 4D Molecular Therapeutics, Inc. | $609.0M | 11.03 | +2.13% | — | −2.70% | 991K |
| 198 | NVCTNuvectis Pharma, Inc. | Nuvectis Pharma, Inc. | $604.0M | 18.49 | −7.78% | 0.00% | +198% | 205K |
| 199 | CADLCandel Therapeutics, Inc. | Candel Therapeutics, Inc. | $596.0M | 7.79 | −2.99% | 0.00% | +44.3% | 1.2M |
| 200 | OLMAOlema Pharmaceuticals, Inc. | Olema Pharmaceuticals, Inc. | $579.0M | 6.62 | +3.28% | 0.00% | −17.6% | 1.1M |
| 201 | ZVRAZevra Therapeutics, Inc. | Zevra Therapeutics, Inc. | $566.0M | 9.53 | −2.85% | +53.3% | −10.2% | 928K |
| 202 | MDXGMiMedx Group, Inc. | MiMedx Group, Inc. | $562.0M | 3.85 | −1.53% | −34.7% | −43.0% | 1.3M |
| 203 | PBYIPuma Biotechnology, Inc. | Puma Biotechnology, Inc. | $560.0M | 10.85 | −1.54% | +7.80% | +108% | 329K |
| 204 | ACRSAclaris Therapeutics, Inc. | Aclaris Therapeutics, Inc. | $558.0M | 3.79 | +1.07% | −8.30% | +76.3% | 2.8M |
| 205 | STTKShattuck Labs, Inc. | Shattuck Labs, Inc. | $556.0M | 5.54 | +0.91% | −66.6% | +188% | 1.1M |
| 206 | PROKProKidney Corp. | ProKidney Corp. | $543.0M | 1.36 | −3.55% | −32.1% | −57.5% | 1.3M |
| 207 | ETRAElectra Therapeutics, Inc. | Electra Therapeutics, Inc. | $525.0M | 8.37 | −3.90% | 0.00% | — | 663K |
| 208 | BLSMBlossomHill Therapeutics, Inc. | BlossomHill Therapeutics, Inc. | $521.0M | 16.39 | +12.0% | 0.00% | — | 232K |
| 209 | VALNValneva SE | Valneva SE | $513.0M | 5.41 | +2.85% | −27.7% | −43.4% | 78K |
| 210 | CLYMClimb Bio Inc | Climb Bio Inc | $506.0M | 8.81 | −13.5% | 0.00% | +343% | 1.4M |
| 211 | DRUGBright Minds Biosciences Inc. | Bright Minds Biosciences Inc. | $504.0M | 51.09 | −2.65% | 0.00% | −16.5% | 135K |
| 212 | ENTXEntera Bio Ltd. | Entera Bio Ltd. | $497.0M | 2.86 | −2.05% | −100% | +28.8% | 552K |
| 213 | OCSOculis Holding AG | Oculis Holding AG | $490.0M | 7.96 | +0.76% | +18.8% | −62.5% | 261K |
| 214 | CTMXCytomX Therapeutics, Inc. | CytomX Therapeutics, Inc. | $485.0M | 2.23 | −4.09% | −92.4% | −31.7% | 3.4M |
| 215 | PHATPhathom Pharmaceuticals, Inc. | Phathom Pharmaceuticals, Inc. | $481.0M | 5.94 | +3.48% | +88.0% | −56.1% | 1.5M |
| 216 | CBIOCrescent Biopharma, Inc. | Crescent Biopharma, Inc. | $474.0M | 12.76 | −0.47% | 0.00% | +0.60% | 353K |
| 217 | MNPRMonopar Therapeutics Inc. | Monopar Therapeutics Inc. | $473.0M | 70.54 | −0.16% | 0.00% | −13.5% | 181K |
| 218 | ARVNArvinas, Inc. | Arvinas, Inc. | $472.0M | 7.31 | +0.14% | — | −20.6% | 814K |
| 219 | DMACDiaMedica Therapeutics Inc. | DiaMedica Therapeutics Inc. | $471.0M | 8.74 | +0.23% | 0.00% | +27.0% | 181K |
| 220 | NGNENeurogene Inc. | Neurogene Inc. | $471.0M | 23.54 | −0.04% | 0.00% | −21.2% | 277K |
| 221 | EPRXEupraxia Pharmaceuticals Inc. | Eupraxia Pharmaceuticals Inc. | $453.0M | 6.85 | −0.29% | 0.00% | +25.2% | 634K |
| 222 | INDPIndaptus Therapeutics, Inc. | Indaptus Therapeutics, Inc. | $445.0M | 3.34 | +5.70% | 0.00% | −8.00% | 915K |
| 223 | FTHFaeth Therapeutics, Inc. | Faeth Therapeutics, Inc. | $435.0M | 16.83 | −1.46% | 0.00% | +59.4% | 362K |
| 224 | RGNXREGENXBIO Inc. | REGENXBIO Inc. | $434.0M | 6.58 | −1.50% | +406% | −49.5% | 1.4M |
| 225 | PRTAProthena Corporation plc | Prothena Corporation plc | $431.0M | 8.40 | +2.44% | −77.1% | −14.5% | 470K |
| 226 | MPLTMapLight Therapeutics, Inc. | MapLight Therapeutics, Inc. | $426.0M | 7.66 | −3.89% | 0.00% | — | 614K |
| 227 | AGMBAgomAb Therapeutics NV American Depositary Shares | AgomAb Therapeutics NV American Depositary Shares | $422.0M | 8.57 | −5.30% | 0.00% | — | 138K |
| 228 | OVIDOvid Therapeutics Inc. | Ovid Therapeutics Inc. | $421.0M | 2.16 | −0.23% | −88.3% | +32.2% | 1.6M |
| 229 | ALLOAllogene Therapeutics, Inc. | Allogene Therapeutics, Inc. | $418.0M | 1.21 | −3.20% | −100% | +0.80% | 5.8M |
| 230 | ASMBAssembly Biosciences, Inc. | Assembly Biosciences, Inc. | $400.0M | 19.67 | −0.86% | +38.9% | −32.7% | 292K |
| 231 | ALTAltimmune, Inc. | Altimmune, Inc. | $399.0M | 2.05 | −3.30% | +420% | −48.1% | 4.1M |
| 232 | AUTLAutolus Therapeutics plc | Autolus Therapeutics plc | $397.0M | 1.53 | −0.65% | +118% | 0.00% | 2.2M |
| 233 | TECXTectonic Therapeutic Inc. | Tectonic Therapeutic Inc. | $390.0M | 19.95 | −0.60% | 0.00% | +16.3% | 221K |
| 234 | SPRYARS Pharmaceuticals, Inc. | ARS Pharmaceuticals, Inc. | $390.0M | 3.92 | −2.73% | +114% | −57.0% | 1.7M |
| 235 | TRXBTRex Bio, Inc. | TRex Bio, Inc. | $381.0M | 13.87 | +0.43% | 0.00% | — | — |
| 236 | YDESYD Bio Ltd | YD Bio Ltd | $375.0M | 5.29 | +6.87% | +315% | −69.2% | 302K |
| 237 | RZLTRezolute, Inc. | Rezolute, Inc. | $369.0M | 3.82 | −0.91% | 0.00% | −58.4% | 1.5M |
| 238 | EDITEditas Medicine, Inc. | Editas Medicine, Inc. | $369.0M | 2.40 | 0.00% | +232% | −35.5% | 2.6M |
| 239 | CCCCC4 Therapeutics, Inc. | C4 Therapeutics, Inc. | $367.0M | 2.98 | −2.61% | +2.80% | +21.6% | 2.4M |
| 240 | AVTXAvalo Therapeutics, Inc. | Avalo Therapeutics, Inc. | $363.0M | 6.77 | −2.31% | −69.3% | −61.5% | 1.5M |
| 241 | FENCFennec Pharmaceuticals Inc. | Fennec Pharmaceuticals Inc. | $356.0M | 10.15 | +0.69% | +85.2% | +12.9% | 187K |
| 242 | ENTAEnanta Pharmaceuticals, Inc. | Enanta Pharmaceuticals, Inc. | $350.0M | 12.00 | +3.09% | −21.6% | +14.2% | 243K |
| 243 | RLMDRelmada Therapeutics, Inc. | Relmada Therapeutics, Inc. | $345.0M | 3.23 | −1.22% | 0.00% | +53.8% | 1.3M |
| 244 | CAPRCapricor Therapeutics, Inc. | Capricor Therapeutics, Inc. | $334.0M | 5.74 | −3.20% | −7.90% | −7.40% | 6.4M |
| 245 | AVIRAtea Pharmaceuticals, Inc. | Atea Pharmaceuticals, Inc. | $334.0M | 4.16 | +2.97% | +295% | +29.6% | 294K |
| 246 | OBIOOrchestra BioMed Holdings, Inc. | Orchestra BioMed Holdings, Inc. | $334.0M | 5.55 | −0.72% | −89.5% | +40.2% | 330K |
| 247 | KYTXKyverna Therapeutics, Inc. | Kyverna Therapeutics, Inc. | $326.0M | 5.27 | −2.23% | 0.00% | −29.2% | 825K |
| 248 | XFORX4 Pharmaceuticals, Inc. | X4 Pharmaceuticals, Inc. | $322.0M | 3.25 | +0.31% | +346% | −14.5% | 841K |
| 249 | TTRXTurn Therapeutics Inc. | Turn Therapeutics Inc. | $322.0M | 10.61 | +3.21% | 0.00% | +109% | 105K |
| 250 | GALTGalectin Therapeutics Inc. | Galectin Therapeutics Inc. | $322.0M | 3.19 | 0.00% | 0.00% | −39.0% | 301K |
Showing the top 250 of 590 stocks. See all 590 in the stock screener.
End-of-day data from EODHD. Click a column heading to sort. Market cap in US dollars; P/E and yields that are negative or not meaningful are shown as —.
How this list is built
- Industry: Biotechnology
- Common stocks and ADRs on the NYSE, Nasdaq and NYSE American
- Ranked by market cap
Biotechnology companies develop medicines from living systems, such as antibodies, gene therapies and vaccines. A few large biotechs sell many approved drugs; most smaller ones have no product revenue yet and depend on clinical trial results and new funding.
Because many biotechs are not profitable, P/E is not shown. Prices of small biotechs can move a lot on trial and regulatory news. This page shows the largest 250; the full list is in the stock screener.
Want to refine this list? Open it in the stock screener and add filters for valuation, dividends, performance and more.
Biotech Stocks FAQ
What are the largest biotech stocks?
By market capitalization as of October 26, 2026: Vertex Pharmaceuticals Incorporated (VRTX), $131.0 billion; Regeneron Pharmaceuticals, Inc. (REGN), $83.2 billion; Moderna, Inc. (MRNA), $79.4 billion; argenx SE (ARGX), $54.7 billion and BeiGene, Ltd. (ONC), $41.7 billion.
How many biotech stocks are there?
There are 590 biotechnology stocks on US exchanges; 154 of them are worth at least $1 billion.
Which biotech stocks performed best over the past year?
Among biotechs worth at least $1 billion, the biggest 1-year gains were Moderna, Inc. (MRNA), +644%; Erasca, Inc. (ERAS), +530%; Iovance Biotherapeutics, Inc. (IOVA), +512%; SELLAS Life Sciences Group, Inc. (SLS), +470% and Kodiak Sciences Inc. (KOD), +379%.
Why are biotech stocks so volatile?
A small biotech's value often rests on one or two drugs in development, so a trial result or an FDA decision can move the stock by 50% or more in a day.
What is the difference between biotech and pharmaceutical companies?
Pharmaceutical companies traditionally make small-molecule chemical drugs and have large sales forces; biotechs work with biologic medicines. The line has blurred, and many large drug makers now also sell biologics.