Silence Therapeutics plc (SLN) Ownership

NASDAQ: SLNTop holders, insider trades and short interest.

SLN ownership summary

as of October 18, 2026
Institutions
49.3%
of shares outstanding
Insiders
7.97%
of shares outstanding
Shares outstanding
62.2M
Float
37.9M
shares available to trade
Short interest
5.02%
2.5M shares short
Days to cover
3.00
short interest up 16.5% vs prior month
  • Institutions 49.32%
  • Insiders 7.97%
  • Other investors 42.72%

SLN top institutional holders

20 largest
Silence Therapeutics plc top institutional holders
#Holder% of sharesSharesValueChangeReported
1Siren, L.L.C.5.33%3.3M$28.7M+400,000 (+13.7%)June 30, 2026
2TCG Crossover Management, LLC4.88%3.0M$26.3M—June 30, 2026
3Nantahala Capital Management, LLC4.33%2.7M$23.4M+546,731 (+25.5%)June 30, 2026
4Redmile Group, LLC3.48%2.2M$18.8M—June 30, 2026
5Citadel Advisors Llc2.14%1.3M$11.5M+94,818 (+7.7%)June 30, 2026
6Nextech Invest, Ltd.1.53%952K$8.3M—June 30, 2026
7Millennium Management LLC1.46%909K$7.9M−164,912 (−15.4%)June 30, 2026
8Ikarian Capital, LLC1.34%831K$7.2M−35,000 (−4.0%)June 30, 2026
9Polygon Management Ltd1.23%764K$6.6M+134,095 (+21.3%)June 30, 2026
10Soleus Capital Management, L.P.1.01%630K$5.5M+630,000 (0.0%)June 30, 2026
11Balyasny Asset Management LLC0.98%611K$5.3M+610,980 (0.0%)June 30, 2026
125AM Venture Management, LLC0.77%476K$4.1M—June 30, 2026
13Great Point Partners LLC0.72%450K$3.9M−570,489 (−55.9%)June 30, 2026
14Morgan Stanley - Brokerage Accounts0.65%403K$3.5M+337,686 (+515.7%)June 30, 2026
15Ameriprise Financial Inc0.60%370K$3.2M+370,052 (0.0%)June 30, 2026
16Jane Street Group LLC0.59%369K$3.2M+268,224 (+265.8%)June 30, 2026
17ADAR1 Capital Management LLC0.54%338K$2.9M+166,216 (+96.5%)June 30, 2026
18SummitTX Capital, L.P0.53%327K$2.8M+326,648 (0.0%)June 30, 2026
19Schonfeld Strategic Advisors LLC0.43%269K$2.3M+269,348 (0.0%)June 30, 2026
20UBS Group AG0.39%243K$2.1M−3,785 (−1.5%)June 30, 2026

Value at the latest close. Change = shares bought or sold in the latest quarterly filing (13F). In the top 20, 12 holders added 4.2M shares and 4 cut 774K.

SLN top mutual fund and ETF holders

20 largest
Silence Therapeutics plc top fund holders
#Holder% of sharesSharesValueChangeReported
1Fidelity Select Biotechnology3.29%2.0M$17.7M+1.9M (+1,866.0%)August 31, 2026
2MEDICAL BioHealth EUR Acc1.35%837K$7.3M+293,755 (+54.0%)August 31, 2026
3International Biotechnology Ord0.97%604K$5.2M−126,026 (−17.3%)June 30, 2026
4Fidelity Advisor Biotechnology I0.86%532K$4.6M+49,700 (+10.3%)August 31, 2026
5Fidelity Select Health Care0.80%500K$4.3M+500,000 (0.0%)August 31, 2026
6apo Medical Opportunities R0.63%391K$3.4M+145,900 (+59.5%)August 31, 2026
7iShares Biotechnology ETF0.47%290K$2.5M−2,200 (−0.8%)September 30, 2026
8Fidelity Advisor Health Care I0.37%228K$2.0M+228,000 (0.0%)August 31, 2026
9RIM Global Bioscience EUR0.19%116K$1.0M+15,000 (+14.8%)June 30, 2026
10Alger Small Cap Growth A0.17%106K$917,294+105,679 (0.0%)July 31, 2026
11abrdn World Healthcare0.17%105K$911,400+105,000 (0.0%)August 31, 2026
12Fidelity VIP Health Care Initial0.14%85K$737,800+85,000 (0.0%)August 31, 2026
13Alger Small Cap Growth I-20.13%83K$724,016+83,412 (0.0%)July 31, 2026
14Galileo - Biotech Innovation Fund S USD0.09%59K$509,039—March 31, 2026
15Alger Small Cap Growth Institutional I0.07%41K$358,415+41,292 (0.0%)July 31, 2026
16iShares Nasdaq US Biotech ETF USD Acc0.06%40K$348,615+340 (+0.9%)September 30, 2026
17WEALTHGATE Biotech Fund Inst0.06%38K$332,704+38,330 (0.0%)June 30, 2026
18State Street® SPDR® S&P® Intl Sm Cp ETF0.04%22K$189,224—September 30, 2026
19Fidelity Nasdaq Composite Index0.03%16K$138,698−13,559 (−45.9%)August 31, 2026
20ActivePassive International Equity ETF0.02%9,520$82,634—September 30, 2026

Funds report holdings monthly or quarterly; dates differ by fund.

SLN shares outstanding

Shares outstanding

Year-end shares outstanding, adjusted for splits.

Who owns SLN

Institutional investors own 49.3% of Silence Therapeutics's shares and insiders 7.97%. The largest holder is Siren, L.L.C. with 5.33% of the shares (3.3M), as of June 30, 2026. Among the top 20 institutions, 12 added shares and 4 reduced their stake in the latest filings. Short interest is 5.02% of the float, or 3.00 days of average trading volume. The share count fell 9.3% since 2014.

Related: SLN analyst forecast, SLN key metrics. See the SLN stock overview for the latest quote and news.

SLN ownership FAQ

Who owns the most Silence Therapeutics stock?

The largest shareholders of Silence Therapeutics are Siren, L.L.C. (5.33%), TCG Crossover Management, LLC (4.88%), Nantahala Capital Management, LLC (4.33%), Redmile Group, LLC (3.48%), Citadel Advisors Llc (2.14%).

What percentage of Silence Therapeutics is owned by institutions?

Institutions hold 49.3% of Silence Therapeutics's shares outstanding; insiders hold 7.97%.

Which funds own Silence Therapeutics?

The largest fund holders of Silence Therapeutics are Fidelity Select Biotechnology (3.29%), MEDICAL BioHealth EUR Acc (1.35%), International Biotechnology Ord (0.97%), Fidelity Advisor Biotechnology I (0.86%), Fidelity Select Health Care (0.80%).

What is Silence Therapeutics's short interest?

2.5M shares of Silence Therapeutics were sold short, 5.02% of the float; at the average daily volume it would take 3.00 days to cover.

How many shares of Silence Therapeutics are outstanding?

Silence Therapeutics has 62.2M shares outstanding, of which 37.9M are in the public float.

Biotechnology: ownership