Fidelity Disruptive Medicine ETF (FMED) Holdings
FMED holdings summary
as of Oct 24, 2026- Holdings
- 70 positions listed
- Top 10 weight
- 34.4% of net assets
- Effective holdings
- 45 equal-weight equivalent
- Largest holding
- TXG 4.56% 10x Genomics, Inc.
- Annual turnover
- 0.0% of the portfolio traded
All FMED holdings
| # | Name | ||||||
|---|---|---|---|---|---|---|---|
| 1 | TXG | 10x Genomics, Inc. | Healthcare | 4.56% | $2.3M | $9.10B | — |
| 2 | TMO | Thermo Fisher Scientific Inc. | Healthcare | 4.24% | $2.2M | $255.13B | 37.1 |
| 3 | NTRA | Natera, Inc. | Healthcare | 4.20% | $2.2M | $56.71B | — |
| 4 | DHR | Danaher Corporation | Healthcare | 4.14% | $2.1M | $161.01B | 40.8 |
| 5 | ILMN | Illumina, Inc. | Healthcare | 3.62% | $1.9M | $39.64B | 49.0 |
| 6 | LFST | LifeStance Health Group, Inc. | Healthcare | 2.86% | $1.5M | $4.46B | 90.3 |
| 7 | ARGX | argenx SE | Healthcare | 2.84% | $1.5M | $51.51B | 31.2 |
| 8 | DIM | Sartorius Stedim Biotech SA | Healthcare | 2.78% | $1.4M | — | — |
| 9 | RVMD | Revolution Medicines, Inc. | Healthcare | 2.68% | $1.4M | $38.14B | — |
| 10 | WST | West Pharmaceutical Services, Inc. | Healthcare | 2.47% | $1.3M | $27.03B | 49.4 |
| 11 | ISRG | Intuitive Surgical, Inc. | Healthcare | 2.43% | $1.2M | $150.74B | 48.9 |
| 12 | HTFL | Heartflow, Inc. | Healthcare | 2.42% | $1.2M | $4.20B | — |
| 13 | MRNA | Moderna, Inc. | Healthcare | 2.38% | $1.2M | $87.04B | — |
| 14 | ALNY | Alnylam Pharmaceuticals, Inc. | Healthcare | 2.20% | $1.1M | $31.02B | 39.1 |
| 15 | GH | Guardant Health, Inc. | Healthcare | 2.18% | $1.1M | $21.28B | — |
| 16 | COGT | Cogent Biosciences, Inc. | Healthcare | 2.00% | $1.0M | $5.12B | — |
| 17 | UCB | UCB SA | Healthcare | 1.99% | $1.0M | — | — |
| 18 | KNSA | Kiniksa Pharmaceuticals, Ltd. | Healthcare | 1.97% | $1.0M | $6.13B | 79.4 |
| 19 | VEEV | Veeva Systems Inc. | Healthcare | 1.84% | $944,174.47 | $50.25B | 50.9 |
| 20 | KYMR | Kymera Therapeutics, Inc. | Healthcare | 1.79% | $921,285.08 | $8.62B | — |
| 21 | PCVX | Vaxcyte, Inc. | Healthcare | 1.79% | $920,770.71 | $10.01B | — |
| 22 | ASND | Ascendis Pharma A/S | Healthcare | 1.79% | $919,227.61 | $14.82B | 17.3 |
| 23 | RGEN | Repligen Corporation | Healthcare | 1.76% | $906,008.34 | $11.14B | 240.3 |
| 24 | ROIV | Roivant Sciences Ltd. | Healthcare | 1.59% | $819,851.65 | $24.22B | — |
| 25 | UNH | UnitedHealth Group Incorporated | Healthcare | 1.47% | $756,635.78 | $360.32B | 25.8 |
| 26 | EW | Edwards Lifesciences Corporation | Healthcare | 1.45% | $747,531.46 | $49.92B | 51.5 |
| 27 | INSM | Insmed Incorporated | Healthcare | 1.40% | $717,543.79 | $21.02B | — |
| 28 | VRDN | Viridian Therapeutics, Inc. | Healthcare | 1.36% | $697,689.18 | $2.16B | — |
| 29 | TWST | Twist Bioscience Corporation | Healthcare | 1.31% | $673,565.30 | $8.80B | — |
| 30 | WAY | Waystar Holding Corp. | Healthcare | 1.27% | $653,144.88 | $5.25B | 39.1 |
| 31 | KMTS | Kestra Medical Technologies, Ltd. | Healthcare | 1.25% | $642,497.46 | $1.62B | — |
| 32 | AMLX | Amylyx Pharmaceuticals, Inc. | Healthcare | 1.19% | $610,658.06 | $3.31B | — |
| 33 | BTSG | BrightSpring Health Services, Inc. | Healthcare | 1.16% | $595,535.63 | $12.04B | 53.9 |
| 34 | VCYT | Veracyte, Inc. | Healthcare | 1.14% | $587,922.98 | $3.47B | 30.8 |
| 35 | CAI | Caris Life Sciences, Inc. | Healthcare | 1.14% | $586,791.37 | $8.64B | 18.1 |
| 36 | BRKR | Bruker Corporation | Healthcare | 1.11% | $571,668.94 | $8.35B | — |
| 37 | BSX | Boston Scientific Corporation | Healthcare | 1.06% | $545,744.78 | $64.33B | 18.0 |
| 38 | AXSM | Axsome Therapeutics, Inc. | Healthcare | 1.06% | $543,430.12 | $8.23B | — |
| 39 | ELVN | Enliven Therapeutics, Inc. | Healthcare | 1.01% | $517,197.34 | $2.73B | — |
| 40 | LLY | Eli Lilly and Company | Healthcare | 0.99% | $511,590.72 | $1.12T | 42.2 |
| 41 | DFTX | Definium Therapeutics, Inc. | Healthcare | 0.98% | $504,595.31 | $4.31B | — |
| 42 | RLAY | Relay Therapeutics, Inc. | Healthcare | 0.97% | $501,097.61 | $3.57B | — |
| 43 | ORKA | Oruka Therapeutics, Inc. | Healthcare | 0.97% | $496,571.17 | $4.76B | — |
| 44 | IRON | Disc Medicine, Inc. | Healthcare | 0.97% | $496,416.86 | $2.18B | — |
| 45 | LEGN | Legend Biotech Corporation | Healthcare | 0.89% | $455,987.51 | $3.59B | — |
| 46 | IRTC | iRhythm Technologies, Inc. | Healthcare | 0.86% | $442,305.31 | $3.58B | — |
| 47 | PRAX | Praxis Precision Medicines, Inc. | Healthcare | 0.85% | $437,470.25 | $6.75B | — |
| 48 | MBX | MBX Biosciences, Inc. | Healthcare | 0.76% | $392,051.53 | $2.39B | — |
| 49 | STOK | Stoke Therapeutics, Inc. | Healthcare | 0.73% | $375,128.81 | $1.56B | — |
| 50 | ZLAB | Zai Lab Limited | Healthcare | 0.71% | $364,892.88 | $2.60B | — |
| 51 | XENE | Xenon Pharmaceuticals Inc. | Healthcare | 0.67% | $343,032.23 | $3.24B | — |
| 52 | DNTH | Dianthus Therapeutics, Inc. | Healthcare | 0.65% | $336,756.93 | $4.03B | — |
| 53 | KH6_old | KINGHERO | Other | 0.64% | $330,121.58 | — | — |
| 54 | DXCM | DexCom, Inc. | Healthcare | 0.61% | $311,398.57 | $32.47B | 34.1 |
| 55 | TRAX | First Tracks Biotherapeutics | Healthcare | 0.55% | $281,616.65 | $1.23B | — |
| 56 | CTMX | CytomX Therapeutics, Inc. | Healthcare | 0.53% | $272,666.64 | $496.8M | — |
| 57 | ZBIO | Zenas BioPharma, Inc. | Healthcare | 0.52% | $269,528.99 | $1.62B | — |
| 58 | SYRE | Spyre Therapeutics, Inc. | Healthcare | 0.47% | $243,553.39 | $7.47B | — |
| 59 | PHVS | Pharvaris N.V. | Healthcare | 0.45% | $233,728.96 | $1.95B | — |
| 60 | JANX | Janux Therapeutics, Inc. | Healthcare | 0.37% | $189,853.34 | $1.01B | — |
| 61 | ALHC | Alignment Healthcare, Inc. | Healthcare | 0.36% | $183,835.23 | $1.72B | 43.6 |
| 62 | CGON | CG Oncology, Inc. | Healthcare | 0.34% | $172,827.75 | $5.31B | — |
| 63 | SEPN | Septerna, Inc. | Healthcare | 0.33% | $170,976.03 | $1.70B | — |
| 64 | GPCR | Structure Therapeutics Inc. | Healthcare | 0.32% | $162,283.20 | $1.50B | — |
| 65 | ELYM | Eliem Therapeutics Inc | Healthcare | 0.28% | $141,657.03 | — | — |
| 66 | JBIO | Jade Biosciences, Inc. | Healthcare | 0.27% | $140,062.49 | $856.7M | — |
| 67 | OM | Outset Medical, Inc. | Healthcare | 0.27% | $139,702.43 | $74.1M | — |
| 68 | VKTX | Viking Therapeutics, Inc. | Healthcare | 0.26% | $133,684.32 | $3.20B | — |
| 69 | OLMA | Olema Pharmaceuticals, Inc. | Healthcare | 0.18% | $94,695.21 | $575.7M | — |
| 70 | ANNX | Annexon, Inc. | Healthcare | 0.18% | $90,837.44 | $646.5M | — |
Weights as a percentage of net assets. Value held = weight × net assets ($51.4M). Market cap and P/E from each company's latest fundamentals (U.S.-listed stocks).
FMED sector breakdown
Sum of the weights of the holdings in each sector.
FMED top industries
FMED overlap with other ETFs
| ETF | Fund | Overlap | Shared holdings | Expense ratio |
|---|---|---|---|---|
| IWM | iShares Russell 2000 ETF | 4.5% | 37 of 1,962 | 0.19% |
| VTI | Vanguard Total Stock Market ETF | 3.1% | 59 of 2,941 | 0.03% |
| SPY | SPDR S&P 500 ETF | 2.9% | 12 of 502 | 0.09% |
| DIA | SPDR Dow Jones Industrial Average ETF | 1.5% | 1 of 30 | 0.16% |
| QQQ | Invesco QQQ ETF | 1.3% | 4 of 101 | 0.17% |
| VXUS | Vanguard Total International Stock ETF | 0.2% | 5 of 8,035 | 0.05% |
Overlap = sum over shared holdings of the smaller of the two weights. 100% means identical portfolios.
About the FMED portfolio
Fidelity Disruptive Medicine ETF holds 70 positions. The ten largest make up 34.4% of the fund and the top 50 90.6%, so it behaves like a portfolio of about 45 equally weighted stocks. The biggest positions are 10x Genomics, Inc. (4.56%), Thermo Fisher Scientific Inc. (4.24%), Natera, Inc. (4.20%), Danaher Corporation (4.14%), Illumina, Inc. (3.62%).
By sector, Healthcare is 98.2%, Other is 0.6%. Holdings data is from the fund's latest portfolio as reported by EODHD on October 24, 2026; positions change as the fund rebalances.
Related: FMED chart, FMED performance, FMED overview.
FMED holdings FAQ
How many holdings does FMED have?
FMED holds 70 positions as of October 24, 2026.
What are the top 10 holdings of FMED?
The ten largest holdings are 10x Genomics, Inc. (4.56%), Thermo Fisher Scientific Inc. (4.24%), Natera, Inc. (4.20%), Danaher Corporation (4.14%), Illumina, Inc. (3.62%), LifeStance Health Group, Inc. (2.86%), argenx SE (2.84%), Sartorius Stedim Biotech SA (2.78%), Revolution Medicines, Inc. (2.68%), West Pharmaceutical Services, Inc. (2.47%). Together they are 34.4% of the fund.
What percentage of FMED is 10x Genomics, Inc.?
10x Genomics, Inc. is the largest holding at 4.56% of net assets, about $2.3M of the fund's $51.4M.
How concentrated is FMED?
The top 10 holdings are 34.4% of the fund. By the effective number of holdings (1 divided by the sum of squared weights) FMED behaves like a portfolio of about 45 equally weighted stocks.