iShares Neuroscience and Healthcare ETF (IBRN) Performance
IBRN total return
Distributions reinvested · as of Oct 23, 2026- YTD
- −3.0% since Dec 31, 2025
- 1 year
- +9.1% total return
- 3 years
- +17.4% a year
- Since first price
- +6.4% a year since 2022
IBRN trailing returns vs SPY, QQQ, AGG
| Period | IBRN total return | Price only | S&P 500 (SPY) | Nasdaq-100 (QQQ) | U.S. bonds (AGG) |
|---|---|---|---|---|---|
| 1 month | −8.0% | −8.0% | −1.0% | −5.0% | +0.9% |
| 3 months | −17.0% | −17.0% | +3.2% | +1.9% | −0.4% |
| 6 months | −9.5% | −9.5% | +7.8% | +8.4% | −1.5% |
| YTD | −3.0% | −3.0% | +12.3% | +15.1% | −1.0% |
| 1 year | +9.1% | +8.1% | +14.4% | +15.9% | −1.1% |
| 3 years | +61.9%+17.4%/yr | +59.6% | +87.4%+23.3%/yr | +101.4%+26.3%/yr | +16.6%+5.2%/yr |
| Since inceptionAug 26, 2022 | +29.5%+6.4%/yr | +27.7% | — | — | — |
Total return from adjusted closes (distributions reinvested, before tax). Periods of 3 years or more are also shown annualized. Price only excludes distributions.
Growth of $10,000: IBRN vs SPY
From Aug 26, 2022: IBRN grew to $12,949, SPY to $19,830.
Year-end values with distributions reinvested, no taxes or trading costs. Start: first common trading day of both funds.
IBRN returns by calendar year
2 of 3 full years positive. Best 2025 (+28.5%), worst 2024 (−2.8%). 2026 is year to date.
IBRN annual returns table
| Year | IBRN | Largest drop | SPY | QQQ | AGG |
|---|---|---|---|---|---|
| 2026YTD | −3.0% | −26.3% | +12.3% | +15.1% | −1.0% |
| 2025 | +28.5% | −31.2% | +17.7% | +20.8% | +7.2% |
| 2024 | −2.8% | −15.2% | +24.9% | +25.6% | +1.3% |
| 2023 | +0.9% | −30.3% | +26.2% | +54.9% | +5.7% |
Largest drop = deepest fall from a high within that calendar year.
Calendar-year return vs largest drop within the year
Most years include a sizable fall at some point even when the year ends higher.
IBRN largest drawdowns
Now 22.9% below the high| Peak | Decline | Bottom | Recovered | Fall | Underwater |
|---|---|---|---|---|---|
| Nov 11, 2024 | −35.4% | Apr 8, 2025 | Oct 16, 2025 | 5 months | 11 months |
| Feb 2, 2023 | −30.3% | Oct 27, 2023 | Oct 17, 2024 | 9 months | 1.7 years |
| Aug 19, 2026 | −26.3% | Oct 14, 2026 | not yet | 56 days | 2 months so far |
Declines from a closing high (distributions reinvested) of 10% or more. Underwater = time from the peak until the old high was regained.
IBRN risk statistics
| Statistic | 3 years | Since 2022 |
|---|---|---|
| Annualized return | +17.1% | +8.5% |
| Volatility (annualized) | 24.3% | 22.6% |
| Sharpe ratio | 0.59 | 0.28 |
| Sortino ratio | 1.01 | 0.44 |
| Best month | +22.2% | +22.2% |
| Worst month | −14.6% | −14.6% |
| Best 12 months | +79.0% | +79.0% |
| Worst 12 months | −12.3% | −23.4% |
| Positive months | 64% | 61% |
| Beta vs S&P 500 | 0.83 | — |
| Correlation with S&P 500 | 0.43 | — |
From monthly total returns. Sharpe and Sortino use 1–3 month T-bills (BIL) as the risk-free rate, so they need history from 2007 on.
IBRN rolling returns
| Holding period | Periods | Worst | Median | Best | Positive |
|---|---|---|---|---|---|
| 1-year | 39 | −23.4% | +4.1% | +79.0% | 59% |
| 3-year (a year) | 15 | +1.2% | +11.9% | +19.7% | 100% |
Every holding period starting at a month-end since 2022. Returns for 3 years and longer are annualized.
IBRN performance overview
iShares Neuroscience and Healthcare ETF (IBRN) returned +9.1% over the past year, with distributions reinvested. Since its first recorded price in 2022 it has returned +6.4% a year, turning $10,000 into about $12,949. Over the same year S&P 500 (SPY) returned +14.4%.
The deepest decline was −35.4%, from Nov 11, 2024 to Apr 8, 2025, and it took 6 months to get back to the old high. IBRN finished 2 of its 3 full calendar years with a gain; the best year was 2025 (+28.5%) and the worst 2024 (−2.8%). Volatility has been 22.6% a year.
Related: IBRN chart, IBRN holdings, IBRN dividends. See the IBRN overview for the latest quote and fund facts.
IBRN performance FAQ
What is the IBRN return over the past year?
IBRN returned +9.1% over the 12 months to October 23, 2026, including reinvested distributions. On price alone it rose 8.1%.
How much would $10,000 invested in IBRN be worth?
$10,000 invested in IBRN at its first recorded close on August 26, 2022 would be worth about $12,949 on October 23, 2026 with distributions reinvested.
What was the worst year for IBRN?
The worst calendar year was 2024, with a total return of −2.8%. The best was 2025 at +28.5%.
What is the biggest drawdown of IBRN?
The largest peak-to-trough decline was −35.4% between November 11, 2024 and April 8, 2025. It recovered to the old high on October 16, 2025, 6 months after the bottom.
How volatile is IBRN?
Over the past 3 years IBRN had an annualized volatility of 24.3% and a Sharpe ratio of 0.59 (excess return over 1–3 month T-bills per unit of risk).